Kinetics of Interaction of Rab5 and Rab7 with Nucleotides and Magnesium Ions

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Solute perturbation of protein fluorescence. Quenching of the tryptophyl fluorescence of model compounds and of lysozyme by iodide ion

1971 • 1,730 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion

1995 • 476 citations

GTPases: Multifunctional Molecular Switches Regulating Vesicular Traffic

1994 • 411 citations

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

1990 • 410 citations

The Human Rab Genes Encode a Family of GTP-binding Proteins Related to Yeast YPT1 and SEC4 Products Involved in Secretion

1989 • 387 citations

Rabphilin-3A, a Putative Target Protein for smg p25A/rab3A p25 Small GTP-Binding Protein Related to Synaptotagmin

1993 • 386 citations

Rab GTPases in vesicular transport

1993 • 379 citations

Friends and family: The role of the rab GTPases in vesicular traffic

1993 • 364 citations

cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein

1993 • 322 citations

Rab GTPases: master regulators of membrane trafficking

1994 • 315 citations

A quantitative analysis of the endocytic pathway in baby hamster kidney cells.

1989 • 315 citations

Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange

1994 • 313 citations

Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide-binding site.

1986 • 287 citations

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins

1995 • 273 citations

Kinetic and structural analysis of the Mg(2+)-binding site of the guanine nucleotide-binding protein p21H-ras.

1993 • 260 citations

Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin.

1993 • 253 citations

Rab GDP Dissociation Inhibitor: Putting Rab GTPases in the Right Place

1995 • 240 citations

Membrane targeting of the small GTPase Rab9 is accompanied by nucleotide exchange

1994 • 230 citations

The Kinetic Mechanism of Ran-Nucleotide Exchange Catalyzed by RCC1

1995 • 224 citations

Molecular Cloning of YPT1/SEC4-Related cDNAs from an Epithelial Cell Line

1990 • 210 citations

Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C

1994 • 197 citations

Selective recycling of the mannose 6-phosphate/IGF-II receptor to the trans Golgi network in vitro

1988 • 177 citations

A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family

1993 • 171 citations

Molecular cloning of YPT1/SEC4-related cDNAs from an epithelial cell line.

1990 • 132 citations

X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.

1992 • 132 citations

A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4

1993 • 117 citations

DSS4-1 is a dominant suppressor of sec4-8 that encodes a nucleotide exchange protein that aids Sec4p function

1993 • 112 citations

Hydrolysis of GTP by p21NRAS, the NRAS protooncogene product, is accompanied by a conformational change in the wild-type protein: use of a single fluorescent probe at the catalytic site.

1990 • 106 citations

Binding and hydrolysis of guanine nucleotides by Sec4p, a yeast protein involved in the regulation of vesicular traffic.

1990 • 100 citations

Regulation of the GTPase activity of the ras-like protein p25rab3A. Evidence for a rab3A-specific GAP.

1991 • 89 citations

Characterization of a guanine nucleotide-releasing factor and a GTPase-activating protein that are specific for the ras-related protein p25rab3A.

1992 • 88 citations

Is there a rate-limiting step before GTP cleavage by H-ras p21?

1991 • 84 citations

Substrate and Product Structural Requirements for Binding of Nucleotides to H-ras p21: The Mechanism of Discrimination between Guanosine and Adenosine Nucleotides

1995 • 74 citations

Mechanism of GTP hydrolysis by p21N-ras catalyzed by GAP: Studies with a fluorescent GTP analog

1993 • 64 citations

Investigation of the GTP-Binding/GTPase Cycle of Cdc42Hs Using Fluorescence Spectroscopy

1994 • 59 citations

The guanine‐nucleotide binding proteins EMBO‐NATO‐CEC advanced research workshop organized by L. Bosch, B. Kraal and A. Parmeggiani in Renesse, The Netherlands, August 6–11, 1988

1988 • 56 citations

Fly division.

1995 • 43 citations

The N-terminal domain of a rab protein is involved in membrane-membrane recognition and/or fusion.

1994 • 41 citations

Studies on the structure and mechanism of H-ras p21

1992 • 40 citations

KINETIC STUDIES OF ADP REACTIONS WITH THE TEMPERATURE JUMP METHOD

1960 • 40 citations

Interaction of Guanosine Nucleotides and Their Analogs with Elongation Factor Tu from Thermus thermophilus

1995 • 34 citations

The Guanine — Nucleotide Binding Proteins

1989 • 8 citations

Biochemical Properties of Ha-Ras Encoded P21 Mutants

1989 • 6 citations