Bi-functional cytokine fusion proteins for gene therapy and antibody-targeted treatment of cancer

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

1995 • 491 citations

Paracrine Cytokine Adjuvants in Cancer Immunotherapy

1995 • 373 citations

Structure-activity relationships of chemokines

1995 • 367 citations

Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells.

1992 • 333 citations

IL-12 receptor. II. Distribution and regulation of receptor expression.

1992 • 298 citations

Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2.

1992 • 284 citations

Effects of IL-12 on the generation of cytotoxic activity in human CD8+ T lymphocytes.

1993 • 214 citations

Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivo

1997 • 146 citations

Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18.

1998 • 124 citations

Pharmacokinetics of human granulocyte-macrophage colony-stimulating factor using a sensitive immunoassay

1988 • 124 citations

Synergistic effects of IL-7 and IL-12 on human T cell activation.

1995 • 110 citations

Biological activity and in vivo clearance of anti-tumor antibody/cytokine fusion proteins

1993 • 95 citations

Elimination of established murine colon carcinoma metastases by antibody-interleukin 2 fusion protein therapy.

1997 • 94 citations

Antibody-IL-12 Fusion Proteins Are Effective in SCID Mouse Models of Prostate and Colon Carcinoma Metastases

1998 • 93 citations

High level expression and secretion of Fc-X fusion proteins in mammalian cells

1998 • 80 citations

A Single-Chain IL-12 IgG3 Antibody Fusion Protein Retains Antibody Specificity and IL-12 Bioactivity and Demonstrates Antitumor Activity

1999 • 77 citations

Phenotypically diverse mouse thymic stromal cell lines which induce proliferation and differentiation of hematopoietic cells

1993 • 74 citations

Cytokine Gene Therapy of Cancer Using Interleukin‐12: Murine and Clinical Trials

1996 • 72 citations

Activation of human effector cells by a tumor reactive recombinant anti-ganglioside GD2 interleukin-2 fusion protein (ch14.18-IL2).

1996 • 68 citations

Hematopoietic effects of a granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein

1991 • 44 citations

Adjuvant-independent enhanced immune responses to recombinant herpes simplex virus type 1 glycoprotein D by fusion with biologically active interleukin-2

1993 • 43 citations

Superiority of interleukin-12-transduced murine lung cancer cells to GM-CSF or B7-1 (CD80) transfectants for therapeutic antitumor immunity in syngeneic immunocompetent mice.

1998 • 28 citations

Antimetastatic vaccination against Lewis lung carcinoma with autologous tumor cells modified to express murine Interleukin 12

1998 • 19 citations

The fusion protein MEN 11303 (granulocyte-macrophage colony stimulating factor/erythropoietin) acts as a potent inducer of erythropoiesis

2000 • 10 citations