HER-2/neu Amplification in Benign Breast Disease and the Risk of Subsequent Breast Cancer

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Risk Factors for Breast Cancer in Women with Proliferative Breast Disease

1985 • 1,817 citations

c-erbB-2 Expression and Response to Adjuvant Therapy in Women with Node-Positive Early Breast Cancer

1994 • 981 citations

Laser Capture Microdissection: Molecular Analysis of Tissue

1997 • 890 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

Sensitivity of HER-2/neu antibodies in archival tissue samples: potential source of error in immunohistochemical studies of oncogene expression.

1994 • 495 citations

A Prospective Study of Benign Breast Disease and the Risk of Breast Cancer

1992 • 491 citations

Her-2/neu expression in node-negative breast cancer: direct tissue quantitation by computerized image analysis and association of overexpression with increased risk of recurrent disease.

1993 • 432 citations

Overexpression of HER-2/neu and its relationship with other prognostic factors change during the progression of in situ to invasive breast cancer

1992 • 415 citations

Interobserver Reproducibility in the Diagnosis of Ductal Proliferative Breast Lesions Using Standardized Criteria

1992 • 414 citations

Borderline Epithelial Lesions of the Breast

1991 • 411 citations

A family of AP-2 proteins regulates c-erbB-2 expression in mammary carcinoma.

1996 • 228 citations

The developmentally regulated transcription factor AP-2 is involved in c-erbB-2 overexpression in human mammary carcinoma.

1995 • 228 citations

Association of multiple copies of the c-erbB-2 oncogene with spread of breast cancer.

1987 • 214 citations

Association of atypical characteristics of benign breast lesions with subsequent risk of breast cancer

1972 • 210 citations

Detection of amplified oncogenes by differential polymerase chain reaction.

1989 • 209 citations

The HER2 (c-erbB-2) oncogene is frequently amplified in in situ carcinomas of the breast.

1992 • 196 citations

c-erbB-2 expression in benign and malignant breast disease

1988 • 190 citations

correlation between histologic grade of malignancy and copy number of c-erbb-2 gene in breast carcinoma. A retrospective analysis of 176 cases

1990 • 152 citations

Prognostic significance of benign proliferative breast disease

1993 • 152 citations

Quantitation of HER-2/neu and c-myc gene amplification in breast carcinoma using fluorescence in situ hybridization.

1997 • 133 citations

p53 and c-erbB-2 Protein Expression in Breast Carcinomas: An Immunohistochemical Study Including Correlations with Receptor Status, Proliferation Markers, and Clinical Stage in Human Breast Cancer

1992 • 126 citations

ERBB-2 (HER2/neu) gene copy number, p185HER-2 overexpression, and intratumor heterogeneity in human breast cancer.

1995 • 122 citations

Immunohistochemical evaluation of c-erbB-2 oncogene expression in ductal carcinoma in situ and atypical ductal hyperplasia of the breast.

1990 • 122 citations

Detection of allelic imbalance indicates that a proportion of mammary hyperplasia of usual type are clonal, neoplastic proliferations.

1996 • 120 citations

Molecular genetic studies of early breast cancer evolution

1994 • 120 citations

Analysis of c-erbB-2 expression in breast carcinomas with clinical follow-up.

1989 • 115 citations

Correlation of HER-2/neu Amplification With Expression and With Other Prognostic Factors in 1103 Breast Cancers

1992 • 109 citations

Immunohistochemical Detection of c-erbB-2 and p53 in Benign Breast Disease and Breast Cancer Risk

1998 • 108 citations

NCL‐CB11, a new monoclonal antibody recognizing the internal domain of the c‐erbB‐2 oncogene protein effective for use on formalin‐fixed, paraffin‐embedded tissue

1990 • 108 citations

Quantitative estimation of epidermal growth factor receptor and c-erbB-2 in human breast cancer.

1996 • 84 citations

p53 mutations in benign breast tissue.

1995 • 78 citations

C-erbB2 mRNA expression in human breast tumours: comparison with c-erbB2 DNA amplification and correlation with prognosis

1990 • 77 citations

Amplification of c-myc but not of c-erbB-2 is associated with high proliferative capacity in breast cancer.

1993 • 73 citations

Diagnosis of Duchenne and Becker Muscular Dystrophies by Polymerase Chain Reaction

1992 • 71 citations

Test reliability is critically important to molecular epidemiology: an example from studies of human papillomavirus infection and cervical neoplasia.

1994 • 60 citations

Apocrine adenosis: a precursor of aggressive breast cancer?

1995 • 58 citations

Breast cancer cell kinetics: immunocytochemical determination of growth fractions by monoclonal antibody Ki-67 and correlation with flow cytometric S-phase and with some features of tumor aggressiveness.

1991 • 52 citations

Histologic Sampling of Grossly Benign Breast Biopsies

1989 • 50 citations

Microsatellite alterations indicating monoclonality in atypical hyperplasias associated with breast cancer

1997 • 43 citations

Biomarkers in early breast neoplasia

1993 • 42 citations

Amplification units and translocation at chromosome 17q and c- erb B-2 overexpression in the pathogenesis of breast cancer

1997 • 40 citations

Detection of monoclonal microsatellite alterations in atypical breast hyperplasia.

1996 • 37 citations

Benign breast disease: absence of genetic alterations at several loci implicated in breast cancer malignancy.

1995 • 34 citations

A new cis element is involved in the HER2 gene overexpression in human breast cancer cells.

1999 • 28 citations

In situ distribution of oncogene products and growth factor receptors in breast carcinoma: c-erbB-2 oncoprotein, EGFr, and PDGFr-β-subunit

1990 • 28 citations

C-erbB-2 Oncogene Product Expression Depends on Tumour Type and is Related to Oestrogen Receptor and Lymph Node Status in Human Breast Carcinoma

1993 • 21 citations

MECHANISMS OF DEREGULATED HER2/NEU EXPRESSION IN BREAST-CANCER CELL-LINES

1994 • 19 citations

Detection of HER-2 oncogene amplification in breast cancer by differential polymerase chain reaction from single cryosections

1993 • 16 citations

Immunohistochemical studies on c-erbB-2 oncoprotein expression in paraffin embedded tissues in invasive and non-invasive human breast lesions.

1994 • 14 citations

Surrogate endpoints in chemoprevention of breast cancer: Guidelines for evaluation of new biomarkers

1993 • 10 citations

Clonal analysis by PCR and RFLP in breast cancer and precancerous lesions. Preliminary data.

1996 • 6 citations