Protein kinase CK2 (“casein kinase-2”) and its implication in cell division and proliferation
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References (194)
Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.
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Casein kinase 2: An ‘eminence grise’ in cellular regulation?
1990 • 920 citations
Mitosis in transition
1994 • 745 citations
GENETIC CONTROL OF THE CELL DIVISION CYCLE IN YEAST: V. GENETIC ANALYSIS OF cdc MUTANTS
1973 • 728 citations
Use of an oriented peptide library to determine the optimal substrates of protein kinases
1994 • 645 citations
Inhibition of Cyclin‐Dependent Kinases by Purine Analogues
1994 • 625 citations
Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation
1995 • 622 citations
Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution
1994 • 591 citations
A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1
1996 • 555 citations
How do protein kinases recognize their substrates?
1996 • 470 citations
Protein Serine/Threonine Phosphatases—New Avenues for Cell Regulation
1994 • 424 citations
Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).
1993 • 399 citations
Casein Kinase IIα Transgene-Induced Murine Lymphoma: Relation to Theileriosis in Cattle
1995 • 384 citations
Isolation, sequencing, and disruption of the yeast CKA2 gene: casein kinase II is essential for viability in Saccharomyces cerevisiae.
1990 • 365 citations
Three protein kinase structures define a common motif
1994 • 364 citations
Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha.
1996 • 289 citations
Different Susceptibility of Protein Kinases to Staurosporine Inhibition
1995 • 284 citations
Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals
1993 • 272 citations
Casein kinases: pleiotropic mediators of cellular regulation
1993 • 264 citations
Nuclear import-export: In search of signals and mechanisms
1991 • 233 citations
Casein Kinase II Is Required for Cell Cycle Progression during G1 and G2/M in Saccharomyces cerevisiae
1995 • 226 citations
Synergistic phosphorylation and activation of ATP-Mg-dependent phosphoprotein phosphatase by F A/GSK-3 and casein kinase II (PC0.7).
1984 • 212 citations
Casein kinase II is elevated in solid human tumours and rapidly proliferating non‐neoplastic tissue
1990 • 211 citations
Casein kinase II is a predominantly nuclear enzyme.
1992 • 208 citations
Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail.
1995 • 184 citations
Studies on the kinetic mechanism of the catalytic subunit of the cAMP-dependent protein kinase.
1983 • 183 citations
Casein kinase II is required for transition of G0/G1, early G1, and G1/S phases of the cell cycle.
1994 • 172 citations
Serum-stimulated cell growth causes oscillations in casein kinase II activity
1989 • 171 citations
Casein kinase II in signal transduction and cell cycle regulation
1993 • 170 citations
Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.
1994 • 165 citations
Asymmetric Expression of Protein Kinase CK2 Subunits in Human Kidney Tumors
1994 • 163 citations
Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2.
1993 • 162 citations
Constitutive phosphorylation of I kappa B alpha by casein kinase II.
1995 • 160 citations
Genetic analysis of cell morphogenesis in fission yeast--a role for casein kinase II in the establishment of polarized growth.
1994 • 159 citations
Role of the β subunit of casein kinase‐2 on the stability and specificity of the recombinant reconstituted holoenzyme
1992 • 157 citations
Fibroblast Growth Factor-2 Binds to the Regulatory β Subunit of CK2 and Directly Stimulates CK2 Activity toward Nucleolin
1996 • 152 citations
Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2.
1991 • 149 citations
Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product
1995 • 148 citations
Phosphorylation of casein kinase II by p34cdc2 in vitro and at mitosis.
1992 • 139 citations
Casein Kinase 2 Down-Regulation and Activation by Polybasic Peptides Are Mediated by Acidic Residues in the 55-64 Region of the .beta.-Subunit. A Study with Calmodulin As Phosphorylatable Substrate
1994 • 139 citations
Interactions between the Subunits of Casein Kinase II
1995 • 137 citations
Halogenated Benzimidazoles and Benzotriazoles as Selective Inhibitors of Protein Kinases CK-I and CK-II from Saccharomyces Cerevisiae and Other Sources
1995 • 127 citations
The effect of polylysine on casein‐kinase‐2 activity is influenced by both the structure of the protein/peptide substrates and the subunit composition of the enzyme
1992 • 125 citations
Protein Kinase CK2 Mutants Defective in Substrate Recognition
1996 • 124 citations
Casein kinase II and the tumor suppressor protein P53 associate in a molecular complex that is negatively regulated upon P53 phosphorylation.
1992 • 122 citations
Cell cycle oscillation of phosphatase inhibitor-2 in rat fibroblasts coincident with p34cdc2 restriction
1990 • 120 citations
Nuclear casein kinase 2 (CK‐2) activity in human normal, benign hyperplastic, and cancerous prostate
1994 • 119 citations
Casein kinase II phosphorylates p34cdc2 kinase in G1 phase of the HeLa cell division cycle.
1992 • 119 citations
Interaction between casein kinase II and the 90-kDa stress protein, HSP90
1995 • 117 citations
Molecular Cloning of NIPP-1, a Nuclear Inhibitor of Protein Phosphatase-1, Reveals Homology with Polypeptides Involved in RNA Processing
1995 • 115 citations
Ribofuranosyl‐benzimidazole derivatives as inhibitors of casein kinase‐2 and casein kinase‐1
1990 • 115 citations
Enhanced casein kinase II activity during mouse embryogenesis
1986 • 114 citations
The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation.
1995 • 113 citations
A filamentous form of Drosophila casein kinase II.
1986 • 112 citations
Casein kinase II from Caenorhabditis elegans. Properties and developmental regulation of the enzyme; cloning and sequence analyses of cDNA and the gene for the catalytic subunit.
1990 • 109 citations
Phosphorylation of the human estrogen receptor by mitogen-activated protein kinase and casein kinase II: Consequence on DNA binding
1995 • 109 citations
Phosphorylation of the MADS-Box Transcription Factor MEF2C Enhances Its DNA Binding Activity
1996 • 108 citations
The Ste locus, a component of the parasitic cry-Ste system of Drosophila melanogaster, encodes a protein that forms crystals in primary spermatocytes and mimics properties of the beta subunit of casein kinase 2.
1995 • 108 citations
Reconstitution of normal and hyperactivated forms of casein kinase-2 by variably mutated .beta.-subunits
1993 • 105 citations
Human‐immundeficiency‐virus‐type‐1‐encoded Vpu protein is phosphorylated by casein kinase II
1992 • 104 citations
A‐Raf kinase is a new interacting partner of protein kinase CK2 β subunit
1997 • 101 citations
Phosphorylation of VAMP/Synaptobrevin in Synaptic Vesicles by Endogenous Protein Kinases
1995 • 100 citations
Phosphorylation of C8 and C9 Subunits of the Multicatalytic Proteinase by Casein Kinase II and Identification of the C8 Phosphorylation Sites by Direct Mutagenesis
1996 • 100 citations
The Schizosaccharomyces pombe casein kinase II alpha and beta subunits: evolutionary conservation and positive role of the beta subunit.
1994 • 98 citations
Casein kinase II. cDNA sequences, developmental expression, and tissue distribution of mRNAs for alpha, alpha', and beta subunits of the chicken enzyme
1991 • 98 citations
Subunit structure and autophosphorylation mechanism of casein kinase-TS (type-2) from rat liver cytosol
1984 • 97 citations
Reconstitution of Arabidopsis casein kinase II from recombinant subunits and phosphorylation of transcription factor GBF1.
1995 • 97 citations
Quaternary Structure of Casein Kinase 2
1995 • 94 citations
Evidence for the induction of casein kinase II in bovine lymphocytes transformed by the intracellular protozoan parasite Theileria parva.
1993 • 94 citations
Biosynthesis of casein kinase II in lymphoid cell lines
1994 • 93 citations
Cloning and Disruption of CKB1, the Gene Encoding the 38-kDa β Subunit of Saccharomyces cerevisiae Casein Kinase II (CKII)
1995 • 92 citations
Casein Kinase II Phosphorylates the Neural Cell Adhesion Molecule L1
1996 • 91 citations
Basal Phosphorylation of the PEST Domain in IκBβ Regulates Its Functional Interaction with the c-rel Proto-Oncogene Product
1996 • 91 citations
Molecular Cloning of Casein Kinase II a Subunit from Dictyostelium discoideum and Its Expression in the Life Cycle
1992 • 90 citations
Casein kinase II preferentially phosphorylates human tau isoforms containing an amino-terminal insert. Identification of threonine 39 as the primary phosphate acceptor.
1994 • 89 citations
Comparison of the Rat Nucleolar Protein Nopp140 with Its Yeast Homolog SRP40
1996 • 89 citations
The Physical Association of Casein Kinase 2 with Nucleolin
1996 • 86 citations
Rat Liver Golgi Apparatus Contains a Protein Kinase Similar to the Casein Kinase of Lactating Mammary Gland
1997 • 84 citations
Golgi apparatus mammary gland casein kinase: monitoring by a specific peptide substrate and definition of specificity determinants
1996 • 84 citations
The consensus sequences for cdc2 kinase and for casein kinase‐2 are mutually incompatible A study with peptides derived from the β‐subunit of casein kinase‐2
1992 • 84 citations
Casein Kinase II Increases the Transcriptional Activities of MRF4 and MyoD Independently of Their Direct Phosphorylation
1996 • 84 citations
Phosphorylated synthetic peptides as tools for studying protein phosphatases
1994 • 83 citations
Cell cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis
1995 • 83 citations
Identification of phosphorylation sites unique to the B form of human progesterone receptor. In vitro phosphorylation by casein kinase II.
1994 • 80 citations
GRP94 resides within cardiac sarcoplasmic reticulum vesicles and is phosphorylated by casein kinase II.
1994 • 79 citations
Expression of wild-type and mutated forms of the catalytic (alpha) subunit of Caenorhabditis elegans casein kinase II in Escherichia coli
1990 • 78 citations
Regulation of topoisomerase II by phosphorylation: a role for casein kinase II
1993 • 77 citations
Functional Regulation of Thyroid Hormone Receptor Variant TRα2 by Phosphorylation
1995 • 75 citations
Involvement of Cellular Casein Kinase II in the Phosphorylation of Measles Virus P Protein: Identification of Phosphorylation Sites
1995 • 74 citations
Purification and characterization of a casein‐kinase‐II‐type enzyme from Xenopus laevis ovary
1988 • 73 citations
Characterization in Mammalian Brain of a DARPP‐32 Serine Kinase Identical to Casein Kinase II
1990 • 72 citations
Autophosphorylation of type 2 casein kinase TS at both its α‐ and β‐subunits
1983 • 70 citations
Isolation of phosphorylated calmodulin from rat liver and identification of the in vivo phosphorylation sites.
1994 • 66 citations
Phosphorylation of the Drosophila Engrailed Protein at a Site Outside Its Homeodomain Enhances DNA Binding
1995 • 64 citations
Evaluation of the catalytic mechanism of recombinant human Csk (C-terminal Src kinase) using nucleotide analogs and viscosity effects.
1994 • 64 citations
Mutations at sites involved in Suc1 binding inactivate Cdc2.
1991 • 63 citations
A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites.
1993 • 62 citations
In vitro phosphorylation of caveolin-rich membrane domains: identification of an associated serine kinase activity as a casein kinase II-like enzyme.
1994 • 62 citations
Efficient autophosphorylation and phosphorylation of the beta-subunit by casein kinase-2 require the integrity of an acidic cluster 50 residues downstream from the phosphoacceptor site.
1994 • 59 citations
Casein Kinase II Associates with Egr-1 and Acts as a Negative Modulator of Its DNA Binding and Transcription Activities in NIH 3T3 Cells
1996 • 58 citations
A majority of casein kinase II ? subunit is tightly bound to intranuclear components but not to the ? subunit
1993 • 58 citations
Characterization of the in Vivo Phosphorylation Sites of the mRNA·Cap-binding Complex Proteins Eukaryotic Initiation Factor-4E and p20 in Saccharomyces cerevisiae
1995 • 57 citations
Molecular cloning of casein kinase II alpha subunit from Dictyostelium discoideum and its expression in the life cycle.
1992 • 56 citations
Association of casein kinase 2 with nuclear chromatin in relation to androgenic regulation of rat prostate.
1993 • 56 citations
Protein kinases and protooncogenes: biochemical regulators of the eukaryotic cell cycle
1991 • 56 citations
Phosphorylation of synthetic fragments of inhibitor‐2 of protein phosphatase‐1 by casein kinase‐1 and ‐2
1994 • 55 citations
Nucleoplasmin associates with and is phosphorylated by casein kinase ii
1995 • 55 citations
Regulation of casein kinase 2 by phosphorylation/dephosphorylation
1987 • 54 citations
Purification and characterization of maize seedling casein kinase IIB, a monomeric enzyme immunologically related to the α subunit of animal casein kinase‐2
1992 • 54 citations
Identification and Characterization of Protein Kinase CKII Isoforms in HeLa Cells
1995 • 53 citations
Structure of protein kinase CK2: Dimerization of the human β‐subunit
1996 • 52 citations
Casein kinase II and protein kinase C modulate hepatitis delta virus RNA replication but not empty viral particle assembly
1996 • 52 citations
Differential phosphorylations of Spi-B and Spi-1 transcription factors.
1996 • 51 citations
Chemical Features of the Protein Kinase CK2 Polyamine Binding Site,
1997 • 50 citations
Direct Identification of a Polyamine Binding Domain on the Regulatory Subunit of the Protein Kinase Casein Kinase 2 by Photoaffinity Labeling
1995 • 49 citations
Purification and tissue‐specific expression of casein kinase from the lactating guinea‐pig mammary gland
1985 • 49 citations
Epstein-Barr Virus SM Protein
1994 • 49 citations
Cloning and characterization of the casein kinase II .alpha. subunit gene from the lymphocyte-transforming intracellular protozoan parasite Theileria parva
1992 • 49 citations
Enhanced casein kinase II activity in COS-1 cells upon overexpression of either its catalytic or noncatalytic subunit
1991 • 48 citations
The identification of the phosphorylated 150/160-kDa proteins of sarcoplasmic reticulum, their kinase and their association with the ryanodine receptor
1996 • 48 citations
Casein Kinase II Is Required for Efficient Transcription by RNA Polymerase III
1996 • 48 citations
The Role of Controlled Proteolysis in Cell‐Cycle Regulation
1996 • 48 citations
A simple procedure for the purification of rat liver phosvitin kinase
1970 • 47 citations
Genetic Dissection of Intersubunit Contacts Within Human Protein Kinase CK2
1995 • 46 citations
Casein Kinase II of Saccharomyces cerevisiae Contains Two Distinct Regulatory Subunits, β and β′
1994 • 44 citations
Adenine Nucleotides in Cellular Energy Transfer and Signal Transduction
1992 • 44 citations
Phosphorylation of HIV-1 Rev Protein: Implication of Protein Kinase CK2 and Pro-Directed Kinases
1996 • 44 citations
C-Terminal phosphorylation of human respiratory syncytial virus P protein occurs mainly at serine residue 232
1995 • 43 citations
Protein Phosphorylation
1993 • 43 citations
Interaction of the β Subunit of Casein Kinase II with the Ribosomal Protein L5
1996 • 42 citations
Protein-tyrosine phosphatase activity of CD45 is activated by sequential phosphorylation by two kinases.
1994 • 40 citations
Isolation of an Arabidopsis thaliana casein kinase II ? subunit by complementation in Saccharomyces cerevisiae
1994 • 39 citations
Plant Calreticulin Is Specifically and Efficiently Phosphorylated by Protein Kinase CK2
1996 • 38 citations
Human cytomegalovirus pp65 lower matrix phosphoprotein harbours two transplantable nuclear localization signals
1996 • 37 citations
Expression of Casein Kinase 2 during Mouse Embryogenesis
1994 • 37 citations
Casein kinase II mediates multiple phosphorylation of Saccharomyces cerevisiae eIF-2 alpha (encoded by SUI2), which is required for optimal eIF-2 function in S. cerevisiae.
1994 • 37 citations
Identification and cDNA cloning of a Xenopus nucleolar phosphoprotein, xNopp180, that is the homolog of the rat nucleolar protein Nopp140
1995 • 37 citations
Evidence for Phosphorylation of CTP:Phosphocholine Cytidylyltransferase by Multiple Proline-directed Protein Kinases
1996 • 37 citations
The in vitro phosphorylation of the native rat incisor dentin phosphophoryns.
1992 • 37 citations
Characterization of the .alpha. and .beta. subunits of casein kinase 2 by far-UV CD spectroscopy
1992 • 37 citations
Interaction Sites between Catalytic and Regulatory Subunits in Human Protein Kinase CK2 Holoenzymes as Indicated by Chemical Cross-Linking and Immunological Investigations
1996 • 34 citations
Mapping the residues of protein kinase CK2 α subunit responsible for responsiveness to polyanionic inhibitors
1996 • 33 citations
Mapping the Residues of Protein Kinase CK2 Implicated in Substrate Recognition: Mutagenesis of Conserved Basic Residues in the α-Subunit
1995 • 33 citations
Altered protein kinase activities of lymphoid cells transformed by Abelson and Moloney leukemia viruses
1986 • 33 citations
Induction and regulation of casein kinase II during B lymphocyte activation.
1991 • 32 citations
Activation of Dictyostelium myosin light chain kinase A by phosphorylation of Thr166.
1996 • 32 citations
Differential CKII Activities in Human Colorectal Mucosa, Adenomas and Carcinomas
1991 • 30 citations
Cloning, Expression and Properties of the α′ Subunit of Casein Kinase 2 from Zebrafish (Danio Rerio)
1996 • 30 citations
Benzimidazole nucleoside analogues as inhibitors of plant (maize seedling) casein kinases
1991 • 30 citations
Effects of Autophosphorylation on Casein Kinase II Activity: Evidence from Mutations in the .beta. Subunit
1994 • 27 citations
Phosphorylation and Activation of Protein Kinase Ck2 by p34cdc2 are Independent Events
1995 • 27 citations
Cyclic adenosine 3':5'-monophosphate-dependent and -independent protein kinases in human leukemic cells.
1983 • 26 citations
Biochemistry of Cell Membranes
1995 • 26 citations
Casein kinase 2 activity increases in the prereplicative phase of liver regeneration
1988 • 26 citations
Evidence for a phosphorylation site in cytomegalovirus glycoprotein gB
1996 • 24 citations
Activity of the E75E76 mutant of the α subunit of casein kinase II from Xenopus laevis
1994 • 23 citations
The autophosphorylation and p34cdc2 phosphorylation sites of casein kinase-2 β-subunit are not essential for reconstituting the fully-active heterotetrameric holoenzyme
1993 • 23 citations
Growth‐related protein kinases
1990 • 22 citations
Tyrosine phosphorylation of a M(r) 38,000 A/B-type hnRNP protein selectively modulates its RNA binding.
1994 • 22 citations
Phosphorylation and Activation of Protein Kinase Ck2 by p34cdc2 are Independent Events
1995 • 20 citations
Polyamines as Negative Regulators of Casein Kinase-2: The Phosphorylation of Calmodulin Triggered by Polylysine and by the α[66-86] Peptide Is Prevented by Spermine
1993 • 20 citations
Phosphorylation of NM23/Nucleoside Diphosphate Kinase by Casein Kinase 2 in Vitro
1994 • 19 citations
Site‐Directed Mutagenesis and Structure/Function Studies of Casein Kinase II Correlate Stimulation of Activity by the β Subunit with Changes in Conformation and ATP/GTP Utilization
1995 • 18 citations
Casein kinase II β-subunit inhibits the activity of the catalytic α-subunit in the absence of salt
1993 • 17 citations
In Vitro Phosphorylation of the Polyomavirus Major Capsid Protein VP1 on Serine 66 by Casein Kinase II
1995 • 17 citations
Site-Directed Mutagenesis and Structure/Function Studies of Casein Kinase II Correlate Stimulation of Activity by the beta Subunit with Changes in Conformation and ATP/GTP Utilization
1995 • 16 citations
Fragmin, a Microfilament Regulatory Protein from Physarum polycephalum, Is Phosphorylated by Casein Kinase II-Type Enzymes
1996 • 16 citations
Purification and Characterization of 100-kDa Glycyrrhizin (GL)-Binding Protein (gp100) as an Effective Phosphate Acceptor for CK-II and the Effect of GL on the Phosphorylation of gp100 by CK-II in Vitro
1994 • 15 citations
ABF1 Ser-720 Is a Predominant Phosphorylation Site for Casein Kinase II of Saccharomyces cerevisiae
1995 • 14 citations
Molecular Cloning and Characterization of a Novel Casein Kinase II Substrate, HASPP28, from Rat Brain
1996 • 14 citations
Substrate recognition by casein kinase‐II: The role of histidine‐160
1994 • 14 citations
Oligomeric Casein Kinase II Isoforms Are Expressed in Bovine Tissues and Adrenocortical Cells in Culture
1994 • 13 citations
Growth-related enzyme activities in crypt compartments during rat colon carcinogenesis.
1990 • 12 citations
Changes in the Activity of Nuclear Protein Kinase CK2 During Rat Liver Regeneration
1996 • 12 citations
Nuclear transport and phosphorylation of the RNA binding Xenopus zinc finger protein XFG 5-1
1992 • 12 citations
Casein kinase-2 and cell signaling
1995 • 11 citations
Purification and Phosphorylation of a Mr 25, 000 Protein, an Effective Phosphate Acceptor for Casein Kinase II and Protein Kinase C, Detected in the Cytosolic Fraction of Xenopus laevis Oocytes1
1995 • 10 citations
Subcellular Distribution and Phosphorylation of the Nuclear Localization Signal Binding Protein, NBP60
1996 • 10 citations
A 96-KDa Glycyrrhizin-Binding Protein (gp96) from Soybeans Acts as a Substrate for Case in Kinase II, and Is Highly Realted to Lipoxygenase31
1995 • 9 citations
Phosphorylation of acidic ribosomal proteins by ribosome-associated protein kinases of Saccharomyces cerevisiae and Schizosaccharomyces pombe.
1993 • 9 citations
Casein Kinase II Site of Human Centromere Protein B (CENP-B) is Phosphorylatedin Vitro
1992 • 7 citations
Changes in protein kinase activities in lamb adrenals at late gestation and early postnatal stages
1987 • 7 citations
Identification of a cryptic protein kinase CK2 phosphorylation site in human complement protease C1r, and its use to probe intramolecular interaction
1996 • 6 citations
Proteins of theXenopus laevis zinc finger multigene family as targets for CK II phosphorylation
1995 • 5 citations
Casein Kinases: An Atypical Class of Ubiquitous and Pleiotropic Protein Kinases
1992 • 5 citations
Insert Regions in Domain X of the Casein Kinase II Catalytic Subunit
1995 • 2 citations
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