Alternative binding modes of an inhibitor to two different kinases

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

The Protein Kinase Complement of the Human Genome

2002 • 7,708 citations

MOLREP: an Automated Program for Molecular Replacement

1997 • 4,644 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 3,002 citations

Protein kinases — the major drug targets of the twenty-first century?

2002 • 2,101 citations

Improved Fourier coefficients for maps using phases from partial structures with errors

1986 • 1,897 citations

The integration of macromolecular diffraction data

2005 • 1,343 citations

One‐thousand‐and‐one substrates of protein kinase CK2?

2003 • 1,292 citations

Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase Inhibitors

1998 • 792 citations

The Nature and Geometry of Intermolecular Interactions between Halogens and Oxygen or Nitrogen

1996 • 785 citations

Mechanisms of cyclin-dependent kinase regulation: structures of cdks, their cyclin activators, and cip and INK4 inhibitors

1999 • 703 citations

An approach to multi-copy search in molecular replacement

2000 • 700 citations

Inhibition of Cyclin‐Dependent Kinases by Purine Analogues

1997 • 680 citations

Structural basis of cyclin-dependent kinase activation by phosphorylation

1996 • 585 citations

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

1999 • 533 citations

Pharmacological inhibitors of cyclin-dependent kinases

2002 • 528 citations

Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase.

1996 • 477 citations

Sequence‐structure analysis of FAD‐containing proteins

2001 • 445 citations

Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme

2001 • 420 citations

Integration of macromolecular diffraction data

1999 • 404 citations

Selectivity of 4,5,6,7‐tetrabromobenzotriazole, an ATP site‐directed inhibitor of protein kinase CK2 (‘casein kinase‐2’)

2001 • 346 citations

A role for casein kinase 2α in the Drosophila circadian clock

2002 • 330 citations

Protein kinase CK2 (“casein kinase-2”) and its implication in cell division and proliferation

1997 • 320 citations

IsoStar: a library of information about nonbonded interactions.

1997 • 311 citations

Multiple modes of ligand recognition: Crystal structures of cyclin‐dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine

1995 • 273 citations

Perspectives on the development of a molecularly targeted agent

2002 • 267 citations

Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

1999 • 248 citations

Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor

2002 • 210 citations

Structural Basis for Chk1 Inhibition by UCN-01

2002 • 204 citations

Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1Aresolution

1998 • 198 citations

High-Resolution Crystal Structures of Human Cyclin-Dependent Kinase 2 with and without ATP: Bound Waters and Natural Ligand as Guides for Inhibitor Design

1996 • 197 citations

GTP plus water mimic ATP in the active site of protein kinase CK2.

1999 • 178 citations

Specificity Determinants of Recruitment Peptides Bound to Phospho-CDK2/Cyclin A^,

2002 • 157 citations

Structural features underlying selective inhibition of protein kinase CK2 by ATP site‐directed tetrabromo‐2‐benzotriazole

2001 • 154 citations

Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential

1997 • 150 citations

Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine 1 1Edited by I. A. Wilson

1999 • 138 citations

Flavopiridol Inhibits Glycogen Phosphorylase by Binding at the Inhibitor Site

2000 • 125 citations

ATP site-directed competitive and irreversible inhibitors of protein kinases

2000 • 117 citations

Structural aspects of protein kinase control—role of conformational flexibility

2002 • 90 citations

Structure of human transthyretin complexed with bromophenols: a new mode of binding

2000 • 76 citations

Use of Kinase Inhibitors to Dissect Signaling Pathways

2003 • 72 citations

Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2

2002 • 67 citations

Crystal Structure of Human Cyclin-Dependent Kinase 2 in Complex with the Adenine-Derived Inhibitor H717

2000 • 61 citations

Progress in Cell Cycle Research

2000 • 42 citations

Quantitative analysis of hydrogen bonding and atomic thermal motion in the organic non-linear optical material DCNP using X-ray and neutron diffraction

2000 • 27 citations

A role for casein kinase 2a in the Drosophila circadian clock

2002 • 23 citations

Bis-Triiodide von 1,2-Ethandiaminkomplexen am Beispiel des Metalls Kupfer

2000 • 10 citations