Protein vaccination with the HER2/neu extracellular domain plus anti-HER2/neu antibody–cytokine fusion proteins induces a protective anti-HER2/neu immune response in mice

Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer.

1996 • 1,393 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

Biology of HER2 and Its Importance in Breast Cancer

2001 • 710 citations

Granulocyte/macrophage colony-stimulating factor and interleukin 1 mediate the maturation of murine epidermal Langerhans cells into potent immunostimulatory dendritic cells.

1988 • 565 citations

Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells

2000 • 544 citations

DNA Vaccination Against Rat Her-2/Neu p185 More Effectively Inhibits Carcinogenesis Than Transplantable Carcinomas in Transgenic BALB/c Mice

2000 • 354 citations

Generation of immunity to the HER-2/neu oncogenic protein in patients with breast and ovarian cancer using a peptide-based vaccine.

1999 • 339 citations

Granulocyte-macrophage colony-stimulating factor augments the primary antibody response by enhancing the function of antigen-presenting cells.

1987 • 299 citations

Granulocyte-macrophage colony-stimulating factor activates macrophages derived from bone marrow cultures to synthesis of MHC class II molecules and to augmented antigen presentation function.

1988 • 227 citations

IL-10 stimulates monocyte Fc gamma R surface expression and cytotoxic activity. Distinct regulation of antibody-dependent cellular cytotoxicity by IFN-gamma, IL-4, and IL-10.

1992 • 220 citations

Her-2/ neu and Breast Cancer

2001 • 217 citations

Mechanistic aspects of the opposing effects of monoclonal antibodies to the ERBB2 receptor on tumor growth.

1991 • 208 citations

Peptide-based, but not whole protein, vaccines elicit immunity to HER-2/neu, oncogenic self-protein.

1996 • 185 citations

IL-12 Is Required for Antibody-Mediated Protective Immunity Against Blood-StagePlasmodium chabaudiAS Malaria Infection in Mice

2002 • 177 citations

Peptides derived from a wild-type murine proto-oncogene c-erbB-2/HER2/neu can induce CTL and tumor suppression in syngeneic hosts.

1997 • 157 citations

Targeting of renal cell carcinoma with iodine-131-labeled chimeric monoclonal antibody G250.

1997 • 157 citations

The effect of IFN-gamma and colony-stimulating factors on the expression of neutrophil cell membrane receptors.

1989 • 147 citations

Identification of the mouse IgG3 receptor: implications for antibody effector function at the interface between innate and adaptive immunity.

1998 • 130 citations

IFN-gamma induces expression of Fc gamma RIII (CD16) on human eosinophils.

1992 • 114 citations

GM-CSF-based cellular vaccines: a review of the clinical experience

2002 • 107 citations

Effects of gamma-interferon on human neutrophils: protection from deterioration on storage

1992 • 105 citations

Circulating HER-2/erbB-2/c-neu (HER-2) extracellular domain as a prognostic factor in patients with metastatic breast cancer: Cancer and Leukemia Group B Study 8662.

2001 • 98 citations

Cutting Edge: Identification of the Mouse IgG3 Receptor: Implications for Antibody Effector Function at the Interface Between Innate and Adaptive Immunity

1998 • 97 citations

Cytokines in cancer therapy

2000 • 93 citations

Amplification of IL-2-driven T cell proliferation by recombinant human IL-3 and granulocyte-macrophage colony-stimulating factor.

1988 • 90 citations

Vaccination with the extracellular domain of p185 neu prevents mammary tumor development in neu transgenic mice

1999 • 84 citations

Recombinant Anti-Human HER2/neuIgG3-(GM-CSF) Fusion Protein Retains Antigen Specificity and Cytokine Function and Demonstrates Antitumor Activity

2000 • 84 citations

Interleukin‐12 acts as an adjuvant for humoral immunity through interferon‐γ‐dependent and ‐independent mechanisms

1997 • 81 citations

HER-2/neu Oncogenic Protein: Issues in Vaccine Development

1998 • 80 citations

A Single-Chain IL-12 IgG3 Antibody Fusion Protein Retains Antibody Specificity and IL-12 Bioactivity and Demonstrates Antitumor Activity

1999 • 77 citations

Identification of Epitope Regions Recognized by Tumor Inhibitory and Stimulatory Anti-ErbB-2 Monoclonal Antibodies: Implications for Vaccine Design

2001 • 77 citations

Granulocyte-macrophage colony-stimulating factor stimulates human monocyte accessory cell function.

1990 • 75 citations

Interleukin-12 as an Adjuvant for Cancer Immunotherapy

1999 • 70 citations

DNA vaccination against neu reduces breast cancer incidence and metastasis in mice

2001 • 70 citations

Prevention of spontaneous neu-expressing mammary tumor development in mice transgenic for rat proto-neu by DNA vaccination

2001 • 67 citations

Vaccination with Her-2/neu DNA or protein subunits protects against growth of a Her-2/neu-expressing murine tumor

2001 • 55 citations

Development of a cancer vaccine: peptides, proteins, and DNA

2000 • 50 citations

In vivo properties of three human HER2/neu-expressing murine cell lines in immunocompetent mice.

1999 • 49 citations

In vivo properties of an IgG3-IL-2 fusion protein. A general strategy for immune potentiation.

1996 • 48 citations

Human basophils selectively express the FcγRII (CDw32) subtype of IgG receptor

1989 • 44 citations

IgG2a induced by interleukin (IL) 12-producing tumor cell vaccines but not IgG1 induced by IL-4 vaccine is associated with the eradication of experimental metastases.

1998 • 44 citations

Direct Activation of Murine Peritoneal Macrophages for Nitric Oxide Production and Tumor Cell Killing by Interferon-γ

1995 • 43 citations

A recombinant IgG3-(IL-2) fusion protein for the treatment of human HER2/neu expressing tumors

2001 • 43 citations

Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Advanced Malignancy: A Phase Ib Trial

1990 • 41 citations

Successful Treatment With a Chimeric Anti-CD20 Monoclonal Antibody (IDEC-C2B8, Rituximab) for a Patient With Relapsed Mantle Cell Lymphoma Who Developed a Human Anti-Chimeric Antibody

2001 • 40 citations

Cancer vaccines targeting the HER2/ oncogenic protein

2001 • 38 citations

Interferon gamma augments Lym-1-dependent, granulocyte-mediated tumor cell lysis

1990 • 34 citations

Clinical trials of HER-2/neu-specific vaccines.

2000 • 29 citations

Differential effects of interferon-γ and glucocorticoids on FcγR gene expression in murine macrophages

1993 • 26 citations

IL-2 linked to a peptide from influenza hemagglutinin enhances T cell activation by affecting the antigen-presentation function of bone marrow-derived dendritic cells

2001 • 23 citations

Differential Modulation of Surface Antigens on Human Macrophages by IFN-Gamma and GM-CSF: Effect on Susceptibility to LAK Lysis

1991 • 17 citations

Clinical Translation of Peptide-Based Vaccine Trials: The HER-2/neu Model

2001 • 15 citations

Humoral and cellular responses raised against the human HER2 oncoprotein are cross-reactive with the homologous product of the neu proto-oncogene, but do not protect rats against B104 tumors expressing mutated neu

1996 • 10 citations

Monocyte-mediated lysis of acute myeloid leukemia cells in the presence of the bispecific antibody 251 x 22 (anti-CD33 x anti-CD64).

1995 • 9 citations