Vaccination with novel combinations of anti-HER2/neu cytokines fusion proteins and soluble protein antigen elicits a protective immune response against HER2/neu expressing tumors

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Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

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[32] Production and properties of chimeric antibody molecules

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Recombinant Anti-Human HER2/neuIgG3-(GM-CSF) Fusion Protein Retains Antigen Specificity and Cytokine Function and Demonstrates Antitumor Activity

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A Single-Chain IL-12 IgG3 Antibody Fusion Protein Retains Antibody Specificity and IL-12 Bioactivity and Demonstrates Antitumor Activity

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Interleukin 12 potentiates the curative effect of a vaccine based on interleukin 2-transduced tumor cells.

1996 • 77 citations

Hypoxia-mediated apoptosis from angiogenesis inhibition underlies tumor control by recombinant interleukin 12.

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Bi-functional cytokine fusion proteins for gene therapy and antibody-targeted treatment of cancer

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Protein vaccination with the HER2/neu extracellular domain plus anti-HER2/neu antibody–cytokine fusion proteins induces a protective anti-HER2/neu immune response in mice

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Tumor-targeted IL-2 amplifies T cell-mediated immune response induced by gene therapy with single-chain IL-12

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Combined IL-12 and GM-CSF gene therapy for murine hepatocellular carcinoma

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A recombinant IgG3-(IL-2) fusion protein for the treatment of human HER2/neu expressing tumors

2001 • 43 citations

Anti-tumor activity of interleukin-2-producing tumor cells and recombinant interleukin 12 against mouse glioma cells located in the central nervous system

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A B7.1-Antibody Fusion Protein Retains Antibody Specificity and Ability to Activate Via the T Cell Costimulatory Pathway

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The IL‐2 mediated amplification of cellular cytotoxicity

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An IgG3-IL2 fusion protein activates complement, binds FcγRI, generates LAK activity and shows enhanced binding to the high affinity IL-2R

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Antibody–Cytokine Fusion Proteins for the Therapy of Cancer

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Characterization of Lymphokine-Activated Killing by Human Peripheral Blood Mononuclear Cells Stimulated with Interleukin 2 (IL-2) Analogs Specific for the Intermediate Affinity IL-2 Receptor

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Anti-immunoglobulin antibodies

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Anti-immunoglobulin antibodies

2006 • 1 citations

Deleted Work

1955 • 0 citations