Endothelial Cells Stimulate T Cell NFAT Nuclear Translocation in the Presence of Cyclosporin A: Involvement of the wnt/Glycogen Synthase Kinase-3β Pathway

A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

The Wnt/Ca2+ pathway

2000 • 843 citations

Dishevelled Activates JNK and Discriminates between JNK Pathways in Planar Polarity and wingless Signaling

1998 • 774 citations

The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun

1993 • 769 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways

1999 • 699 citations

CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines.

1989 • 662 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

Development of coronary artery disease in cardiac transplant patients receiving immunosuppressive therapy with cyclosporine and prednisone.

1987 • 549 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

Nuclear factor of activated T cells contains Fos and Jun

1992 • 495 citations

A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A

1997 • 493 citations

Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in aG-protein-dependent manner

1999 • 476 citations

Lithium Reduces Tau Phosphorylation by Inhibition of Glycogen Synthase Kinase-3

1997 • 459 citations

Hyperproliferation and Dysregulation ofIL-4 Expression in NF-ATp-Deficient Mice

1996 • 456 citations

Wnt Signaling Regulates B Lymphocyte Proliferation through a LEF-1 Dependent Mechanism

2000 • 444 citations

Wingless inactivates glycogen synthase kinase-3 via an intracellular signalling pathway which involves a protein kinase C.

1996 • 396 citations

Differential regulation of glycogen synthase kinase-3 beta by protein kinase C isotypes.

1992 • 394 citations

Cardiac transplant atherosclerosis.

1987 • 359 citations

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

1987 • 354 citations

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

1995 • 347 citations

Role of Members of the Wnt Gene Family in Human Hematopoiesis

1998 • 333 citations

Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells.

1991 • 325 citations

The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos

2002 • 308 citations

Selective Inhibition of NFAT Activation by a Peptide Spanning the Calcineurin Targeting Site of NFAT

1998 • 298 citations

Frizzled-7 signalling controls tissue separation during Xenopus gastrulation

2001 • 259 citations

Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin

1998 • 258 citations

Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: roles for NF-Y and NF-ATc.

1993 • 245 citations

Wnt Signaling to β-Catenin Involves Two Interactive Components

2000 • 220 citations

Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter.

1993 • 202 citations

Nuclear Factor of Activated T Cells (NFAT)-dependent Transactivation Regulated by the Coactivators p300/CREB-binding Protein (CBP)

1998 • 193 citations

Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

2001 • 193 citations

Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter

1993 • 191 citations

Overexpression of Protein Kinase C βII Induces Colonic Hyperproliferation and Increased Sensitivity to Colon Carcinogenesis

1999 • 182 citations

Expression of NFAT-Family Proteins in Normal Human T Cells

1997 • 176 citations

Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import.

1996 • 173 citations

Negative Regulation of T Cell Proliferation and Interleukin 2 Production by the Serine Threonine Kinase Gsk-3

2000 • 162 citations

Endothelial cells augment T cell interleukin 2 production by a contact-dependent mechanism involving CD2/LFA-3 interaction.

1990 • 143 citations

The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription.

1994 • 134 citations

The Duration of Nuclear Residence of NFAT Determines the Pattern of Cytokine Expression in Human SCID T Cells

2000 • 132 citations

T-Cell Receptor Stimulation Elicits an Early Phase of Activation and a Later Phase of Deactivation of the Transcription Factor NFAT1

1996 • 129 citations

Identification of a Wnt-Responsive Signal Transduction Pathway in Primary Endothelial Cells

1999 • 123 citations

The CD40L Promoter Contains Nuclear Factor of Activated T Cells-binding Motifs Which Require AP-1 Binding for Activation of Transcription

1996 • 119 citations

Identification of a Physical Interaction between Calcineurin and Nuclear Factor of Activated T Cells (NFATp)

1996 • 104 citations

Phosphorylation of the Transcription Factor NFATp Inhibits Its DNA Binding Activity in Cyclosporin A-treated Human B and T Cells

1995 • 96 citations

T-cell Activation Leads to Rapid Stimulation of Translation Initiation Factor eIF2B and Inactivation of Glycogen Synthase Kinase-3

1996 • 95 citations

Differences in phorbol-ester-induced down-regulation of protein kinase C between cell lines

1989 • 93 citations

Identification of multiple PKC isoforms in Swiss 3T3 cells: Differential down‐regulation by phorbol ester

1992 • 90 citations

Wnt Signaling and Heterotrimeric G-Proteins: Strange Bedfellows or a Classic Romance?

2001 • 90 citations

Regulation of the Protein Kinase Activity of ShaggyZeste-white3 by Components of the Wingless Pathway in Drosophila Cells and Embryos

1999 • 88 citations

The Early Growth Response Protein (EGR-1) Regulates Interleukin-2 Transcription by Synergistic Interaction with the Nuclear Factor of Activated T Cells

1998 • 83 citations

Endothelial cell lymphocyte function-associated antigen-3 and an unidentified ligand act in concert to provide costimulation to human peripheral blood CD4+ T cells

1991 • 65 citations

Dermal Microvascular Injury in the Human Peripheral Blood Lymphocyte Reconstituted-Severe Combined Immunodeficient (HuPBL-SCID) Mouse/Skin Allograft Model Is T Cell Mediated and Inhibited by a Combination of Cyclosporine and Rapamycin

1998 • 59 citations

Activation of Nuclear Factor of Activated T Cells in a Cyclosporin A-resistant Pathway

1996 • 50 citations

Endothelial cell-induced resistance to cyclosporin A in human peripheral blood T cells requires contact-dependent interactions involving CD2 but not CD28.

1994 • 30 citations

Is acute cardiac rejection a model of myocarditis in humans?

1987 • 26 citations

Single-Cell Analysis of Costimulation by B Cells, Endothelial Cells, and Fibroblasts Demonstrates Heterogeneity in Responses of CD4+ Memory T Cells

1999 • 21 citations

Cyclosporin A-Resistant Transactivation of the IL-2 Promoter Requires Activity of Okadaic Acid-Sensitive Serine/Threonine Phosphatases

1998 • 16 citations