eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the α, β and δ subunits of eIF2B from mammals and yeast

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs.

1989 • 618 citations

The C. elegans genome sequencing project: a beginning

1992 • 496 citations

Circumstances and Mechanisms of Inhibition of Translation by Secondary Structure in Eucaryotic mRNAs

1989 • 238 citations

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.

1993 • 227 citations

Translational control of GCN4: an in vivo barometer of initiation-factor activity

1994 • 183 citations

elF-2 kinases: regulators of general and gene-specific translation initiation

1994 • 140 citations

Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma

1992 • 139 citations

Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif.

1990 • 125 citations

Structure of the β subunit of translational initiation factor elF-2

1988 • 122 citations

Elongation factor Tu: a regulatory GTPase with an integrated effector

1994 • 113 citations

The guanine nucleotide-exchange factor, eIF-2B

1994 • 101 citations

Phosphorylation of the guanine nucleotide exchange factor from rabbit reticulocytes regulates its activity in polypeptide chain initiation.

1988 • 98 citations

Elongation factor 1β of artemia: Localization of functional sites and homology to elongation factor 1δ

1990 • 97 citations

Evidence that GCD6 and GCD7, Translational Regulators of GCN4, Are Subunits of the Guanine Nucleotide Exchange Factor for eIF-2 in Saccharomyces cerevisiae

1993 • 88 citations

GCD11, a Negative Regulator of GCN4 Expression, Encodes the γ Subunit of eIF-2 in Saccharomyces cerevisiae

1993 • 84 citations

The association of NADPH with the guanine nucleotide exchange factor from rabbit reticulocytes: a role of pyridine dinucleotides in eukaryotic polypeptide chain initiation.

1986 • 72 citations

Purification, phosphorylation and control of the guanine‐nucleotide‐exchange factor from rabbit reticulocyte lysates

1992 • 69 citations

The subunit structure of elongation factor 1 from Artemia. Why two alpha-chains in this complex?

1994 • 67 citations

Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation.

1994 • 63 citations

Use of monoclonal antibodies to study the structure and function of eukaryotic protein synthesis initiation factor eIF‐2B

1994 • 60 citations

Mechanism of the Nucleotide Exchange Reaction in Eukaryotic Polypeptide Chain Initiation

1989 • 55 citations

Purification and characterization of eukaryotic translational initiation factor eIF-2B from liver

1994 • 54 citations

Mapping the functional domains of the eukaryotic elongation factor 1βγ

1991 • 52 citations

Photoaffinity labeling of the rabbit reticulocyte guanine nucleotide exchange factor and eukaryotic initiation factor 2 with 8-azidopurine nucleotides

1989 • 48 citations

Amino acid sequence similarity between GCN3 and GCD2, positive and negative translational regulators of GCN4: evidence for antagonism by competition.

1989 • 39 citations

Phosphorylation of the Guanine Nucleotide Exchange Factor and Eukaryotic Initiation Factor 2 by Casein Kinase II Regulates Guanine Nucleotide Binding and GDP/GTP Exchange

1994 • 33 citations

Elongation factor 1 contains two homologous guanine-nucleotide exchange proteins as shown from the molecular cloning of beta and delta subunits

1993 • 29 citations

Mutations in the GCD7 Subunit of Yeast Guanine Nucleotide Exchange Factor eIF-2B Overcome the Inhibitory Effects of Phosphorylated eIF-2 on Translation Initiation

1994 • 28 citations

Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase

1994 • 25 citations

Why do two EF-Tu molecules act in the elongation cycle of protein biosynthesis?

1994 • 23 citations

Cloning of cDNA for the γ-subunit of mammalian translation initiation factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2

1996 • 20 citations

The α-Subunit of the Mammalian Guanine Nucleotide-Exchange Factor eIF-2B Is Essential for Catalytic Activity in Vitro

1996 • 17 citations

Guanine nucleotide exchange factor for eukaryotic initiation factor-2. Cloning of cDNA for the δ-subunit of rabbit translation initiation factor-2B

1994 • 15 citations

Allosteric Regulation of Eukaryotic Initiation Factor eIF-2B by Adenine Nucleotides

1995 • 15 citations

Phosphorylation of Rabbit Reticulocyte Guanine Nucleotide Exchange Factor In vivo. Identification of Putative Casein Kinase II Phosphorylation Sites

1994 • 15 citations

Cloning and expression of cDNAs for the β subunit of eukaryotic initiation factor-2B, the guanine nucleotide exchange factor for eukaryotic initiation factor-2

1995 • 11 citations

Molecular cloning and characterization of cDNA encoding the alpha subunit of the rat protein synthesis initiation factor eIF-2B.

1995 • 10 citations

The delta-subunit of murine guanine nucleotide exchange factor eIF-2B. Characterization of cDNAs predicts isoforms differing at the amino-terminal end.

1994 • 8 citations