Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

1991 • 5,267 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor

1996 • 1,946 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

Slow-cooling protocols for crystallographic refinement by simulated annealing

1990 • 530 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

1996 • 479 citations

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain

1998 • 477 citations

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.

1989 • 447 citations

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.

1991 • 415 citations

Structural basis of inhibitor selectivity in MAP kinases

1998 • 408 citations

T cell antigen receptor signal transduction

1997 • 390 citations

A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket

1997 • 387 citations

Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.

1995 • 355 citations

Fidelity of T Cell Activation Through Multistep T Cell Receptor ζ Phosphorylation

1998 • 338 citations

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.

1996 • 324 citations

Different Susceptibility of Protein Kinases to Staurosporine Inhibition

1995 • 284 citations

The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase

1997 • 274 citations

DIFFERENTIAL SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1997 • 273 citations

Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells.

1993 • 271 citations

Cubanecarboxylic Acids. Crystal Engineering Considerations and the Role of C−H···O Hydrogen Bonds in Determining O−H···O Networks

1999 • 251 citations

The 2.35 å crystal structure of the inactivated form of chicken src: a dynamic molecule with multiple regulatory interactions

1997 • 251 citations

Adaptors and Molecular Scaffolds in Immune Cell Signaling

1999 • 222 citations

Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70.

1994 • 215 citations

ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity.

1995 • 196 citations

Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70

1995 • 183 citations

Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45).

1990 • 173 citations

Binding of ZAP-70 to Phosphorylated T-Cell Receptor ζ and η Enhances Its Autophosphorylation and Generates Specific Binding Sites for SH2 Domain-Containing Proteins

1995 • 154 citations

Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential

1997 • 150 citations

Lymphocyte Activation in Health and Disease

1997 • 148 citations

A tyrosine-phosphorylated 70-kDa protein binds a photoaffinity analogue of ATP and associates with both the zeta chain and CD3 components of the activated T cell antigen receptor.

1992 • 146 citations

Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine 1 1Edited by I. A. Wilson

1999 • 138 citations

The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation.

1993 • 134 citations

A Zn2+ Ion Links the Cytoplasmic Tail of CD4 and the N-terminal Region of Lck

1998 • 97 citations

Zinc Is Essential for Binding of p56 to CD4 and CD8α

1998 • 90 citations

Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells

1997 • 84 citations

Association of CD8 with p56lck is required for early T cell signalling events.

1991 • 79 citations

Protein tyrosine kinase inhibitors in cancer treatment

1997 • 75 citations

Tyrosine kinase inhibitors in cancer treatment (Part II)

1998 • 65 citations

Structures of staurosporine bound to CDK2 and cAPK – new tools for structure-based design of protein kinase inhibitors

1997 • 64 citations

The p56^lck SH2 domain mediates recruitment of CD8/p56^lck to the activated T cell receptor/CD3/ζ complex

1996 • 62 citations

Purification and initial characterization of the lymphocyte-specific protein-tyrosyl kinase p56lck from a baculovirus expression system.

1992 • 60 citations

Peripheral T cells in mice lacking p56lck do not express significant antiviral effector functions.

1993 • 46 citations

The SH2 Domain is Required for Stable Phosphorylation of p56^1ck at Tyrosine 505, the Negative Regulatory Site

1993 • 44 citations

Functional analysis of the SH2 and SH3 domains of the lck tyrosine protein kinase.

1992 • 41 citations

Detection of a Physical and Functional Interaction between Csk and Lck Which Involves the SH2 Domain of Csk and Is Mediated by Autophosphorylation of Lck on Tyrosine 394

1996 • 36 citations

Requirement for kinase activity of CD4-associated p56lck in antibody-triggered T cell signal transduction.

1994 • 34 citations

p56lck Signals for Regulating Thymocyte Development Can Be Distinguished by Their Dependency on Rho Function

1998 • 33 citations

Up-regulation of c-myc induces the gene expression of the murine homologues of p34cdc2 and cyclin-dependent kinase-2 in T lymphocytes.

1994 • 32 citations

The protein tyrosine kinase p56lck regulates thymocyte development independently of its interaction with CD4 and CD8 coreceptors [corrected]

1993 • 31 citations

Genetic Evidence of a Role for Lck in T-Cell Receptor Function Independent or Downstream of ZAP-70/Syk Protein Tyrosine Kinases

1998 • 29 citations

Mechanism of activation for Zap-70 catalytic activity.

1996 • 29 citations

Complementary DNA Cloning and Kinetic Characterization of a Novel Intracellular Serine Proteinase Inhibitor: Mechanism of Action with Trypsin and Factor Xa as Model Proteinases

1994 • 26 citations

The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site.

1993 • 25 citations

Tyr394 and Tyr505 are Autophosphorylated in Recombinant Lck Protein‐tyrosine Kinase Expressed in Escherichia coli

1994 • 20 citations