The interferon regulatory factors and oncogenesis

The Hallmarks of Cancer

2000 • 27,569 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

Biology of Natural Killer Cells

1989 • 2,970 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

1998 • 1,040 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV

1996 • 926 citations

Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

1998 • 901 citations

Reversible Tumorigenesis by MYC in Hematopoietic Lineages

1999 • 871 citations

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

1994 • 840 citations

Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo

1998 • 723 citations

The Action of Oncogenes in the Cytoplasm and Nucleus

1985 • 708 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene

1996 • 650 citations

Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity

1998 • 602 citations

Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

1997 • 581 citations

Interferon regulatory factors: the next generation

1999 • 550 citations

Positive feedback regulation of type I IFN genes by the IFN‐inducible transcription factor IRF‐7

1998 • 546 citations

Oncoprotein Networks

1997 • 532 citations

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

1994 • 490 citations

The growing family of interferon regulatory factors

1997 • 480 citations

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

1995 • 451 citations

Anti-Oncogenic and Oncogenic Potentials of Interferon Regulatory Factors-1 and -2

1993 • 449 citations

Interferons and other regulatory cytokines

1988 • 429 citations

Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system.

1993 • 416 citations

Deletion of IRF-1 , Mapping to Chromosome 5q31.1, in Human Leukemia and Preleukemic Myelodysplasia

1993 • 392 citations

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.

1992 • 387 citations

Structure of IRF-1 with bound DNA reveals determinants of interferon regulation

1998 • 385 citations

Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated

1990 • 377 citations

Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

1989 • 368 citations

An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes.

1990 • 368 citations

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

1997 • 364 citations

Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.

1994 • 359 citations

KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway

1997 • 358 citations

Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1

1997 • 354 citations

Requirement for IRF-1 in the microenvironment supporting development of natural killer cells

1998 • 352 citations

Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma

1997 • 351 citations

Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double-Stranded RNA-Activated Transcription Factor DRAF1

1998 • 334 citations

The 5q− anomaly

1985 • 330 citations

Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

1996 • 326 citations

Involvement of the IRF-1 Transcription Factor in Antiviral Responses to Interferons

1994 • 306 citations

Interferons and other regulatory cytokines

1989 • 306 citations

Induction of the transcription factor IRF-1 and interferon-beta mRNAs by cytokines and activators of second-messenger pathways.

1989 • 292 citations

Transgenic Models of Tumor Development

1991 • 289 citations

Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.

1994 • 288 citations

Interferon Regulatory Factor-1 Is Required for a T Helper 1 Immune Response In Vivo

1997 • 286 citations

Human β-interferon gene expression is regulated by an inducible enhancer element

1985 • 283 citations

Involvement of the IRF family transcription factor IRF‐3 in virus‐induced activation of the IFN‐β gene

1998 • 262 citations

Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF.

1993 • 241 citations

Molecular cloning ofLSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)

1995 • 237 citations

Overlapping positive and negative regulatory domains of the human beta-interferon gene.

1988 • 237 citations

Expression of Gene rrg Is Associated with Reversion of NIH 3Tt3 Transformed by LTR-c-H- ras

1990 • 224 citations

Lack of Interferon Consensus Sequence Binding Protein (ICSBP) Transcripts in Human Myeloid Leukemias

1998 • 207 citations

Lysyl Oxidase and rrg Messenger RNA

1991 • 205 citations

A Novel Interferon Regulatory Factor Family Transcription Factor, ICSAT/Pip/LSIRF, That Negatively Regulates the Activity of Interferon-Regulated Genes

1996 • 197 citations

Activation of a cell-cycle-regulated histone gene by the oncogenic transcription factor IRF-2

1995 • 192 citations

PU.1, Interferon Regulatory Factor 1, and Interferon Consensus Sequence-binding Protein Cooperate to Increase gp91 Expression

1998 • 178 citations

Identification and characterization of nucleophosmin/B23/numatrin which binds the anti-oncogenic transcription factor IRF-1 and manifests oncogenic activity

1997 • 177 citations

Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA

1997 • 162 citations

Interferon regulatory factor 1 is a myeloid differentiation primary response gene induced by interleukin 6 and leukemia inhibitory factor: role in growth inhibition.

1991 • 155 citations

Expression of Interferon Consensus Sequence Binding Protein (ICSBP) Is Downregulated in Bcr-Abl-Induced Murine Chronic Myelogenous Leukemia-Like Disease, and Forced Coexpression of ICSBP Inhibits Bcr-Abl-Induced Myeloproliferative Disorder

2000 • 150 citations

ISGF3γ p48, a specificity switch for interferon activated transcription factors

1996 • 131 citations

Unique properties of a second human herpesvirus 8-encoded interferon regulatory factor (vIRF-2).

1999 • 126 citations

Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53

1999 • 123 citations

IRF-1: the transcription factor linking the interferon response and oncogenesis

1997 • 121 citations

Accelerated exon skipping of IRF-1 mRNA in human myelodysplasia/leukemia; a possible mechanism of tumor suppressor inactivation.

1994 • 115 citations

Two distinct regions of deletion on the long arm of chromosome 5 in differentiated adenocarcinomas of the stomach.

1996 • 106 citations

Expression of IFN regulatory factor family proteins in lymphocytes. Induction of Stat-1 and IFN consensus sequence binding protein expression by T cell activation.

1996 • 105 citations

Functional Domain Analysis of Interferon Consensus Sequence Binding Protein (ICSBP) and Its Association with Interferon Regulatory Factors

1995 • 99 citations

Mouse models in tumor suppression

1998 • 97 citations

Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV

1998 • 94 citations

Structure and Regulation of the Human Interferon Regulatory Factor 1 (IRF-1) and IRF-2 Genes: Implications for a Gene Network in the Interferon System

1994 • 91 citations

Common deleted region on the long arm of chromosome 5 in esophageal carcinoma

1996 • 90 citations

Identification of the lysyl oxidase gene as target of the antioncogenic transcription factor, IRF-1, and its possible role in tumor suppression.

1996 • 87 citations

Cell Cycle Regulation of Histone H4 Gene Transcription Requires the Oncogenic Factor IRF-2

1998 • 84 citations

Functionally inactivating point mutation in the tumor-suppressorIRF-1 gene identified in human gastric cancer

1998 • 84 citations

Suppression of c-myc or fosB-induced cell transformation by the transcription factor IRF-1

1994 • 81 citations

Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons.

1997 • 77 citations

Allelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: retention of IRF1 on the 5q- chromosome in some patients with the 5q- syndrome

1993 • 58 citations

Transcription factor IRF-2 exerts its oncogenic phenotype through the DNA binding/transcription repression domain.

1995 • 49 citations

Assignment of the human interferon regulatory factor-1 (IRF1) gene to chromosome 5q23–q31

1991 • 46 citations

The interferon-inducible murine p48 (ISGF3γ) gene is regulated by protooncogene c- myc

1997 • 39 citations

ICSAT Overexpression Is Not Sufficient to Cause Adult T-Cell Leukemia or Multiple Myeloma

1999 • 17 citations

Modulation of Exon Skipping and Inclusion by Heterogeneous Nuclear Ribonucleoprotein A1 and Pre-mRNA Splicing Factor SF2/ASF

1993 • 11 citations