Interindividual Variations of Desmethylation and Hydroxylation of Amitriptyline in a Japanese Psychiatric Population

Interethnic differences in genetic polymorphism of debrisoquin and mephenytoin hydroxylation between Japanese and Caucasian populations

1985 • 459 citations

Steady-state plasma levels of nortriptyline in twins: Influence of genetic factors and drug therapy

1969 • 361 citations

Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds

1967 • 266 citations

E- and Z-10-hydroxylation of nortriptyline: Relationship to polymorphic debrisoquine hydroxylation

1981 • 171 citations

Plasma levels of chlorimipramine and its demethyl metabolite during treatment of depression

1979 • 142 citations

The mephenytoin oxidation polymorphism is partially responsible for the N-demethylation of imipramine

1991 • 139 citations

Genetic polymorphism of mephenytoin p(4′)‐hydroxylation: difference between Orientals and Caucasians.

1985 • 111 citations

Pronounced inhibition of noradrenaline uptake by 10-hydroxymetabolites of nortriptyline

1979 • 106 citations

Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism

1986 • 98 citations

The debrisoquine hydroxylation test predicts steady‐state plasma levels of desipramine.

1983 • 93 citations

Active metabolites of imipramine and desipramine in man

1982 • 89 citations

Urinary excretion of nortriptyline and five of its metabolites in man after single and multiple oral doses

1973 • 88 citations

Genetically determined polymorphisms in drug oxidation

1986 • 88 citations

Amitriptyline metabolism: Association with debrisoquin hydroxylation in nonsmokers

1986 • 82 citations

Phenotypic consistency in hydroxylation of desmethylimipramine and debrisoquine in healthy subjects and in human liver microsomes

1984 • 82 citations

Importance of oxidative polymorphism and levomepromazine treatment on the steady-state blood concentrations of clomipramine and its major metabolites

1986 • 77 citations

Steady-state levels of imipramine and its metabolites: Significance of dose-dependent kinetics

1986 • 77 citations

Amitriptyline metabolism: Relationship to polymorphic debrisoquine hydroxylation

1983 • 70 citations

Plasma concentrations of nortriptyline and its 10‐hydroxy metabolite in depressed patients‐relationship to the debrisoquine hydroxylation metabolic ratio.

1985 • 69 citations

Steady-state kinetics of imipramine in patients

1977 • 64 citations

Role of oxidation polymorphism on blood and urine concentrations of amitriptyline and its metabolites in man

1982 • 61 citations

Evidence for polymorphic oxidation of sparteine in Japanese subjects.

1987 • 55 citations

Interindividual differences in amitriptyline demethylation

1980 • 55 citations

Hydroxylation of desmethylimipramine: Dependence on the debrisoquin hydroxylation phenotype

1987 • 50 citations

Desipramine hydroxylation: Variability and effect of antipsychotic drugs

1983 • 50 citations

Stereospecific hydroxylation of nortriptyline in man in relation to interindividual differences in its steady-state plasma level

1972 • 49 citations

Antidepressive effect and pharmacokinetics of amitriptyline with consideration of unbound drug and 10-hydroxynortriptyline plasma levels

1982 • 45 citations

Steady-state plasma concentrations of cis- and trans-10-OH amitriptyline metabolites

1982 • 39 citations

Demethylation and hydroxylation of amitriptyline, nortriptyline, and 10-hydroxyamitriptyline in human liver microsomes.

1981 • 39 citations

Relationship between the plasma concentration of clomipramine and desmethylclomipramine in depressive patients and the clinical response

1982 • 35 citations

Nortriptyline and 10-hydroxynortriptyline plasma concentrations

1976 • 28 citations

Nortriptyline and debrisoquine hydroxylations in Ghanaian and Swedish subjects

1984 • 26 citations

The effect of neuroleptics on imipramine demethylation in rat liver microsomes and imipramine and desipramine level in the rat brain

1986 • 24 citations

Amitriptyline and Hydroxylated Metabolite Plasma Levels in Depressed Outpatients

1985 • 21 citations

Intraindividual Similarity in the Metabolism of Amitriptyline and Chlorimipramine in Depressed Patients

1979 • 18 citations

No Interaction of Diazepam on Amitriptyline Disposition in Depressed Patients

1987 • 17 citations

Alprazolam Does Not Inhibit the Metabolism of Nortriptyline in Depressed Patients of Inhibit the Metabolism of Desipramine in Human Liver Microsomes

1988 • 14 citations

Interindividual Variations of Desmethylation and Hydroxylation of Clomipramine in an Oriental Psychiatric Population

1993 • 12 citations

Interindividual variations of desmethylation and hydroxylation of clomipramine in an Oriental psychiatric population.

1993 • 12 citations

Influence of neuroleptics on the metabolism of tricyclic antidepressants—in vitro experiments with rat liver microsomes

1986 • 11 citations