The RACK1 Signaling Scaffold Protein Selectively Interacts with the cAMP-specific Phosphodiesterase PDE4D5 Isoform

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

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Antibodies: A laboratory manual

1989 • 4,532 citations

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1997 • 2,268 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

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1995 • 1,780 citations

The ancient regulatory-protein family of WD-repeat proteins

1994 • 1,478 citations

The 2.0 Å crystal structure of a heterotrimeric G protein

1996 • 1,118 citations

The structure of the G protein heterotrimer Giα1β1γ2

1995 • 1,091 citations

Localization of Protein Kinases by Anchoring Proteins: a Theme in Signal Transduction

1995 • 911 citations

Complexity and Diversity of Mammalian Adenylyl Cyclases

1996 • 857 citations

Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins.

1994 • 715 citations

Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors

1992 • 703 citations

Vectors that facilitate the expression and purification of foreign peptides in Escherichia coli by fusion to maltose-binding protein

1988 • 662 citations

Identification of intracellular receptor proteins for activated protein kinase C.

1991 • 505 citations

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

1993 • 476 citations

Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase

1996 • 406 citations

Microinjected antibodies against the cytoplasmic domain of vesicular stomatitis virus glycoprotein block its transport to the cell surface.

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[16] Analyzing protein-protein interactions using two-hybrid system

1995 • 364 citations

Rack1, a Receptor for Activated Protein Kinase C, Interacts with Integrin β Subunit

1998 • 351 citations

C2 Region-derived Peptides Inhibit Translocation and Function of β Protein Kinase C in Vivo

1995 • 322 citations

The Multienzyme PDE4 Cyclic Adenosine Monophosphate–Specific Phosphodiesterase Family: Intracellular Targeting, Regulation, and Selective Inhibition by Compounds Exerting Anti-inflammatory and Antidepressant Actions

1998 • 292 citations

A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP.

1994 • 291 citations

A Family of Human Phosphodiesterases Homologous to the Dunce Learning and Memory Gene Product of Drosophila melanogaster are Potential Targets for Antidepressant Drugs

1993 • 287 citations

RACK1, a Receptor for Activated C Kinase and a Homolog of the β Subunit of G Proteins, Inhibits Activity of Src Tyrosine Kinases and Growth of NIH 3T3 Cells

1998 • 257 citations

The Coatomer Protein β′-COP, a Selective Binding Protein (RACK) for Protein Kinase Cε

1997 • 251 citations

An autoregulatory region in protein kinase C: the pseudoanchoring site.

1995 • 199 citations

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene

1997 • 186 citations

Proposal for Pharmacologically Distinct Conformers of PDE4 Cyclic AMP Phosphodiesterases

1997 • 185 citations

The short-term activation of a rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation.

1994 • 183 citations

Folding of Proteins with WD-Repeats: Comparison of Six Members of the WD-Repeat Superfamily to the G Protein β Subunit

1996 • 175 citations

A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes

1980 • 174 citations

cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model

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Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

1993 • 133 citations

The ratPDE3/IVd phosphodiesterase gene codes for multiple proteins differentially activated by cAMP-dependent protein kinase

1994 • 132 citations

Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex.

1989 • 129 citations

Activation and selective inhibition of a cyclic AMP-specific phosphodiesterase, PDE-4D3.

1995 • 127 citations

Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

1995 • 113 citations

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3

1997 • 101 citations

The Human Cyclic AMP-specific Phosphodiesterase PDE-46 (HSPDE4A4B) Expressed in Transfected COS7 Cells Occurs as Both Particulate and Cytosolic Species That Exhibit Distinct Kinetics of Inhibition by the Antidepressant Rolipram

1996 • 99 citations

The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5)

1996 • 99 citations

Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum

1995 • 93 citations

Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex.

1996 • 87 citations

Subcellular Localization of Rolipram-sensitive, cAMP-specific Phosphodiesterases

1998 • 85 citations

Alternative Splicing of cAMP-specific Phosphodiesterase mRNA Transcripts

1996 • 82 citations

Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase

1995 • 72 citations

Protein Targeting Protocols

1998 • 54 citations

Identification of cyclic AMP‐phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells

1996 • 40 citations

Molecular Cloning and Expression of a Human Phosphodiesterase 4C

1997 • 30 citations