Serotonergic Drugs

Differential expression of orexin receptors 1 and 2 in the rat brain

2001 • 1,593 citations

Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

2005 • 1,509 citations

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

1995 • 1,264 citations

Appetite-Suppressant Drugs and the Risk of Primary Pulmonary Hypertension

1996 • 1,131 citations

Distribution of orexin neurons in the adult rat brain

1999 • 1,052 citations

Effect of sibutramine on weight maintenance after weight loss: a randomised trial

2000 • 833 citations

Appetite-suppressant drugs and the risk of primary pulmonary hypertension

1997 • 582 citations

SB 242084, a Selective and Brain Penetrant 5-HT 2C Receptor Antagonist

1997 • 519 citations

Activation of Central Melanocortin Pathways by Fenfluramine

2002 • 481 citations

Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord

2001 • 457 citations

Serotonergic control of the organization of feeding and satiety

1995 • 419 citations

5-HT Receptor Classification and Nomenclature: Towards a Harmonization with the Human Genome

1997 • 413 citations

Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake

2006 • 399 citations

Is there a role for serotonin (5-hydroxytryptamine) in feeding?

1977 • 345 citations

Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials

2003 • 342 citations

Convergent Excitation of Dorsal Raphe Serotonin Neurons by Multiple Arousal Systems (Orexin/Hypocretin, Histamine and Noradrenaline)

2002 • 339 citations

INTERNATIONAL TRIAL OF LONG-TERM DEXFENFLURAMINE IN OBESITY

1989 • 315 citations

Evidence that mCPP may have behavioural effects mediated by central 5‐HT_1C receptors

1988 • 299 citations

5-ht6 Receptors

2004 • 296 citations

Pharmacotherapy for obesity: a quantitative analysis of four decades of published randomized clinical trials

2002 • 292 citations

Reduced satiating effect of d -fenfluramine in serotonin 5-HT 2C receptor mutant mice

1999 • 290 citations

Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat

2001 • 267 citations

Evidence that hypophagia induced bymCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors

1988 • 257 citations

The Efficacy and Safety of Sibutramine for Weight Loss

2004 • 253 citations

Efficacy and Safety of Sibutramine in Obese White and African American Patients With Hypertension

2000 • 249 citations

Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.

1983 • 240 citations

Current and Investigational Antiobesity Agents and Obesity Therapeutic Treatment Targets

2004 • 228 citations

Behavioral Satiety Sequence (BSS) for the Diagnosis of Drug Action on Food Intake

1998 • 226 citations

Fenfluramine

1975 • 210 citations

Evidence that hypophagia induced by d-fenfluramine and d-norfenfluramine in the rat is mediated by 5-HT2C receptors

2001 • 199 citations

Serotonergic Regulation of the Orexin/Hypocretin Neurons through the 5-HT_1AReceptor

2004 • 190 citations

Central Serotonin and Melanocortin Pathways Regulating Energy Homeostasis

2003 • 186 citations

Thermogenic effects of sibutramine in humans

1998 • 184 citations

Separate systems for serotonin and leptin in appetite control

2000 • 179 citations

A Randomized Trial of Sibutramine in the Management of Obese Type 2 Diabetic Patients Treated With Metformin

2003 • 170 citations

Carbohydrate craving in obese people: Suppression by treatments affecting serotoninergic transmission

1981 • 169 citations

Fluoxetine: a randomized clinical trial in the treatment of obesity.

1994 • 162 citations

Original Articles Sibutramine Reduces Food Intake in Non‐Dieting Women with Obesity

1998 • 161 citations

The effect of sibutramine on energy expenditure and appetite during chronic treatment without dietary restriction

1999 • 154 citations

5-HT 2C receptor activation decreases appetite and body weight in obese subjects

1997 • 152 citations

Randomized placebo-controlled trial of long-term treatment with sibutramine in mild to moderate obesity.

2001 • 152 citations

Potencies of antagonists indicate that 5‐HT_1C receptors mediate 1–3(chlorophenyl)piperazine‐induced hypophagia

1991 • 150 citations

Effect of anorexic drugs on food intake and the micro-structure of eating in human subjects

1979 • 148 citations

Similarities in the action of Ro 60-0175, a 5-HT2C receptor agonist, and d-fenfluramine on feeding patterns in the rat

2000 • 145 citations

Ritanserin attenuates anorectic, endocrine and thermic responses tod-fenfluramine in human volunteers

1993 • 144 citations

Serotonin 2C receptor agonists and the behavioural satiety sequence in mice

2002 • 132 citations

D-Fenfluramine selectively suppresses carbohydrate snacking by obese subjects

1985 • 127 citations

Characterisation of adjustments to the structure of feeding behaviour following pharmacological treatment: Effects of amphetamine and fenfluramine and the antagonism produced by pimozide and methergoline

1980 • 122 citations

Hyperactivity and Reduced Energy Cost of Physical Activity in Serotonin 5-HT2C Receptor Mutant Mice

2003 • 119 citations

Evidence that d-fenfluramine anorexia is mediated by 5-HT1 receptors

1989 • 116 citations

Fluoxetine's effect on weight loss in obese subjects

1991 • 115 citations

Behavioral mechanisms for the anorectic action of the serotonin (5-HT) uptake inhibitor sertraline in rats: Comparison with directly acting 5-HT agonists

1990 • 111 citations

Studies on food intake of genetically obese rats

1972 • 109 citations

An examination of the behavioural specificity of hypophagia induced by 5-HT1B, 5-HT1C and 5-HT2 receptor agonists using the post-prandial satiety sequence in rats

1994 • 108 citations

Male and female 5-HT1B receptor knockout mice have higher body weights than wildtypes

2001 • 105 citations

Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan

1992 • 101 citations

Evidence for a difference in mechanism of action between fenfluramine- and amphetamine-induced anorexia

1973 • 96 citations

Relationships of Psychiatric Disorders with Overweight and Obesity in an Adult General Population^**

2005 • 93 citations

CP-94,253: a selective serotonin 1B (5-HT 1B ) agonist that promotes satiety

1997 • 92 citations

The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence

1996 • 90 citations

A behavioural profile of fluoxetine-induced anorexia

1989 • 86 citations

m-Chlorophenylpiperazine decreases food intake in a test meal

1994 • 83 citations

Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity

2005 • 82 citations

Oral administration of the 5-HT2C receptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia

2003 • 81 citations

Obesity drugs in clinical development.

2006 • 80 citations

Comparative effects of continuous infusion of mCPP, Ro 60‐0175 and d‐fenfluramine on food intake, water intake, body weight and locomotor activity in rats

2000 • 79 citations

Suppression of food intake in rats by fluoxetine: Comparison of enantiomers and effects of serotonin antagonists

1988 • 78 citations

Reduction of feeding behavior by the serotonin uptake inhibitor sertraline

1988 • 78 citations

Clinical studies with fluoxetine in obesity

1992 • 77 citations

The effect of the 5-HT re-uptake inhibitor fluoxetine on food intake and body weight in healthy male subjects.

1990 • 77 citations

Serotonin and Appetite Regulation

1998 • 76 citations

5-HT1A receptor immunoreactivity in hypothalamic neurons involved in body weight control

2002 • 75 citations

5-HT 1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin 1B agonist CP-94,253

2002 • 73 citations

Moderate dieting causes 5-HT _2C receptor supersensitivity

1996 • 72 citations

Acute fenfluramine administration reduces neuropeptide Y concentrations in specific hypothalamic regions of the rat: Possible implications for the anorectic effect of fenfluramine

1991 • 69 citations

Twenty-four–hour plasma tryptophan concentrations and ratios are below normal in obese subjects and are not normalized by substantial weight reduction

2003 • 68 citations

Efficacy and Safety of Long‐Term Fluoxetine Treatment of Obesity ‐ Maximizing Success

1995 • 67 citations

Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients

1998 • 66 citations

Serotoninergic Manipulation, Meal‐Induced Satiety and Eating Pattern: Effect of Fluoxetine in Obese Female Subjects

1995 • 63 citations

Dopamine and serotonin VMN release is related to feeding status in obese and lean Zucker rats

2000 • 63 citations

Sertraline and Relapse Prevention Training Following Treatment by Very‐Low‐Calorie Diet: A Controlled Clinical Trial

1995 • 63 citations

Serotonin receptor ligands and the treatment of obesity.

2004 • 62 citations

Sensitivity of the appetite control system in obese subjects to nutritional and serotoninergic challenges.

1990 • 61 citations

Effect of serotonin re-uptake inhibition by fluoxetine on body weight and spontaneous food choice in obesity.

1991 • 56 citations

Parabrachial infusion of d-fenfluramine reduces food intake

2002 • 51 citations

Evidence that central 5-HT2 receptors do not play an important role in the anorectic activity of d-fenfluramine in the rat

1989 • 51 citations

Short-term effects of sibutramine (ReductilTM) on appetite and eating behaviour and the long-term therapeutic outcome

2003 • 51 citations

Weight loss in obese Mexican Americans treated for 1-year with orlistat and lifestyle modification

2003 • 51 citations

Sumatriptan decreases food intake and increases plasma growth hormone in healthy women

1997 • 49 citations

Interleukin-1α Injection Into Ventromedial Hypothalamic Nucleus of Normal Rats Depresses Food Intake and Increases Release of Dopamine and Serotonin

1999 • 48 citations

Modalities of the food intake-reducing effect of sibutramine in humans

2000 • 48 citations

Dysregulation of hypothalamic serotonin turnover in diet-induced obese rats

2002 • 46 citations

Sertraline, a serotonin-uptake inhibitor, reduces food intake and body weight in lean rats and genetically obese mice

1992 • 45 citations

Indoline derivatives as 5-HT 2C receptor agonists

2004 • 45 citations

Inhibition of drug-induced anorexia in rats by methysergide

1975 • 45 citations

Involvement of the serotonergic system in orexin-induced behavioral alterations in rats

2002 • 45 citations

Antiobesity effect of YM348, a novel 5-HT2C receptor agonist, in Zucker rats

2004 • 45 citations

Antagonism by methysergide of the 5-hydroxytryptamine-like action of toxic doses of fenfluramine in dogs

1970 • 43 citations

Metergoline antagonizes fluoxetine-induced suppression of food intake but not changes in the behavioural satiety sequence

1996 • 43 citations

Cytokines, tryptophan and anorexia in cancer patients before and after surgical tumor ablation.

1994 • 42 citations

Anti-obesity drug development

2002 • 42 citations

Fluoxetine-Maintained Obese Humans

1999 • 41 citations

Orexins and feeding: special occasions or everyday occurrence?

2002 • 40 citations

Effect of zimelidine, a new antidepressant, on appetite and body weight.

1981 • 38 citations

Hypophagic, endocrine and subjective responses to m‐chlorophenylpiperazine in healthy men and women

1995 • 38 citations

Clinical Pharmacotherapy for Obesity: Current Drugs and Those in Advanced Development

2004 • 38 citations

On the mechanism of action of dexfenfluramine: effect on alliesthesia and appetite motivation in lean and obese subjects.

1988 • 37 citations

Role of serotonin and catecholamines in brain in the feeding suppressant effect of fluoxetine

1992 • 37 citations

Partial reversal of fluoxetine anorexia by the 5-HT antagonist metergoline

1992 • 36 citations

Fluoxetine: A serotonergic appetite suppressant drug

1989 • 36 citations

Effect of fenfluramine on food intake, mood, and performance of humans living in a residential laboratory

1996 • 35 citations

Effects of cocaine- and amphetamine-regulated transcript peptide, leptin and orexins on hypothalamic serotonin release

2001 • 35 citations

Reduction of food consumption and body weight of normal and obese mice by chronic treatment with fluoxetine: A serotonin reuptake inhibitor

1987 • 34 citations

An investigation of the mechanism responsible for fluoxetine-induced hypophagia in rats

1996 • 32 citations

Individual severity of dietary obesity in unselected Wistar rats: relationship with hyperphagia

2000 • 32 citations

Differential effect of d-fenfluramine and metergoline on food intake in human subjects

1988 • 30 citations

Effects of serotonin1/2 receptor agonists on dark-phase food and water intake in rats

2000 • 30 citations

Effect of Nutritional Status and Ozone Exposure on Rat Brain Serotonin

2002 • 28 citations

The Effects of Dieting on Plasma Tryptophan Concentration and Food Intake in Healthy Women

1997 • 27 citations

Integration of hypothalamic feeding and metabolic signals: focus on neuropeptide Y

2003 • 27 citations

Clinical studies with d-fenfluramine

1992 • 27 citations

d-Fenfluramine in a rat model of dietary fat-induced obesity

1993 • 26 citations

Opposite changes in striatal neuropeptide Y immunoreactivity after partial and complete serotonergic depletion in the rat

1996 • 26 citations

Central Serotonergic Effects of m-Chlorophenylpiperazine (mCPP) among Normal Control Adolescents

2003 • 25 citations

Hyperphagia following intraventricular p-chlorophenylalanine-, leucine- or tryptophan-methyl esters: Lack of correlation with whole brain serotonin levels

1979 • 23 citations

The clinical pharmacology of appetite suppressant drugs.

1984 • 23 citations

Drug therapy after very-low-calorie diets

1992 • 23 citations

Experimental Studies on Changes of Neuroendocrine Functions during Starvation and Refeeding

1991 • 22 citations

The effects of the selective serotonin reuptake-inhibitor fluvoxamine on body weight in Zucker rats are mediated by corticotropin-releasing hormone

2001 • 21 citations

Effects of the 5-HT uptake inhibitors, femoxetine and paroxetine, and a 5-HT1A/B agonist, eltoprazine, on the behavioural satiety sequence

1992 • 20 citations

Cancer anorexia: new pathogenic andtherapeutic insights

1996 • 20 citations

Ineffectiveness of hypothalamic serotonin to block neuropeptide Y-induced feeding

1995 • 19 citations

The effect of dexfenfluramine on eating habits in a Dutch ambulatory android overweight population with an overconsumption of snacks.

1995 • 18 citations

Studies on the role of 5-HT receptors in satiation and the effect of d-fenfluramine in the runway test

1990 • 18 citations

Chronic paroxetine infusion influences macronutrient selection in male Sprague–Dawley rats

2003 • 15 citations

Potential Strategies for Ameliorating Early Cancer Anorexia

1999 • 15 citations

Changes in responsiveness to serotonin on rat ventromedial hypothalamic neurons after food deprivation

1996 • 14 citations

Levels of Hypothalamic Neurotransmitters in Lean and Obese Zucker Rats

2002 • 14 citations

Time‐dependent effects of theophylline on myocardial reactive hyperaemias in the anaesthetized dog

1990 • 12 citations