Formation of Excess Reactive Oxygen Species within the Brain

Free radicals in biology and medicine

1991 • 17,840 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress

1992 • 2,536 citations

β-Carotene: an Unusual Type of Lipid Antioxidant

1984 • 2,147 citations

Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 • 2,052 citations

Role of metals in oxygen radical reactions

1985 • 1,149 citations

Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences

1990 • 1,143 citations

Hippocampal damage associated with prolonged glucocorticoid exposure in primates

1990 • 1,092 citations

Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress

1989 • 987 citations

Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids

1980 • 925 citations

Role of oxygen free radicals in carcinogenesis and brain ischemia

1990 • 885 citations

Oxygen radicals and the nervous system

1985 • 822 citations

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

1990 • 787 citations

Parkinson's disease: A disorder due to nigral glutathione deficiency?

1982 • 746 citations

Cerebral hypoxia: some new approaches and unanswered questions

1990 • 674 citations

Albumin—An important extracellular antioxidant?

1988 • 643 citations

Central nervous systems trauma and strokeI. Biochemical considerations for oxygen radical formation and lipid peroxidation

1989 • 626 citations

Central nervous system trauma and strokeII. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation

1989 • 580 citations

Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia-induced neuronal damage

1990 • 510 citations

Oxidants and the central nervous system: some fundamental questions. Is oxidant damage relevant to Parkinson's disease, Alzheimer's disease, traumatic injury or stroke?

1989 • 471 citations

A Selective Increase in Particulate Superoxide Dismutase Activity in Parkinsonian Substantia Nigra

1989 • 445 citations

Oxygen free radical involvement in ischemia and reperfusion injury to brain

1988 • 429 citations

Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

1989 • 414 citations

Protection against tissue damage in vivo by desferrioxamine: What is its mechanism of action?

1989 • 385 citations

Acidosis and ischemic brain damage

1988 • 378 citations

DATATOP: A Multicenter Controlled Clinical Trial in Early Parkinson's Disease

1989 • 337 citations

Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue Injury

1987 • 334 citations

Organometal-induced increases in oxygen reactive species: The potential of 2′,7′-dichlorofluorescin diacetate as an index of neurotoxic damage

1990 • 312 citations

Sensitive and rapid quantitation of oxygen reactive species formation in rat synaptosomes

1990 • 309 citations

Effects of the 21-aminosteroid U74006F on experimental head injury in mice

1988 • 296 citations

Free radical generation by redox cycling of estrogens

1990 • 293 citations

Lead-induced regional lipid peroxidation in brain

1984 • 279 citations

Methamphetamine-induced neuronal damage: A possible role for free radicals

1989 • 271 citations

Uncoupling of oxidative phosphorylation

1976 • 265 citations

Hemoglobin potentiates central nervous system damage.

1987 • 262 citations

Mechanism of calcium potentiation of oxygen free radical injury to renal mitochondria. A model for post-ischemic and toxic mitochondrial damage.

1986 • 258 citations

Oxygen Radicals and Tissue Injury

1997 • 257 citations

Decreased Ferritin Levels in Brain in Parkinson's Disease

1990 • 254 citations

Oxygen Radicals in Brain Injury

1986 • 244 citations

Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat

1987 • 241 citations

Ethanol inhibits NMDA-induced increases in free intracellular Ca2+ in dissociated brain cells

1989 • 241 citations

Oxygen radicals in CNS damage

1989 • 226 citations

Free radical generation during brief period of cerebral ischemia may trigger delayed neuronal death

1990 • 216 citations

Phospholipase D activation is functionally linked to superoxide generation in the human neutrophil

1989 • 204 citations

Cellular Antioxidant Defense Mechanisms

2019 • 203 citations

Do environmental toxins cause Parkinson's disease? A critical review.

1990 • 200 citations

The role of iron in oxygen radical mediated lipid peroxidation

1989 • 198 citations

Cellular responses to oxidative stress: the [Ah] gene battery as a paradigm.

1990 • 197 citations

Superoxide dismutase activity in Alzheimer's disease: possible mechanism for paired helical filament formation

1989 • 193 citations

Increased indices of free radical activity in the cerebrospinal fluid of patients with tardive dyskinesia

1990 • 177 citations

Effects of the 21-aminosteroid U74006F on posttraumatic spinal cord ischemia in cats

1988 • 176 citations

Role of nerve growth factor in oxidant‐antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance

1990 • 164 citations

Overexpression of Cu-Zn superoxide dismutase in Drosophila does not affect life-span.

1990 • 162 citations

MK-801 prevents hypobaric-ischemic neuronal degeneration in infant rat brain

1989 • 161 citations

Generation of hydrogen peroxide by brain mitochondria: The effect of reoxygenation following postdecapitative ischemia

1989 • 145 citations

Some features of the nigrostriatal dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse

1989 • 141 citations

Lipid peroxidation and antioxidant systems in the liver injury produced by glutathione depleting agents

1990 • 134 citations

Postischemic Cerebral Lipid Peroxidation In Vitro: Modification by Dietary Vitamin E

1985 • 129 citations

Enhanced autoxidation of dopamine as a possible basis of manganese neurotoxicity.

1981 • 128 citations

Excitotoxicity of l-DOPA and 6-OH-DOPA: Implications for Parkinson's and Huntington's diseases

1990 • 127 citations

Increased free intrasynaptosomal Ca2+ by neurotoxic organometals: Distinctive mechanisms

1987 • 126 citations

Injection of excitatory amino acid antagonists into the medial pallidal segment of a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated primate reverses motor symptoms of parkinsonism

1990 • 116 citations

Near-Total Glutathione Depletion and Age-Specific Cataracts Induced by Buthionine Sulfoximine in Mice

1986 • 115 citations

A new aspect of the protective functions of the blood-brain barrier: Activities of four drug-metabolizing enzymes in isolated rat brain microvessels

1988 • 109 citations

Microsomal lipid peroxidation: The role of NADPH — Cytochrome P450 reductase and cytochrome P450

1990 • 103 citations

Redox modulation of NMDA receptor-mediated toxicity in mammalian central neurons

1990 • 103 citations

Biological role of superoxide ion-radical

1988 • 102 citations

Low glutathione levels in brain regions of aged rats

1989 • 98 citations

Calcium and Ischemic Brain Damage

1986 • 95 citations

Vitamin E and neurologic function in man

1989 • 95 citations

Short-term toxicity of trans, trans-muconaldehyde

1985 • 91 citations

Mechanisms of hypoxic cell injury

1990 • 91 citations

ORGANIC MERCURIAL ENCEPHALOPATHY: IN VIVO AND IN VITRO EFFECTS OF METHYL MERCURY ON SYNAPTOSOMAL RESPIRATION

1975 • 88 citations

Enzymatic Protection Against Peroxidative Damage in Isolated Brain Capillaries

1987 • 86 citations

Detection of free radical formation in various tissues after acute carbon tetrachloride administration in gerbil

1987 • 84 citations

VITAMIN E SUPPLEMENTATION REDUCES FREQUENCY OF PERIVENTRICULAR HAEMORRHAGE IN VERY PRETERM BABIES

1987 • 81 citations

Aluminum neurotoxicity: altered expression of cytoskeletal genes

1988 • 81 citations

Effect of ethanol on intracellular ionized calcium concentrations in synaptosomes and hepatocytes.

1987 • 80 citations

Peroxidation of brain lipids following cyanide intoxication in mice

1987 • 79 citations

Superoxide dismutase and glutathione peroxidase activities in rat brain.

1978 • 79 citations

GM1 ganglioside-induced recovery of nigrostriatal dopaminergic neurons after MPTP: an immunohistochemical study

1989 • 76 citations

Regulation of γ‐Aminobutyric Acid/Barbiturate Receptor‐Gated Chloride Ion Flux in Brain Vesicles by Phospholipase A₂: Possible Role of Oxygen Radicals

1988 • 75 citations

Effects of toluene and its metabolites on cerebral reactive oxygen species generation

1991 • 73 citations

Stimulation of phospholipase A₂ activity by oxygen‐derived free radicals in isolated brain capillaries

1985 • 73 citations

Cerebral Superoxide Anion Generation during Seizures in Newborn Pigs

1989 • 71 citations

Rapid increase in blood-brain barrier permeability during severe hypoxia and metabolic inhibition

1986 • 71 citations

Oxygen Radicals: Systemic Events and Disease Processes

1991 • 69 citations

Oxygen radicals from acetaldehyde

1989 • 67 citations

Effects of thallium, nickel, and cobalt administration on the lipid peroxidation in different regions of the rat brain

1981 • 66 citations

Modification of methylmercury neurotoxicity by vitamin E

1978 • 66 citations

Age‐Dependent Variations in Peroxide‐Utilizing Enzymes from Rat Brain Mitochondria and Cytoplasm

1984 • 65 citations

The multimolecular cascade of spinal cord injury

1987 • 63 citations

Lipid peroxidation: A possible mechanism of trichloroethylene-induced nephrotoxicity

1989 • 58 citations

MPTP toxicity in the mouse brain and vitamin E

1990 • 57 citations

Distribution of cytochrome p450 activities towards alkoxyresorufin derivatives in rat brain regions, subcellular fractions and isolated cerebral microvessels

1990 • 57 citations

Monosialoganglioside GM1 protects against anoxia-induced neuronal death in vitro

1989 • 56 citations

Detection of 2,5-hexanedione in the urine of persons not exposed to n-hexane

1986 • 54 citations

Electrically stimulated rapid gene expression in the brain: ornithine decarboxylase and c-fos

1990 • 49 citations

Trialkyllead metabolism and lipid peroxidation in vivo in vitamin E- and selenium-deficient rats, as measured by ethane production

1980 • 48 citations

GM1 Ganglioside treatment after global ischemia protects changes in membrane fatty acids and properties of Na+, K+‐ATPase and Mg2+‐ATPase

1989 • 47 citations

Chronic treatment with prolixin causes oxidative stress in rat brain

1990 • 47 citations

Effect of a superoxide dismutase derivative on cold-induced brain edema

1989 • 47 citations

Effect of Peroxide, Sodium, and Calcium on Brain Mitochondrial Respiration In Vitro: Potential Role in Cerebral Ischemia and Reperfusion

1990 • 45 citations

Oxidative stress from alcohol in the brain.

1987 • 41 citations

Free radical mechanisms in chemical pathogenesis

1988 • 41 citations

Superoxide dismutase and cytochrome oxidase activities in light and heavy synaptic mitochondria from rat cerebral cortex during aging

1989 • 40 citations

Persistent protein damage despite reduced oxygen radical formation in the aging rat brain

1991 • 39 citations

Age-dependent alterations in the physicochemical properties of rat liver microsomes

1984 • 38 citations

Ethanol-induced oxidative stress in the rat cerebellum.

1987 • 38 citations

Deprenyl and tocopherol antioxidative therapy of parkinsonism (DATATOP)

1989 • 37 citations

n-Hexane induces Parkinsonism in rodents

1990 • 37 citations

Effect of acute ethanol administration on the subcellular distribution of iron in rat liver and cerebellum

1990 • 36 citations

Altered synaptosomal phospholipid metabolism after toluene: possible relationship with membrane fluidity, Na+,K(+)-adenosine triphosphatase and phospholipid methylation.

1990 • 35 citations

Changes in lipid peroxidation induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium in mouse brain homogenates

1987 • 35 citations

Protective effect of the iron chelator deferoxamine on cold-induced brain edema

1989 • 35 citations

The role of free radicals and eicosanoids in the pathogenetic mechanism underlying ischemic brain edema

1989 • 33 citations

Glycine synergistically potentiates the enhancement of LTP induced by a sulfhydryl reducing agent

1990 • 32 citations

Cerebellar Calification: A Possible Marker of Lead Poisoning

1977 • 32 citations

Cellular antioxidant defense mechanisms

1989 • 31 citations

Inhibition of cardiac phosphatidylethanolamine N-methylation by oxygen free radicals

1990 • 31 citations

Eicosanoids, plasma membranes, and molecular mechanisms of spinal cord injury

1987 • 31 citations

Endothelium-derived relaxing factor (nitric oxide), lipoprotein oxidation and atherosclerosis

1990 • 28 citations

Prevention of chemically induced synaptosomal changes

1990 • 23 citations

The Neurotoxicity of MPTP and the Relevance to Parkinson's Disease

1990 • 23 citations

Regional blood flow in compression‐induced brain edema in rats: Effect of dietary vitamin E

1984 • 23 citations

Prevention of cadmium‐induced effects on regional glutathione status of rat brain by vitamin E

1988 • 23 citations

The influence of pH on OH scavenger inhibition of damage to deoxyribose by Fenton reaction

1990 • 23 citations

Iron and oxygen radicals in tissue damage: implications for the neuronal ceroid lipofuscinoses

1983 • 22 citations

Intracellular calcium and neurotoxic events

1989 • 21 citations

Decreased peroxidative potential in rat brain microsomal fractions during ageing

1989 • 20 citations

Triethyllead‐induced peroxidative damage in various regions of the rat brain

1989 • 19 citations

Alteration of α‐Tocopherol Content in the Developing and Aging Peripheral Nervous System: Persistence of High Correlations with Total and Specific (n‐6) Polyunsaturated Fatty Acids

1990 • 18 citations

Oxygen radicals: systemic events and disease processes

1990 • 16 citations

Desferrioxamine-induced alterations in hepatic iron distribution, DNA damage and lipid peroxidation in control and 2, 3, 7,8-tetrachlorodibenzo-p-dioxin-treated rats

1990 • 14 citations

Drug Trial for Parkinson's

1987 • 12 citations

Micronutrients, superoxide and the fetus.

1987 • 12 citations

Net transport of glucose from blood to cerebrospinal fluid in the cat

1983 • 11 citations

7 Free Radicals, Central Nervous System Processes and Brain Functions

2015 • 11 citations

Dexamethasone treatment attenuates the development of ischaemic brain oedema in gerbils

1990 • 9 citations

Protection with butylated hydroxytoluene and other compounds against intoxication and mortality caused by hexachlorophene

1984 • 8 citations

The biochemical evaluation of neurotoxic damage

1986 • 8 citations

Changes in synaptosomal pH and rates of oxygen radical formation induced by chlordecone

1990 • 6 citations

Can brain lesions occur in experimental animals by administration of ethanol or acetaldehyde?

1987 • 6 citations

Excitotoxins and free radicals: accomplices in post-ischemic and other neurodegeneration

1990 • 4 citations

Deleted Work

1955 • 0 citations