Reversal of aging by NFκB blockade

Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase

2004 • 2,531 citations

Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors

2005 • 2,212 citations

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

2005 • 2,118 citations

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

2002 • 2,057 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Gene regulation and DNA damage in the ageing human brain

2004 • 1,826 citations

IKK-β links inflammation to obesity-induced insulin resistance

2005 • 1,710 citations

Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue

2003 • 1,328 citations

The Plasticity of Aging: Insights from Long-Lived Mutants

2005 • 1,319 citations

Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction

2006 • 1,259 citations

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

2002 • 1,150 citations

Circuitry of nuclear factor κB signaling

2006 • 861 citations

Calorie Restriction— the SIR2 Connection

2005 • 794 citations

Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence

1982 • 757 citations

Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

2007 • 757 citations

SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

2005 • 718 citations

Sirtuins in Aging and Age-Related Disease

2006 • 613 citations

Increased cell-to-cell variation in gene expression in ageing mouse heart

2006 • 587 citations

Demography of Dietary Restriction and Death in Drosophila

2003 • 531 citations

Comparing genomic expression patterns across species identifies shared transcriptional profile in aging

2004 • 446 citations

Motif module map reveals enforcement of aging by continual NF-κB activity

2007 • 439 citations

AGEMAP: A Gene Expression Database for Aging in Mice

2007 • 430 citations

Regulation of NF-κB, Th Activation, and Autoinflammation by the Forkhead Transcription Factor Foxo3a

2004 • 407 citations

Resistance Exercise Reverses Aging in Human Skeletal Muscle

2007 • 318 citations

Temporal linkage between the phenotypic and genomic responses to caloric restriction

2004 • 261 citations

Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-κB

1996 • 234 citations

Genome-wide Mapping of RELA(p65) Binding Identifies E2F1 as a Transcriptional Activator Recruited by NF-κB upon TLR4 Activation

2007 • 178 citations

Aging and Gene Expression in the Primate Brain

2005 • 172 citations

Modelling cancer in human skin tissue

2006 • 140 citations

Age-related changes in the regulation of transcription factor NF-κB in rat brain

1997 • 139 citations

Age of ovary determines remaining life expectancy in old ovariectomized mice

2003 • 134 citations

Involvement of Rel/Nuclear Factor-κB Transcription Factors in Keratinocyte Senescence

2004 • 104 citations

Transcriptional Networks and Cellular Senescence in Human Mammary Fibroblasts

2004 • 69 citations

CDK4 regulation by TNFR1 and JNK is required for NF-κB–mediated epidermal growth control

2005 • 60 citations

Microarrays as a Tool to Investigate the Biology of Aging: A Retrospective and a Look to the Future

2004 • 38 citations