Structural studies with inhibitors of the cell cycle regulatory kinase cyclin-dependent protein kinase 2

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors

1997 • 2,201 citations

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

1993 • 1,531 citations

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1995 • 1,407 citations

Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor

1998 • 968 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

Mechanisms of cyclin-dependent kinase regulation: structures of cdks, their cyclin activators, and cip and INK4 inhibitors

1999 • 703 citations

Structural Basis for Control by Phosphorylation

2001 • 600 citations

Structural basis of cyclin-dependent kinase activation by phosphorylation

1996 • 585 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

The Chk1 Protein Kinase and the Cdc25C Regulatory Pathways Are Targets of the Anticancer Agent UCN-01

2000 • 548 citations

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

1999 • 533 citations

Preclinical and Clinical Development of Cyclin-Dependent Kinase Modulators

2000 • 501 citations

UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53

1996 • 451 citations

Anticancer drug targets: cell cycle and checkpoint control

1999 • 441 citations

Phase I Trial of 72-Hour Continuous Infusion UCN-01 in Patients With Refractory Neoplasms

2001 • 295 citations

Different Susceptibility of Protein Kinases to Staurosporine Inhibition

1995 • 284 citations

Crystal Structure of the Catalytic Domain of the Human Cell Cycle Control Phosphatase, Cdc25A

1998 • 282 citations

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia

2000 • 258 citations

Chemical inhibitors of cyclin-dependent kinases

1996 • 251 citations

Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.

1997 • 241 citations

An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage.

2000 • 231 citations

Effects of Phosphorylation of Threonine 160 on Cyclin-dependent Kinase 2 Structure and Activity

1999 • 219 citations

Unpredicted clinical pharmacology of UCN-01 caused by specific binding to human alpha1-acid glycoprotein.

1998 • 198 citations

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia

2000 • 193 citations

Implications for Chk1 Regulation: The 1.7 Å Crystal Structure of Human Cell Cycle Checkpoint Kinase Chk1

2000 • 192 citations

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

1987 • 189 citations

The crystal structure of cyclin A

1995 • 186 citations

Phosphoprotein–Protein Interactions Revealed by the Crystal Structure of Kinase-Associated Phosphatase in Complex with PhosphoCDK2

2001 • 174 citations

Dephosphorylation of Cdk2 Thr ¹⁶⁰ by the Cyclin-Dependent Kinase-Interacting Phosphatase KAP in the Absence of Cyclin

1995 • 170 citations

Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.

1994 • 161 citations

KAP: a dual specificity phosphatase that interactswith cyclin-dependent kinases.

1994 • 147 citations

Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2.

1995 • 137 citations

UCN-01, 7-Hydroxyl-staurosporine, Inhibits Kinase Activity of Cyclin-Dependent Kinases and Reduces the Phosphorylation of the Retinoblastoma Susceptibility Gene Product in A549 Human Lung Cancer Cell Line

1996 • 117 citations

Absolute Configuration of Staurosporine By X-Ray Analysis

1994 • 98 citations

Dephosphorylation of Human Cyclin-dependent Kinases by Protein Phosphatase Type 2Cα and β2 Isoforms

2000 • 96 citations

Structure-based design of cyclin-dependent kinase inhibitors

2002 • 94 citations

Analogs of Staurosporine

1998 • 92 citations

UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G2 checkpoint abrogation

2000 • 89 citations

7-Hydroxystaurosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S-phase arrest in Chinese hamster ovary cells.

1997 • 74 citations

Old and new therapies in chronic lymphocytic leukemia: now is the time for a reassessment of therapeutic goals.

1998 • 58 citations

A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine) I. Screening, taxonomy, fermentation and biological activity.

1990 • 41 citations

Comparison of the efficacy of 7-hydroxystaurosporine (UCN-01) and other staurosporine analogs to abrogate cisplatin-induced cell cycle arrest in human breast cancer cell lines

1999 • 40 citations

Purification, Characterization, and Kinetic Mechanism of Cyclin D1·CDK4, a Major Target for Cell Cycle Regulation

1998 • 40 citations

Tesla's sparks of imagination

1993 • 15 citations