The Effect of CYP2C19 and CYP2D6 Genotypes on the Metabolism of Clomipramine in Japanese Psychiatric Patients

The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans.

1994 • 958 citations

Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese.

1994 • 749 citations

Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine.

1993 • 652 citations

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1980 • 544 citations

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

1985 • 459 citations

Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation.

1994 • 429 citations

Pronounced differences between native Chinese and Swedish populations in the polymorphic hydroxylations of debrisoquin and S-mephenytoin

1992 • 406 citations

Fluvoxamine is a potent inhibitor of cytochrome P4501A2

1993 • 370 citations

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

1990 • 363 citations

Steady-state plasma levels of nortriptyline in twins: Influence of genetic factors and drug therapy

1969 • 361 citations

Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine

1996 • 314 citations

Ultrarapid hydroxylation of debrisoquine in a Swedish population. Analysis of the molecular genetic basis.

1995 • 310 citations

10-hydroxylation of nortriptyline in white persons with 0, 1, 2, 3, and 13 functional CYP2D6 genes*

1998 • 284 citations

Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology

1995 • 243 citations

The Emerging Role of Cytochrome P450 3A in Psychopharmacology

1995 • 167 citations

Plasma levels of chlorimipramine and its demethyl metabolite during treatment of depression

1979 • 142 citations

Polymorphic Drug Oxidation

1996 • 141 citations

Analysis of the gene in relation to dextromethorphan -demethylation capacity in a Japanese population

1999 • 117 citations

Genetic analysis of the CYP2D locus in relation to debrisoquine hydroxylation capacity in Korean, Japanese and Chinese subjects

1995 • 96 citations

Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine

1991 • 95 citations

Single-dose kinetics of clomipramine: Relationship to the sparteine and S-mephenytoin oxidation polymorphisms

1994 • 92 citations

The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways.

1996 • 86 citations

Fluvoxamine and fluoxetine: interaction studies with amitriptyline, clomipramine and neuroleptics in phenotyped patients

1995 • 75 citations

Inhibition of antidepressant demethylation and hydroxylation by fluvoxamine in depressed patients

1993 • 75 citations

LIVING AND DYING IN THE NINETEENTH CENTURY.

1963 • 69 citations

Effects of the CYP2D6 genotype on the steady-state plasma concentrations of haloperidol and reduced haloperidol in Japanese schizophrenic patients

1997 • 69 citations

Dissociation of co-regulatory control of debrisoquin/phenformin and sparteine oxidation in Ghanaians

1985 • 63 citations

Steady-State Plasma Levels of Nortriptyline and Its Hydroxylated Metabolites in Japanese Patients: Impact of CYP2D6 Genotype on the Hydroxylation of Nortriptyline

2000 • 60 citations

Reversed-phase liquid chromatography for the separation of chlorpromazine, imipramine and some of their metabolites

1981 • 59 citations

Evidence for polymorphic oxidation of sparteine in Japanese subjects.

1987 • 55 citations

Steady-state plasma levels of clomipramine and its metabolites: Impact of the sparteine/debrisoquine oxidation polymorphism

1992 • 51 citations

Clomipramine dose-effect study in patients with depression: Clinical end points and pharmacokinetics

1999 • 38 citations

Metabolism of Desipramine in Japanese Psychiatric Patients: The Impact of CYP2D6 Genotype on the Hydroxylation of Desipramine

2000 • 28 citations

Phenobarbital Induces the 2-Hydroxylation of Desipramine

1996 • 28 citations

Pronounced Differences in the Disposition of Clomipramine Between Japanese and Swedish Patients

1999 • 28 citations

The effect of neuroleptics on imipramine demethylation in rat liver microsomes and imipramine and desipramine level in the rat brain

1986 • 24 citations

Non-competitive inhibition of clomipramineN-demethylation by fluvoxamine

1995 • 21 citations

Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data

1993 • 21 citations

No Interaction of Diazepam on Amitriptyline Disposition in Depressed Patients

1987 • 17 citations

Alprazolam Does Not Inhibit the Metabolism of Nortriptyline in Depressed Patients of Inhibit the Metabolism of Desipramine in Human Liver Microsomes

1988 • 14 citations

Increases in Plasma Concentration of m-Chlorophenylpiperazine, but not Trazodone, with Low-Dose Haloperidol

1997 • 13 citations

Interindividual Variations of Desmethylation and Hydroxylation of Clomipramine in an Oriental Psychiatric Population

1993 • 12 citations

Interindividual variations of desmethylation and hydroxylation of clomipramine in an Oriental psychiatric population.

1993 • 12 citations

Influence of neuroleptics on the metabolism of tricyclic antidepressants—in vitro experiments with rat liver microsomes

1986 • 11 citations

Effects of various factors including the CYP2D6 genotype and coadministration of flunitrazepam on the steady-state plasma concentrations of bromperidol and its reduced metabolite

1998 • 10 citations