Age-associated chronic diseases require age-old medicine: Role of chronic inflammation

The Hallmarks of Cancer

2000 • 27,569 citations

Immunity, Inflammation, and Cancer

2010 • 9,544 citations

International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels

2003 • 7,170 citations

Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling

2017 • 5,610 citations

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1999 • 4,973 citations

C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus

2001 • 4,289 citations

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

TLR4 links innate immunity and fatty acid–induced insulin resistance

2006 • 3,422 citations

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1999 • 3,344 citations

Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence

1992 • 3,313 citations

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

1986 • 2,771 citations

Adipose Tissue, Inflammation, and Cardiovascular Disease

2005 • 2,021 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

2002 • 1,849 citations

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

1998 • 1,740 citations

Molecular targets of dietary agents for prevention and therapy of cancer

2006 • 1,711 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Nuclear factor-κB

2004 • 1,545 citations

Pharmacology of oleanolic acid and ursolic acid

1995 • 1,394 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets

2008 • 1,047 citations

International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors

2006 • 974 citations

Hydroxylation of HIF-1: Oxygen Sensing at the Molecular Level

2004 • 889 citations

Dietary Intake and Risk of Developing Inflammatory Bowel Disease: A Systematic Review of the Literature

2011 • 886 citations

Non–HDL Cholesterol, Apolipoproteins A-I and B₁₀₀, Standard Lipid Measures, Lipid Ratios, and CRP as Risk Factors for Cardiovascular Disease in Women

2005 • 743 citations

NF- B as a Critical Link Between Inflammation and Cancer

2009 • 736 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances

1999 • 649 citations

Persistently Activated Stat3 Maintains Constitutive NF-κB Activity in Tumors

2009 • 605 citations

Peroxisome Proliferator-Activated Receptor Gamma Activators Inhibit Gene Expression and Migration in Human Vascular Smooth Muscle Cells

1998 • 594 citations

Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκB

2007 • 578 citations

Soybean Isoflavones Improve Cardiovascular Risk Factors without Affecting the Reproductive System of Peripubertal Rhesus Monkeys

1996 • 542 citations

PPARs and molecular mechanisms of transrepression

2007 • 531 citations

Constitutive activation of Stat3 in human prostate tumors and cell lines: direct inhibition of Stat3 signaling induces apoptosis of prostate cancer cells.

2002 • 526 citations

Resveratrol: A multitargeted agent for age-associated chronic diseases

2008 • 522 citations

Inflammation and the Degenerative Diseases of Aging

2004 • 515 citations

Ca2+/Calmodulin-dependent Protein Kinase II Is Stimulated by Wnt and Frizzled Homologs and Promotes Ventral Cell Fates in Xenopus

2000 • 497 citations

Healthy Living Is the Best Revenge

2009 • 482 citations

Vegetables, fruits, legumes and prostate cancer: a multiethnic case-control study.

2000 • 478 citations

Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals

2010 • 440 citations

Whole‐grain intake and cancer: An expanded review and meta‐analysis

1998 • 423 citations

Wnt/β-catenin signaling

2000 • 421 citations

Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives

2005 • 415 citations

A prospective study of consumption of carotenoids in fruits and vegetables and decreased cardiovascular mortality in the elderly

1995 • 380 citations

NF-κB and cancer: how intimate is this relationship

2009 • 371 citations

Plant foods in the management of diabetes mellitus: Spices as beneficial antidiabetic food adjuncts

2005 • 364 citations

Fruits and vegetables in the prevention of cancer and cardiovascular disease

2000 • 360 citations

Inflammatory markers in late-life depression: Results from a population-based study

2007 • 321 citations

Beneficial health effects of lupeol triterpene: A review of preclinical studies

2010 • 319 citations

Role of redox-regulated transcription factors in inflammation, aging and age-related diseases

2000 • 299 citations

Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase

1994 • 294 citations

Oxidative Stress, Chromatin Remodeling and Gene Transcription in Inflammation and Chronic Lung Diseases

2003 • 292 citations

Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF- B activation through inhibition of I B kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1

2003 • 288 citations

Are vitamin and mineral deficiencies a major cancer risk?

2002 • 287 citations

Two-Sided Roles of IL-27: Induction of Th1 Differentiation on Naive CD4+ T Cells versus Suppression of Proinflammatory Cytokine Production Including IL-23-Induced IL-17 on Activated CD4+ T Cells Partially Through STAT3-Dependent Mechanism

2006 • 244 citations

Cytokine mRNA expression in inflammatory multiple sclerosis lesions: Detection by non-radioactive in situ hybridization

1993 • 239 citations

Whole grain food intake and cancer risk

1998 • 237 citations

Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells

2007 • 232 citations

Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease

1997 • 228 citations

Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells

2003 • 222 citations

Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986. 46: 705-716.

2006 • 219 citations

Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells

2004 • 214 citations

Carotenoids in cancer chemoprevention.

2002 • 205 citations

Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-κB, AP-1, JNK, MAPKK and apoptosis

2000 • 204 citations

STATs Dimerize in the Absence of Phosphorylation

2003 • 202 citations

Isoflavone Genistein: Photoprotection and Clinical Implications in Dermatology

2003 • 197 citations

An Oat-Containing Hypocaloric Diet Reduces Systolic Blood Pressure and Improves Lipid Profile beyond Effects of Weight Loss in Men and Women

2001 • 193 citations

Nutritional factors in the aetiology of multiple sclerosis: a case- control study in Montreal, Canada

1998 • 192 citations

Anti-inflammatory and Anti-oxidant Properties of Curcuma longa (Turmeric) Versus Zingiber officinale (Ginger) Rhizomes in Rat Adjuvant-Induced Arthritis

2010 • 174 citations

Activation of Stat3 in v-Src-transformed Fibroblasts Requires Cooperation of Jak1 Kinase Activity

2000 • 168 citations

Hypoglycaemic activity of two spices extracts: Rhus coriaria L. and Bunium persicum Boiss

2006 • 150 citations

The function of Stat3 in tumor cells and their microenvironment

2008 • 148 citations

Ursolic acid induces apoptosis through mitochondrial intrinsic pathway and caspase-3 activation in M4Beu melanoma cells

2004 • 147 citations

Effect of 6-Gingerol on Pro-Inflammatory Cytokine Production and Costimulatory Molecule Expression in Murine Peritoneal Macrophages

2007 • 144 citations

Differential inflammatory responses in aging and disease: TNF-α and IL-6 as possible biomarkers

2010 • 141 citations

Neuroprotection by Spice-Derived Nutraceuticals: You Are What You Eat!

2011 • 141 citations

Raw and Cooked Vegetables, Fruits, Selected Micronutrients, and Breast Cancer Risk: A Case-Control Study in Germany

2003 • 137 citations

Cereal fiber and whole-grain intake are associated with reduced progression of coronary-artery atherosclerosis in postmenopausal women with coronary artery disease

2005 • 137 citations

Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study

2010 • 133 citations

STAT3 mediates IL-6-induced growth inhibition in the human prostate cancer cell line LNCaP

2000 • 133 citations

Expression levels of the JAK/STAT pathway in the transition from hormone-sensitive to hormone-refractory prostate cancer

2007 • 129 citations

Tumour reducing and anticarcinogenic activity of selected spices

1990 • 129 citations

Nuclear Factor-kB Tumor Expression Predicts Response and Survival in Irinotecan-Refractory Metastatic Colorectal Cancer Treated With Cetuximab-Irinotecan Therapy

2007 • 124 citations

Prevention of Type 2 Diabetes by Dietary Patterns: A Systematic Review of Prospective Studies and Meta-Analysis

2010 • 124 citations

Cross-Talk Between IL-1 and IL-6 Signaling Pathways in Rheumatoid Arthritis Synovial Fibroblasts

2001 • 113 citations

Suppression of age-related inflammatory NF-κB activation by cinnamaldehyde

2007 • 111 citations

PPAR‐γ Agonists and Their Effects on IGF‐I Receptor Signaling: Implications for Cancer

2009 • 111 citations

Transcription Factor NF-kB and Inhibitor kBα are Localized in Macrophages in Active Multiple Sclerosis Lesions

1998 • 110 citations

Ursolic acid inhibits proliferation and stimulates apoptosis in HT29 cells following activation of alkaline sphingomyelinase.

2003 • 108 citations

Encounters with Fos and Jun on the road to AP-1.

1990 • 107 citations

Reversal of aging by NFκB blockade

2008 • 100 citations

Inhibitory effect of ursolic acid on B16 proliferation through cell cycle arrest

1996 • 96 citations

Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives

2008 • 93 citations

Pro-Inflammatory Enzymes, Cyclooxygenase 1, Cyclooxygenase 2, and 5-Lipooxygenase, Inhibited by Stabilized Rice Bran Extracts

2009 • 91 citations

Transgenic Flavonoid Tomato Intake Reduces C-Reactive Protein in Human C-Reactive Protein Transgenic Mice More Than Wild-Type Tomato

2006 • 84 citations

Food selection based on high total antioxidant capacity improves endothelial function in a low cardiovascular risk population

2010 • 84 citations

Breakfast Cereals and Risk of Type 2 Diabetes in the Physicians’ Health Study I

2007 • 83 citations

Clinical Importance and Therapeutic Implications of the Pivotal CXCL12-CXCR4 (Chemokine Ligand-Receptor) Interaction in Cancer Cell Migration

2007 • 80 citations

Atypical pathways of NF-κB activation and aging

2009 • 74 citations

Clinical and pathologic significance of activation of signal transducer and activator of transcription 3 in prostate cancer

2005 • 73 citations

Pro-inflammatory cytokines and prostate-specific antigen in hyperplasia and human prostate cancer

2008 • 71 citations

Ursolic acid overcomes Bcl‐2‐mediated resistance to apoptosis in prostate cancer cells involving activation of JNK‐induced Bcl‐2 phosphorylation and degradation

2010 • 57 citations

C-reactive protein increases plasminogen activator inhibitor-1 expression in human endothelial cells

2007 • 54 citations

Does diet have a role in the aetiology of rheumatoid arthritis?

2004 • 52 citations

PPARαActivation by Culinary Herbs and Spices

2010 • 48 citations

Abnormalities of Vasomotor Regulation in the Pathogenesis of the Acute Charcot Foot of Diabetes Mellitus

2005 • 41 citations

A flame burning within

2004 • 40 citations

The cyclooxygenase‐2 pathway via the PGE₂ EP2 receptor contributes to oligodendrocytes apoptosis in cuprizone‐induced demyelination

2011 • 40 citations

Black Soy Peptide Supplementation Improves Glucose Control in Subjects with Prediabetes and Newly Diagnosed Type 2 Diabetes Mellitus

2010 • 38 citations

Interleukin-6 is a Major Myeloma Cell Growth Factor In Vitro and In Vivo Especially in Patients with Terminal Disease

1990 • 36 citations

Elevated C-reactive protein: a common marker for atherosclerotic cardiovascular risk and subclinical stages of pulmonary dysfunction and osteopenia in a healthy population

2004 • 36 citations

Proteomic analysis of ursolic acid-induced apoptosis in cervical carcinoma cells

2005 • 35 citations

Aging Linked to Type 2 Diabetes Increases Oxidative Stress and Chronic Inflammation

2011 • 28 citations

Understanding inflammatory bowel disease-the clinician's perspective

2001 • 28 citations

Inflammation in Cardiovascular Disease and Regulation of the Actin Cytoskeleton in Inflammatory Cells: The Actin Cytoskeleton as a Target

2006 • 26 citations

Amelioration of experimental autoimmune encephalitis by novel peptides: Involvement of T regulatory cells

2010 • 26 citations

Oncogenic transformation by Jun: role of transactivation and homodimerization.

1992 • 25 citations

Pro-Inflammatory Cytokines in Elective Flap Surgery

2006 • 17 citations

Effect of inositol hexaphosphate on the development of UVB-induced skin tumors in SKH1 hairless mice.

2009 • 16 citations

Chemopreventive action of oriental food‐seasoning spices mixture garam masala on DMBA‐induced transplacental and translactational carcinogenesis in mice

1995 • 14 citations

Effect of a vegetable-protein-rich polymeric diet treatment on body composition and energy metabolism in inactive Crohnʼs disease

2000 • 10 citations

Inflammation: An Expanding Universe

2008 • 6 citations