Phosphorylation of the Guanine Nucleotide Exchange Factor and Eukaryotic Initiation Factor 2 by Casein Kinase II Regulates Guanine Nucleotide Binding and GDP/GTP Exchange

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

STRUCTURE AND FUNCTION OF SIGNAL-TRANSDUCING GTP-BINDING PROTEINS

1991 • 630 citations

Regulation of eukaryotic protein synthesis by initiation factors.

1993 • 300 citations

Mutations at a Zn(II) finger motif in the yeast elF-2β gene alter ribosomal start-site selection during the scanning process

1988 • 283 citations

Purification of the eukaryotic initiation factor 2-eukaryotic initiation factor 2B complex and characterization of its guanine nucleotide exchange activity during protein synthesis initiation.

1983 • 203 citations

Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target

1993 • 189 citations

IMPACT OF VIRUS INFECTION ON HOST CELL PROTEIN SYNTHESIS

1987 • 188 citations

Protein Phosphorylation in Translational Control

1992 • 180 citations

[34] Casein kinase II

1983 • 172 citations

Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification.

1985 • 153 citations

Reversible phosphorylation--dephosphorylation determines the localization of rab4 during the cell cycle.

1992 • 149 citations

Phosphorylation inhibits guanine nucleotide exchange on eukaryotic initiation factor 2

1982 • 141 citations

Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit.

1990 • 129 citations

Physiological stresses inhibit guanine‐nucleotide‐exchange factor in Ehrlich cells

1988 • 104 citations

Mutations in the structural genes for eukaryotic initiation factors 2 alpha and 2 beta of Saccharomyces cerevisiae disrupt translational control of GCN4 mRNA.

1989 • 102 citations

Generation of a Mutant Form of Protein Synthesis Initiation Factor eIF-2 Lacking the Site of Phosphorylation by eIF-2 Kinases

1988 • 99 citations

Phosphorylation of the guanine nucleotide exchange factor from rabbit reticulocytes regulates its activity in polypeptide chain initiation.

1988 • 98 citations

Evidence that GCD6 and GCD7, Translational Regulators of GCN4, Are Subunits of the Guanine Nucleotide Exchange Factor for eIF-2 in Saccharomyces cerevisiae

1993 • 88 citations

The regulation of initiation of protein synthesis by phosphorylation of eIF-2(alpha) and the role of reversing factor in the recycling of eIF-2.

1984 • 79 citations

The association of NADPH with the guanine nucleotide exchange factor from rabbit reticulocytes: a role of pyridine dinucleotides in eukaryotic polypeptide chain initiation.

1986 • 72 citations

Site-specific phosphorylation if initiation factor 2 by three cyclic nucleotide-independent protein kinases.

1980 • 71 citations

Regulation of protein synthesis in Swiss 3T3 fibroblasts. Rapid activation of the guanine-nucleotide-exchange factor by insulin and growth factors

1992 • 70 citations

Purification, phosphorylation and control of the guanine‐nucleotide‐exchange factor from rabbit reticulocyte lysates

1992 • 69 citations

Effect of diabetes on guanine nucleotide exchange factor activity in skeletal muscle and heart

1988 • 59 citations

The effect of Mg2+ and guanine nucleotide exchange factor on the binding of guanine nucleotides to eukaryotic initiation factor 2.

1988 • 55 citations

Mechanism of the Nucleotide Exchange Reaction in Eukaryotic Polypeptide Chain Initiation

1989 • 55 citations

Photoaffinity labeling of the rabbit reticulocyte guanine nucleotide exchange factor and eukaryotic initiation factor 2 with 8-azidopurine nucleotides

1989 • 48 citations

Polyamine binding activity of casein kinase II

1991 • 48 citations

Evidence for simultaneous derepression of messenger RNA and the guanine nucleotide exchange factor in fertilized sea urchin eggs

1987 • 37 citations

Protein synthesis in brine shrimp embryos and rabbit reticulocytes. The effect of Mg2+ on binary (eukaryotic initiation factor 2 X GDP) and ternary (eukaryotic initiation factor 2 X GTP X met-tRNAf) complex formation.

1983 • 37 citations

Placental alkaline phosphatase activity is inversely related to cell growth rate in HeLaS3 cervical cancer cells

1993 • 35 citations

Structure and phosphorylation of eukaryotic initiation factor 2. Casein kinase 2 and protein kinase C phosphorylate distinct but adjacent sites in the β-subunit

1988 • 34 citations

Affinity labeling of eukaryotic initiation factor 2 and elongation factor 1 αβγ with GTP analogs

1990 • 33 citations

Binding of ATP to eukaryotic initiation factor 2. Differential modulation of mRNA-binding activity and GTP-dependent binding of methionyl-tRNAMetf.

1990 • 29 citations

Structural studies on the eukaryotic chain initiation factor 2 from rabbit reticulocytes and brine shrimp Artemia embryos. Phosphorylation by the heme-controlled repressor and casein kinase II.

1986 • 26 citations

The isolation and characterization from rabbit reticulocytes of two forms of eukaryotic initiation factor 2 having different beta-polypeptides.

1987 • 21 citations

The conversion of eIF-2·GDP to eIF-2·GTP by eIF-2B requires Met-tRNAfMet

1991 • 16 citations

Specific phosphorylation of the β subunit of eIF-2 factor from brain by three different protein kinases

1988 • 16 citations

Enhancement of GTP γ S-binding activity by cAMP-dependent phosphorylation of a filamin-like 250 KDa membrane protein in human platelets

1990 • 16 citations

Phosphorylation of Rabbit Reticulocyte Guanine Nucleotide Exchange Factor In vivo. Identification of Putative Casein Kinase II Phosphorylation Sites

1994 • 15 citations

Casein kinase-2 phosphorylates serine-2 in the β-subunit of initiation factor-2

1989 • 14 citations

Alkaline phosphatase activity during sphinganine potentiation of retinoic acid-induced differentiation of human promyelocytic leukemia cell line, HL-60

1993 • 1 citations