Serotonin and Appetite Regulation

Valvular Heart Disease Associated with Fenfluramine–Phentermine

1997 • 1,595 citations

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

1979 • 1,321 citations

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

1995 • 1,264 citations

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

1986 • 1,255 citations

Appetite-Suppressant Drugs and the Risk of Primary Pulmonary Hypertension

1996 • 1,131 citations

TWO KINDS OF TRYPTAMINE RECEPTOR

1957 • 838 citations

Binge eating disorder: A multisite field trial of the diagnostic criteria

1992 • 781 citations

Eating patterns and obesity

1959 • 621 citations

Cholecystokinin elicits the complete behavioral sequence of satiety in rats.

1975 • 603 citations

Appetite-suppressant drugs and the risk of primary pulmonary hypertension

1997 • 582 citations

A proposed new nomenclature for 5-HT receptors

1993 • 551 citations

Serotonergic control of the organization of feeding and satiety

1995 • 419 citations

Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites

1986 • 386 citations

Fat and carbohydrate overfeeding in humans: different effects on energy storage

1995 • 346 citations

Is there a role for serotonin (5-hydroxytryptamine) in feeding?

1977 • 345 citations

Ethology and psychopharmacology

1995 • 316 citations

Food preferences in human obesity: Carbohydrates versus fats

1992 • 301 citations

Evidence that mCPP may have behavioural effects mediated by central 5‐HT_1C receptors

1988 • 299 citations

The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons

1989 • 288 citations

Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.

1993 • 281 citations

Energy Density and its Role in the Control of Food Intake: Evidence from Metabolic and Community Studies

1996 • 277 citations

Effector Coupling Mechanisms of the Cloned 5-HT1A Receptor

1989 • 273 citations

Evidence that hypophagia induced bymCPP and TFMPP requires 5-HT1C and 5-HT1B receptors; hypophagia induced by RU 24969 only requires 5-HT1B receptors

1988 • 257 citations

Toward a unified theory of serotonin dysregulation in eating and related disorders

1995 • 250 citations

Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.

1983 • 240 citations

The role of dietary fat in obesity.

1997 • 237 citations

Brain serotonin and eating behavior

1986 • 230 citations

Fenfluramine

1975 • 210 citations

A Double‐Blind Randomized Placebo‐Controlled Trial of Sibutramine

1996 • 194 citations

In vivo properties of SB 200646A, a 5‐HT_2C/2B receptor antagonist

1994 • 182 citations

5-HT1B agonists induce anorexia at a postsynaptic site

1987 • 176 citations

Fatal Pulmonary Hypertension Associated with Short-Term Use of Fenfluramine and Phentermine

1997 • 172 citations

Characterization of the human 5-hydroxytryptamine1B receptor.

1992 • 172 citations

Carbohydrate craving in obese people: Suppression by treatments affecting serotoninergic transmission

1981 • 169 citations

Dieting reduces plasma tryptophan and alters brain 5-HT function in women

1990 • 164 citations

3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1*) agonist and rotationally restricted phenolic analog of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole

1990 • 162 citations

Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability

1997 • 162 citations

Investigation of the mechanisms underlying the hypophagic effects of the 5‐HT and noradrenaline reuptake inhibitor, sibutramine, in the rat

1997 • 162 citations

Original Articles Sibutramine Reduces Food Intake in Non‐Dieting Women with Obesity

1998 • 161 citations

Serotonin and Appetite

1990 • 160 citations

Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype.

1992 • 153 citations

5-HT 2C receptor activation decreases appetite and body weight in obese subjects

1997 • 152 citations

Classification and nomenclature of 5-HT receptors: a comment on current issues

1995 • 150 citations

Effect of anorexic drugs on food intake and the micro-structure of eating in human subjects

1979 • 148 citations

Ritanserin attenuates anorectic, endocrine and thermic responses tod-fenfluramine in human volunteers

1993 • 144 citations

Techniques for the experimental measurement of human eating behaviour and food intake: a practical guide.

1995 • 140 citations

A 5-HT receptor in the central nervous system, positively coupled with adenylate cyclase, is antagonized by ICS 205 930

1988 • 137 citations

Sibutramine in weight control: A dose-ranging, efficacy study

1991 • 128 citations

D-Fenfluramine selectively suppresses carbohydrate snacking by obese subjects

1985 • 127 citations

Serotonin, Eating Behavior, and Fat Intake

1995 • 125 citations

Characterisation of adjustments to the structure of feeding behaviour following pharmacological treatment: Effects of amphetamine and fenfluramine and the antagonism produced by pimozide and methergoline

1980 • 122 citations

Animal models of obesity: classification and characterization.

1984 • 122 citations

Anorectic agents : mechanisms of action and tolerance

1981 • 121 citations

The serotonergic agent fluoxetine reduces neuropeptide y levels and neuropeptide y secretion in the hypothalamus of lean and obese rats

1996 • 119 citations

The effect of protein or carbohydrate breakfasts on subsequent plasma amino acid levels, satiety and nutrient selection in normal males

1989 • 117 citations

Evidence that d-fenfluramine anorexia is mediated by 5-HT1 receptors

1989 • 116 citations

Meal patterns and food selection during the development of obesity in rats fed a cafeteria diet

1984 • 116 citations

Energy intake of rats fed a cafeteria diet

1989 • 111 citations

Neuroendocrine Responses to m-Chlorophenylpiperazine and i-Tryptophan in Bulimia

1992 • 111 citations

Behavioral mechanisms for the anorectic action of the serotonin (5-HT) uptake inhibitor sertraline in rats: Comparison with directly acting 5-HT agonists

1990 • 111 citations

Biochemical and behavioral studies of the 5‐HT_1B receptor agonist, CP‐94,253

1992 • 110 citations

Studies on food intake of genetically obese rats

1972 • 109 citations

Isolation of a mouse “5HT1E-like” serotonin receptor expressed predominantly in hippocampus.

1992 • 108 citations

An examination of the behavioural specificity of hypophagia induced by 5-HT1B, 5-HT1C and 5-HT2 receptor agonists using the post-prandial satiety sequence in rats

1994 • 108 citations

Multiple Serotonin Receptors: Opportunities for New Treatments for Obesity?

1995 • 107 citations

High and low fat consumers, their macronutrient intake and body mass index: further analysis of the National Diet and Nutrition Survey of British Adults.

1996 • 106 citations

Infusion of the 5-hydroxytryptamine agonists RU24969 and TFMPP into the paraventricular nucleus of the hypothalamus causes hypophagia

1988 • 102 citations

Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan

1992 • 101 citations

Dieting changes serotonergic function in women, not men: implications for the aetiology of anorexia nervosa?

1987 • 100 citations

Evidence for a difference in mechanism of action between fenfluramine- and amphetamine-induced anorexia

1973 • 96 citations

Central Mechanisms of Anorectic Drugs

1981 • 90 citations

The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence

1996 • 90 citations

m-Chlorophenylpiperazine decreases food intake in a test meal

1994 • 83 citations

The importance of 5-hydroxytryptamine receptors in the gut

1994 • 79 citations

Suppression of food intake in rats by fluoxetine: Comparison of enantiomers and effects of serotonin antagonists

1988 • 78 citations

Reduction of feeding behavior by the serotonin uptake inhibitor sertraline

1988 • 78 citations

The effect of the 5-HT re-uptake inhibitor fluoxetine on food intake and body weight in healthy male subjects.

1990 • 77 citations

Evidence for the effect of tryptophan on the pattern of food consumption in free feeding and food deprived rats

1979 • 75 citations

Behavioural structure and mechanisms of anorexia: Calibration of natural and abnormal inhibition of eating

1985 • 74 citations

Is migraine related to the eating disorders?

1993 • 73 citations

Moderate dieting causes 5-HT _2C receptor supersensitivity

1996 • 72 citations

Serotonergic influences on food intake: Effect of 5-hydroxytryptophan on parameters of feeding behaviour in deprived and free-feeding rats

1979 • 72 citations

Effects of the Diet on Brain Neurotransmitters

2009 • 68 citations

A comparison of the effects of sibutramine hydrochloride, bupropion and methamphetamine on dopaminergic function: evidence that dopamine is not a pharmacological target for sibutramine

1992 • 63 citations

Serotoninergic Manipulation, Meal‐Induced Satiety and Eating Pattern: Effect of Fluoxetine in Obese Female Subjects

1995 • 63 citations

Sertraline and Relapse Prevention Training Following Treatment by Very‐Low‐Calorie Diet: A Controlled Clinical Trial

1995 • 63 citations

Sensitivity of the appetite control system in obese subjects to nutritional and serotoninergic challenges.

1990 • 61 citations

The serotonin (5-HT) antagonist methysergide increases neuropeptide Y (NPY) synthesis and secretion in the hypothalamus of the rat

1995 • 55 citations

Nutrition, serotonin and appetite: Case study in the evolution of a scientific idea

1987 • 53 citations

Cholecystokinin-induced satiety depends on activation of 5-HT1C receptors

1993 • 53 citations

Increased feeding and neuropeptide Y (NPY) but not NPY mRNA levels in the hypothalamus of the rat following central administration of the serotonin synthesis inhibitorp-chlorophenylalanine

1996 • 51 citations

MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype

1989 • 51 citations

Evidence that central 5-HT2 receptors do not play an important role in the anorectic activity of d-fenfluramine in the rat

1989 • 51 citations

Sumatriptan decreases food intake and increases plasma growth hormone in healthy women

1997 • 49 citations

Effects of chronically administered fluoxetine and fenfluramine on food intake, body weight and the behavioural satiety sequence

1992 • 49 citations

In vitro and in vivo effects of d-fenfluramine: no apparent relation between 5-hydroxytryptamine release and hypophagia.

1995 • 47 citations

Serotonin and dietary fat intake: Effects of dexfenfluramine

1995 • 47 citations

Food intake and selection pattern of rats treated with dexfenfluramine, fluoxetine and RU 24969

1990 • 46 citations

Inhibition of drug-induced anorexia in rats by methysergide

1975 • 45 citations

The 5-HT2 Receptor Agonist MK-212 Reduces Food Intake and Increases Resting but Prevents the Behavioural Satiety Sequence

1997 • 45 citations

Antagonism by methysergide of the 5-hydroxytryptamine-like action of toxic doses of fenfluramine in dogs

1970 • 43 citations

Metergoline antagonizes fluoxetine-induced suppression of food intake but not changes in the behavioural satiety sequence

1996 • 43 citations

Injecting 5-HT into the PVN does not prevent feeding induced by injecting 8-OH-DPAT into the raphe

1993 • 43 citations

The 5-HT1B receptor mediates the effect of d-fenfluramine on eating caused by intra-hypothalamic injection of neuropeptide Y

1995 • 43 citations

Plasma concentrations of tryptophan and dieting.

1990 • 40 citations

Evidence for diminished brain 5-hydroxytryptamine biosynthesis in obese diabetic and non-diabetic humans

1985 • 40 citations

CCK antagonists and CCK-monoamine interactions in the control of satiety

1992 • 40 citations

Do serotoninergic drugs decrease energy intake by reducing fat or carbohydrate intake? Effect of d-fenfluramine with supplemented weight-increasing diets

1988 • 39 citations

Effects of dexfenfluramine treatment on body weight and postprandial thermogenesis in obese subjects. A double-blind placebo-controlled study.

1993 • 39 citations

Peripherally administered 5-hydroxytryptamine elicits the full behavioural sequence of satiety

1991 • 38 citations

Peripheral serotonin administration selectively reduces fat intake in rats

1988 • 38 citations

ChemInform Abstract: 3‐(1,2,5,6‐Tetrahydropyrid‐4‐yl)pyrrolo(3,2‐b)pyrid‐5‐one: A Potent and Selective Serotonin (5‐HT1B) Agonist and Rotationally Restricted Phenolic Analogue of 5‐Methoxy‐3‐(1,2,5,6‐tetrahydropyrid‐4‐yl)indole.

1991 • 38 citations

Role of serotonin and catecholamines in brain in the feeding suppressant effect of fluoxetine

1992 • 37 citations

On the mechanism of action of dexfenfluramine: effect on alliesthesia and appetite motivation in lean and obese subjects.

1988 • 37 citations

The 5-HT1A agonist 8-OH-DPAT attenuates the satiating action of cholecystokinin

1992 • 37 citations

Lack of Cross-Tolerance for Hypophagia Induced by DOI versus m-CPP Suggests Separate Mediation by 5-HT2A and 5-HT2C Receptors, Respectively

1995 • 37 citations

Partial reversal of fluoxetine anorexia by the 5-HT antagonist metergoline

1992 • 36 citations

Metergoline potentiates natural feeding and antagonizes the anorectic action of medial hypothalamic 5-hydroxytryptamine

1996 • 36 citations

Behavioural analysis of the anorectic effects of fluoxetine and fenfluramine

1990 • 34 citations

A 5‐HYDROXYTRYPTAMINE‐LIKE MODE OF ANORECTIC ACTION FOR 6‐CHLORO‐2‐[1‐PIPERAZINYL]‐PYRAZINE (MK‐212)

1978 • 34 citations

Fenfluramine disrupts the behavioural satiety sequence in rats

1988 • 33 citations

Reciprocal interaction of 5‐hydroxytryptamine and cholecystokinin in the control of feeding patterns in rats

1993 • 31 citations

Differential effect of d-fenfluramine and metergoline on food intake in human subjects

1988 • 30 citations

MicroComputers, Psychology and Medicine

1990 • 30 citations

Effects of Tryptophan and of 5-Hydroxytryptamine Receptor Subtype Agonists on Feeding

1991 • 28 citations

Evidence for the involvement of the 5-HT1A receptor in CCK induced satiety in rats

1995 • 28 citations

Clinical studies with d-fenfluramine

1992 • 27 citations

The role of hypothalamic peptides in the control of energy balance and body weight

1996 • 26 citations

d-Fenfluramine in a rat model of dietary fat-induced obesity

1993 • 26 citations

CONTROL OF BRAIN 5-HT CONTENT BY DIETARY CARBOHYDRATES

1973 • 25 citations

The clinical pharmacology of appetite suppressant drugs.

1984 • 23 citations

Drug therapy after very-low-calorie diets

1992 • 23 citations

Hyperphagia following intraventricular p-chlorophenylalanine-, leucine- or tryptophan-methyl esters: Lack of correlation with whole brain serotonin levels

1979 • 23 citations

The effect of d-fenfluramine on intake of carbohydrate supplements is influenced by the hydration of the test diets

1992 • 22 citations

5-HT manipulation and dietary choice: variable carbohydrate (Polycose) suppression demonstrated only under specific experimental conditions

1993 • 22 citations

Comparisons between the effects of 5-HT and dl-fenfluramine on food intake and gastric emptying in the rat

1995 • 21 citations

Effects of the 5-HT uptake inhibitors, femoxetine and paroxetine, and a 5-HT1A/B agonist, eltoprazine, on the behavioural satiety sequence

1992 • 20 citations

Intraventricular but not intraparaventricular nucleus metergoline elicits feeding in satiated rats

1994 • 20 citations

Evidence that 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane-induced hypophagia and hyperthermia in rats is mediated by serotonin-2A receptors.

1994 • 20 citations

Studies on the role of 5-HT receptors in satiation and the effect of d-fenfluramine in the runway test

1990 • 18 citations

Death from irreversible pulmonary hypertension associated with short-term use of fenfluramine and phentermine.

1997 • 11 citations

High altitude may be synergistic with pulmonary hazards of appetite control medications fenfluramine and dexfenfluramine

1997 • 1 citations

Deleted Work

1955 • 0 citations