Subunit Assembly and Guanine Nucleotide Exchange Activity of Eukaryotic Initiation Factor-2B Expressed in Sf9 Cells

Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1992 • 768 citations

Initiation of Protein Synthesis in Eukaryotic Cells

1996 • 715 citations

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B

1993 • 399 citations

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.

1992 • 325 citations

Protein Phosphorylation Controls Translation Rates

1989 • 303 citations

Regulation of eukaryotic protein synthesis by initiation factors.

1993 • 300 citations

Translational Control

2013 • 230 citations

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.

1993 • 227 citations

Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins

1995 • 217 citations

Regulation of Protein Synthesis by Insulin

1994 • 198 citations

Translational control of GCN4: an in vivo barometer of initiation-factor activity

1994 • 183 citations

Mutants of the RNA-Dependent Protein Kinase (PKR) Lacking Double-Stranded RNA Binding Domain I Can Act as Transdominant Inhibitors and Induce Malignant Transformation

1995 • 139 citations

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.

1992 • 127 citations

Modulation of tRNA(_i^Met), eIF-2, and eIF-2B Expression Shows that GCN4 Translation Is Inversely Coupled to the Level of eIF-2·GTP·Met-tRNA(_i^Met) Ternary Complexes

1995 • 124 citations

Mechanism of inhibition of peptide chain initiation by amino acid deprivation in perfused rat liver. Regulation involving inhibition of eukaryotic initiation factor 2 alpha phosphatase activity

1991 • 114 citations

Baculovirus Expression Protocols

1995 • 107 citations

Physiological stresses inhibit guanine‐nucleotide‐exchange factor in Ehrlich cells

1988 • 104 citations

Molecular mechanisms in the control of translation by hormones and growth factors

1994 • 101 citations

The guanine nucleotide-exchange factor, eIF-2B

1994 • 101 citations

Phosphorylation of the guanine nucleotide exchange factor from rabbit reticulocytes regulates its activity in polypeptide chain initiation.

1988 • 98 citations

Glucose Stimulates the Activity of the Guanine Nucleotide-exchange Factor eIF-2B in Isolated Rat Islets of Langerhans

1996 • 93 citations

Molecular analysis of GCN3, a translational activator of GCN4: evidence for posttranslational control of GCN3 regulatory function.

1988 • 84 citations

[9] Guanine nucleotide exchange catalyzed by dbl oncogene product

1995 • 76 citations

Guanine nucleotide exchange factors: Activators of Ras superfamily proteins

1995 • 73 citations

The association of NADPH with the guanine nucleotide exchange factor from rabbit reticulocytes: a role of pyridine dinucleotides in eukaryotic polypeptide chain initiation.

1986 • 72 citations

Regulation of protein synthesis in Swiss 3T3 fibroblasts. Rapid activation of the guanine-nucleotide-exchange factor by insulin and growth factors

1992 • 70 citations

Mechanism of the inhibition of protein synthesis by vasopressin in rat liver.

1990 • 62 citations

Use of monoclonal antibodies to study the structure and function of eukaryotic protein synthesis initiation factor eIF‐2B

1994 • 60 citations

Effect of diabetes on guanine nucleotide exchange factor activity in skeletal muscle and heart

1988 • 59 citations

Purification and characterization of eukaryotic initiation factor 2 and a guanine nucleotide exchange factor from rat liver.

1987 • 56 citations

The effect of Mg2+ and guanine nucleotide exchange factor on the binding of guanine nucleotides to eukaryotic initiation factor 2.

1988 • 55 citations

Purification and characterization of eukaryotic translational initiation factor eIF-2B from liver

1994 • 54 citations

The Baculovirus-Infected Insect Cell as a Eukaryotic Gene Expression System

1992 • 51 citations

Photoaffinity labeling of the rabbit reticulocyte guanine nucleotide exchange factor and eukaryotic initiation factor 2 with 8-azidopurine nucleotides

1989 • 48 citations

Effect of starvation and diabetes on the activity of the eukaryotic initiation factor eIF-2 in rat skeletal muscle

1990 • 35 citations

Phosphorylation of the Guanine Nucleotide Exchange Factor and Eukaryotic Initiation Factor 2 by Casein Kinase II Regulates Guanine Nucleotide Binding and GDP/GTP Exchange

1994 • 33 citations

Modulation of Rabbit Reticulocyte Guanine Nucleotide Exchange Factor Activity by Casein Kinases 1 and 2 and Glycogen Synthase Kinase 3

1996 • 30 citations

eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the α, β and δ subunits of eIF2B from mammals and yeast

1996 • 29 citations

Cloning of cDNA for the γ-subunit of mammalian translation initiation factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2

1996 • 20 citations

Allosteric Regulation of Eukaryotic Initiation Factor eIF-2B by Adenine Nucleotides

1995 • 15 citations

Cloning and characterization of complementary and genomic DNAs encoding the ϵ-subunit of rat translation initiation factor-2B

1996 • 12 citations

Cloning and expression of cDNAs for the β subunit of eukaryotic initiation factor-2B, the guanine nucleotide exchange factor for eukaryotic initiation factor-2

1995 • 11 citations

Inhibition of Rabbit Reticulocyte Guanine Nucleotide Exchange Factor Activity by Heparin and Its Reversal by Polyamines

1995 • 6 citations

Structure and sequence of the gene encoding the α-subunit of rat translation initiation factor-2B

1995 • 4 citations

[15] Characterization of breakpoint cluster region kinase and SH2-binding activities

1995 • 3 citations

[13] Purification of baculovirus-expressed human Sos 1 protein

1995 • 3 citations