Isolated perfusion of the kidney with tumor necrosis factor for localized renal-cell carcinoma

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Cachectin and tumour necrosis factor as two sides of the same biological coin

1986 • 1,659 citations

Cancer statistics, 1994

1994 • 1,345 citations

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

1989 • 1,096 citations

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

1986 • 1,079 citations

Experience with the Use of High-Dose Interleukin-2 in the Treatment of 652 Cancer Patients

1989 • 1,003 citations

High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma.

1992 • 730 citations

A phase I trial of intravenously-administered recombinant tumor necrosis factor-alpha in cancer patients.

1988 • 220 citations

Prevalence of Microscopic lesions in Grossly Normal Renal Parenchyma from Patients with von Hippel-Lindau Disease, Sporadic Renal Cell Carcinoma and No Renal Disease: Clinical Implications

1995 • 185 citations

In transit metastases of malignant melanoma treated by high dose rTNFα in combination with interferon‐γ and melphalan in isolation perfusion

1992 • 124 citations

Synergistic enhancement by tumor necrosis factor of in vitro cytotoxicity from chemotherapeutic drugs targeted at DNA topoisomerase II.

1987 • 116 citations

Regional isolation perfusion in melanoma of the limbs; accomplishments, unsolved problems, future.

1988 • 115 citations

Cytokine levels and systemic toxicity in patients undergoing isolated limb perfusion with high-dose tumor necrosis factor, interferon gamma, and melphalan.

1995 • 103 citations

Phase I study of recombinant human tumor necrosis factor ? in advanced malignant disease

1989 • 96 citations

Original Articles

1995 • 83 citations

Original Articles: Kidney Cancer: Parenchymal Sparing Surgery in Patients With Hereditary Renal Cell Carcinoma

1995 • 79 citations

Long-Term Followup after Nephron Sparing Surgery for Renal Cell Carcinoma in Von Hippel-Lindau Disease

1992 • 78 citations

RENAL-SPARING SURGERY FOR RENAL CELL CARCINOMA

1993 • 72 citations

Surgical Treatment of Localized Renal Cell Carcinoma in Von Hippel-Lindau’s Disease

1988 • 58 citations

Conservative Renal Surgery for Renal Cell Carcinoma in Von Hippel-Lindau’s Disease

1993 • 47 citations

A Phase II Study of Recombinant Tumor Necrosis Factor in Renal Cell Carcinoma

1992 • 41 citations

Intralesional recombinant tumor necrosis factor-alpha for AIDS-associated Kaposi's sarcoma: a randomized, double-blind trial.

1989 • 33 citations

Phase I study of 24-hour continuous intravenous infusion of recombinant human tumor necrosis factor.

1988 • 30 citations

Hyperthermia: effects on renal ischemic/reperfusion injury in the rat.

1990 • 30 citations

Antiproliferative and cytotoxic effects of single and combined treatment with tumor necrosis factor alpha and/or alpha interferon on a human renal cell carcinoma xenotransplanted into nu/nu mice: cell kinetic studies.

1990 • 27 citations

Use of tumor necrosis factor in isolated hepatic perfusion.

1994 • 26 citations

Overcoming TNF-αand Drug Resistance of Human Renal Cell Carcinoma Cells by Treatment with Pentoxifylline in Combination with TNF-αor Drugs: The Role of TNF-αmRNA Downregulation in Tumor Cell Sensitization

1994 • 25 citations

Differential sensitivity of renal cell carcinoma xenografts towards therapy with interferon-alpha, interferon-gamma, tumor necrosis factor and their combinations

1991 • 19 citations

Enhanced Anti-Tumor Effects of Recombinant Human Tumor Necrosis Factor Plus VP-16 On Metastatic Renal Cell Carcinoma in a Xenograft Model

1989 • 17 citations

In Vivo Antiproliferative Effects of Gamma-Interferon and Tumor Necrosis Factor Alpha in a Rat Renal Cell Carcinoma Model System

1990 • 14 citations

Sensitivity of Human Renal Cell Carcinoma Lines to TNF, Adriamycin, and Combination: Role of TNF mRNA Induction in Overcoming Resistance

1993 • 13 citations

The Current Use of Interferons, Interleukin-2 and Tumor Necrosis Factor in Renal Cell Cancer

1991 • 11 citations

Effect of Tumor Necrosis Factor and Interferon Gamma on Human Renal Carcinoma Cell Line Growth

1989 • 11 citations

Enhanced in vivo cytotoxicity of recombinant human tumor necrosis factor with etoposide in human renal cell carcinoma

1990 • 11 citations

In vitro antiproliferative efficacy of Interferon-alpha,-gamma and Tumor Necrosis Factor on two human renal tumor xenografts

1988 • 9 citations

Effect of alpha‐ and gamma‐Interferon and tumor necrosis factor on colony formation of two human renal tumor xenografts in vitro

1988 • 8 citations

Treatment with tumor necrosis factor alpha and interferon alpha of a human kidney cancer xenograft in nude mice: evidence for an anticachectic effect of interferon alpha.

1994 • 6 citations

Combined effects of tumor necrosis factor alpha and radiation in the treatment of renal cell carcinoma grown as radia spheroids.

1990 • 6 citations

Studies on in vitro mechanisms of anti-tumor activity of the tumor necrosis factor .ALPHA. against human renal carcinoma cell line (KU-2).

1989 • 3 citations

STUDIES ON ANTI-TUMOR ACTIVITY OF TUMOR NECROSIS FACTOR ^|^alpha; AGAINST HUMAN RENAL CELL CARCINOMA CELLS HETEROTRANSPLANTED INTO NUDE MICE

1991 • 2 citations

[In vivo anti-tumour efficacy of tumour necrosis factor and interferon- alpha, -gamma on human renal cell carcinoma heterotransplanted in nude mice].

1990 • 2 citations

The Effect of Tumor Necrosis Factor Alpha on a Human Renal Cell Carcinoma Xenotransplanted into Nude Mice: Comparison of Intravenous and Intraperitoneal Injection

1995 • 2 citations

Combined Effect of Tumor Necrosis Factor α and Anticancer Chemotherapeutic Agents against Human Renal Carcinoma Cell Lines

1991 • 2 citations

[Combination therapy with natural type human tumor necrosis factor (MHR-24) and human lymphoblastoid interferon-alpha (MOR-22) against renal cell carcinoma--a multiclinic cooperative, early phase II study. Subcommittee on Urogenital Malignancy, Committee on MHR-24 against Tumors].

1992 • 2 citations

Treatment of a Human Renal Cell Carcinoma in Nude Mice with Recombinant Human Tumor Necrosis Factor Alpha and Etoposide

1993 • 1 citations

STUDIES ON IN VITRO ANTI-TUMOR ACTIVITY OF TUMOR NECROSIS FACTOR ^|^alpha; AGAINST HUMAN RENAL CARCINOMA CELL LINE (KU-2)

1991 • 1 citations