Time‐dependent effects of theophylline on myocardial reactive hyperaemias in the anaesthetized dog

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1986 • 1,413 citations

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1981 • 705 citations

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1983 • 454 citations

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1985 • 449 citations

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1975 • 427 citations

Are methylxanthine effects due to antagonism of endogenous adenosine?

1979 • 419 citations

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1947 • 370 citations

Theophylline A “State of the Art” Review

1983 • 337 citations

Clinical Pharmacokinetics

1975 • 298 citations

Release of adenosine in reactive hyperemia of the dog heart

1969 • 261 citations

Kinetics of pharmacologic effects in man: The anticoagulant action of warfarin

1969 • 230 citations

The coronary endothelium: a highly active metabolic barrier for adenosine

1985 • 207 citations

Kinetics of pharmacologic effects

1966 • 195 citations

Endothelium-Removal Decreases Relaxations of Canine Coronary Arteries Caused by β-Adrenergic Agonists and Adenosine

1985 • 194 citations

Relationship Between Drug Concentration in Plasma or Serum and Amount of Drug in the Body

1969 • 179 citations

Endothelium‐dependent relaxation of the pig aorta: relationship to stimulation of ⁸⁶Rb efflux from isolated endothelial cells

1983 • 166 citations

Concept of a Volume of Distribution and Possible Errors in Evaluation of This Parameter

1968 • 164 citations

Pharmacokinetic analysis of the effect of the ophylline on pulmonary function in asthmatic children

1975 • 144 citations

Evidence for an adenosine receptor on the surface of dog coronary myocytes.

1976 • 130 citations

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1975 • 127 citations

Regulation of postocclusive hyperemia by endogenously synthesized prostaglandins in the dog heart.

1975 • 124 citations

Rapidly achieved plasma concentration plateaus, with observations on theophylline kinetics

1972 • 117 citations

Prostaglandins and the control of blood flow in the canine myocardium.

1977 • 111 citations

Methyl xanthine phosphodiesterase inhibitors behave as prostaglandin antagonists in a perfused rat mesenteric artery preparation

1977 • 109 citations

Evidence for a cell surface adenosine receptor on coronary myocytes and atrial muscle cells

1977 • 106 citations

Apparent volumes of distribution and drug binding to plasma proteins and tissues

1978 • 102 citations

Adenosine metabolism in canine myocardial reactive hyperemia.

1978 • 92 citations

Effect of theophylline and other drugs on rabbit renal cyclic nucleotide phosphodiesterase, 5′-nucleotidase and adenosine deaminase

1978 • 88 citations

Consistent parallel relationships among myocardial oxygen consumption, coronary blood flow, and pericardial infusate adenosine concentration with various interventions and beta-blockade in the dog.

1983 • 69 citations

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1971 • 67 citations

Multicompartment Pharmacokinetic Models and Pharmacologic Effects

1969 • 62 citations

Pharmacokinetics of Drug Action

1972 • 61 citations

The importance of tissue distribution in pharmacokinetics

1973 • 60 citations

Reactive hyperaemia in the dog heart: inter-relations between adenosine, ATP, and aminophylline and the effect of indomethacin

1977 • 59 citations

Myocardial reactive hyperemia responses in the dog after aminophylline and lidoflazine

1971 • 45 citations

Pharmacological and biochemical activities of some monomethylxanthine and methyluric acid derivatives of theophylline and caffeine

1978 • 31 citations

MYOCARDIAL REACTIVE HYPERAEMIA IN CONSCIOUS DOGS: EFFECT OF DIPYRIDAMOLE AND AMINOPHYLLINE ON RESPONSES TO FOUR‐ AND EIGHT‐SECOND CORONARY ARTERY OCCLUSIONS

1973 • 17 citations

�ber die Permeation von Xanthinderivaten in Gehirn und Liquor in Abh�ngigkeit von Lipoidl�slichkeit, Gewebsbindung und Stoffwechsel

1968 • 17 citations

Effect of cyclic AMP phosphodiesterase inhibitors on cardiac sarcolemmal 5'-nucleotidase.

1981 • 15 citations

Possible role of prostaglandins in the regulation of coronary blood flow

1981 • 15 citations

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1974 • 14 citations

Effect of aminophylline on coronary reactive and functional hyperaemic response in conscious dogs

1984 • 10 citations

Role of adenosine in postocclusion coronary vasodilation

1980 • 8 citations

Intracoronary adenosine enhances myocardial reactive hyperemia after brief coronary occlusion

1985 • 7 citations