Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin.

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Methods in yeast genetics

1979 • 7,824 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

1985 • 2,298 citations

A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector

1987 • 1,181 citations

Type II DNA topoisomerases: Enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break

1980 • 547 citations

DNA topoisomerase-targeting antitumor drugs can be studied in yeast.

1988 • 490 citations

Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA

1987 • 426 citations

Inhibitors of DNA topoisomerases

1988 • 340 citations

Recent studies of DNA topoisomerases

1987 • 323 citations

Phase I clinical trial of weekly and daily treatment with camptothecin (NSC-100880): correlation with preclinical studies.

1972 • 315 citations

Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin.

1988 • 314 citations

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

1987 • 291 citations

cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment.

1988 • 260 citations

Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae

1989 • 250 citations

Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC-100880).

1970 • 246 citations

DNA topoisomerases as targets for cancer therapy

1985 • 197 citations

Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene.

1985 • 193 citations

Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II.

1985 • 168 citations

Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogs. Structure-activity correlations

1987 • 113 citations

Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.

1988 • 93 citations

DNA supercoiling in vivo

1988 • 80 citations

Probing the structural domains and function in vivo of Escherichia coli DNA topoisomerase I by mutagenesis

1986 • 74 citations

Expression of yeast DNA topoisomerase I can complement a conditional-lethal DNA topoisomerase I mutation in Escherichia coli.

1987 • 66 citations

Intercalator-induced, toposiomerase II-mediated DNA cleavage and its modification by antineoplastic antimetabolites

1986 • 21 citations

DNA topoisomerases: from a laboratory curiosity to a subject in cancer chemotherapy.

1987 • 16 citations