The relevance of alternative RNA splicing to pharmacogenomics

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

Gene expression profiling predicts clinical outcome of breast cancer

2002 • 9,314 citations

Incidence of Adverse Drug Reactions in Hospitalized Patients

1998 • 4,749 citations

Nitric oxide synthases: structure, function and inhibition

2001 • 3,508 citations

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature

1996 • 2,895 citations

Listening to silence and understanding nonsense: exonic mutations that affect splicing

2002 • 2,143 citations

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression

2002 • 1,963 citations

A genomic view of alternative splicing

2002 • 1,307 citations

Pre-mRNA splicing and human disease

2003 • 1,242 citations

Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS

1990 • 1,234 citations

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

2000 • 1,155 citations

Bim: a novel member of the Bcl-2 family that promotes apoptosis

1998 • 1,154 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity

2000 • 1,067 citations

Predictive Identification of Exonic Splicing Enhancers in Human Genes

2002 • 1,035 citations

An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis

2000 • 847 citations

ALTERNATIVE SPLICING OF PRE-mRNA: Developmental Consequences and Mechanisms of Regulation

1998 • 644 citations

Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-Analysis of Prospective Studies

1999 • 626 citations

Protein Diversity from Alternative Splicing

2000 • 548 citations

Experimental annotation of the human genome using microarray technology

2001 • 446 citations

Signal-dependent regulation of splicing via phosphorylation of Sam68

2002 • 432 citations

IEX -1L, an Apoptosis Inhibitor Involved in NF-κB-Mediated Cell Survival

1998 • 417 citations

Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing.

1995 • 398 citations

STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription

1996 • 378 citations

Mutations affecting mRNA splicing are the most common molecular defects in patients with neurofibromatosis type 1

2000 • 354 citations

ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases

1998 • 350 citations

The Mkk3/6-p38–Signaling Cascade Alters the Subcellular Distribution of Hnrnp A1 and Modulates Alternative Splicing Regulation

2000 • 333 citations

Alternative RNA splicing in the nervous system

2001 • 331 citations

Splicing Defects in the Ataxia-Telangiectasia Gene, ATM: Underlying Mutations and Consequences

1999 • 313 citations

Human Gene Mutation Database?A biomedical information and research resource

2000 • 278 citations

MCL-1S, a Splicing Variant of the Antiapoptotic BCL-2 Family Member MCL-1, Encodes a Proapoptotic Protein Possessing Only the BH3 Domain

2000 • 273 citations

TheIIIcalternative ofFgfr2is a positive regulator of bone formation

2002 • 252 citations

Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)- related toxicity compared with controls.

2001 • 234 citations

Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients

2001 • 233 citations

Bcl-xS Antagonizes the Protective Effects of Bcl-xL

1996 • 200 citations

Exon Skipping in Mcl-1 Results in a Bcl-2 Homology Domain 3 Only Gene Product That Promotes Cell Death

2000 • 184 citations

Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain.

1999 • 178 citations

Bcl-G, a Novel Pro-apoptotic Member of the Bcl-2 Family

2001 • 171 citations

Regulatory Functions of 3′UTRs

2001 • 171 citations

Structural determinants of allosteric regulation in alternatively spliced AMPA receptors

1995 • 164 citations

C-terminal Splice Variants of the Mouse µ-Opioid Receptor Differ in Morphine-induced Internalization and Receptor Resensitization

2001 • 162 citations

The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site.

1990 • 144 citations

Intergenic mRNA Molecules Resulting fromtrans-Splicing

2002 • 142 citations

Alternative Splicing and Programmed Cell Death

1999 • 133 citations

Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB)

2001 • 133 citations

Alternative Splicing Determines the Function of CYP4F3 by Switching Substrate Specificity

2001 • 128 citations

Profound dihydropyrimidine dehydrogenase deficiency resulting from a novel compound heterozygote genotype.

2002 • 124 citations

Predicting Splice Variant from DNA Chip Expression Data

2001 • 121 citations

Distinct in vivo expression patterns of survivin splice variants in renal cell carcinomas

2002 • 121 citations

Differences in Signal Transduction of Two 5-HT₄Receptor Splice Variants: Compound Specificity and Dual Coupling with Gαs- and Gαi/o-Proteins

2002 • 110 citations

Isoform Diversity among Fibroblast Growth Factor Homologous Factors Is Generated by Alternative Promoter Usage and Differential Splicing

2000 • 105 citations

Spatially Distributed Alternative Splice Variants of the Renal Na-K-Cl Cotransporter Exhibit Dramatically Different Affinities for the Transported Ions

2002 • 104 citations

Dopamine D2 Receptor-Mediated Inhibition of Dopaminergic Neurons in Mice Lacking D2L Receptors

2002 • 89 citations

Human deoxycytidine kinase is located in the cell nucleus

1997 • 85 citations

Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade

2002 • 83 citations

Defects in Pre-mRNA Processing as Causes of and Predisposition to Diseases

2002 • 80 citations

Properties and levels of deoxynucleoside kinases in normal and tumor cells; implications for chemotherapy

1994 • 75 citations

Down‐regulation of (IIIb) and (IIIc) isoforms of fibroblast growth factor receptor 2 (FGFR2) is associated with malignant progression in human prostate

2002 • 73 citations

Modification of alternative splicing pathways as a potential approach to chemotherapy

2000 • 73 citations

High CA repeat numbers in intron 13 of the endothelial nitric oxide synthase gene and increased risk of coronary artery disease

2000 • 72 citations

Dopamine D2S and D2L receptors may differentially contribute to the actions of antipsychotic and psychotic agents in mice

2002 • 71 citations

Effects of Subchronic Clozapine and Haloperidol on Striatal Glutamatergic Synapses

1996 • 67 citations

The C‐Terminal Domain of the mGluR1 Metabotropic Glutamate Receptor Affects Sensitivity to Agonists

1996 • 67 citations

A Novel Splice Variant of the Cell Death-promoting Protein BAX

1998 • 62 citations

Opposing actions of adrenal androgens and glucocorticoids on alternative splicing of Slo potassium channels in bovine chromaffin cells

2002 • 61 citations

Functional role of alternatively spliced deoxycytidine kinase in sensitivity to cytarabine of acute myeloid leukemic cells

2002 • 55 citations

Ethanol Regulates Calcium Channel Subunits by Protein Kinase C δ-dependent and -independent Mechanisms

2000 • 47 citations

Control of alternative splicing by antisense oligonucleotides as a potential chemotherapy: effects on gene expression

2002 • 45 citations

Prospective CYP2D6 genotyping as an exclusion criterion for enrollment of a phase III clinical trial

2000 • 42 citations

Alternatively Spliced Products CC3 and TC3 Have Opposing Effects on Apoptosis

2000 • 39 citations

Cloning and Initial Analysis of the Human Multidrug Resistance-Related MVP/LRP Gene Promoter

2000 • 39 citations

Alternative Splicing of CYP2D mRNA in Human Breast Tissue

1997 • 36 citations

Differential influence of etoposide on two caspase-2 mRNA isoforms in leukemic cells

2002 • 32 citations

Spontaneous overexpression of the long form of the Bcl-X protein in a highly resistant P388 leukaemia

1997 • 32 citations

Flip and flop splice variants of AMPA receptor subunits in the spinal cord of amyotrophic lateral sclerosis

2002 • 31 citations

Single-nucleotide polymorphisms, haplotypes, and their relevance to pharmacogenetics

1999 • 31 citations

Alternative Splicing of the mRNA Coding for the Human Endothelial Angiotensin-Converting Enzyme: A New Mechanism for Solubilization

1998 • 30 citations

Ligand Binding Properties of Binary Complexes of Heparin and Immunoglobulin-like Modules of FGF Receptor 2

2000 • 30 citations

Qualitative gene profiling: a novel tool in genomics and in pharmacogenomics that deciphers messenger RNA isoforms diversity

2000 • 25 citations

Expression of mRNAs encoding flip isoforms of GluR1 and GluR2 glutamate receptors is increased in rat hippocampus in epilepsy induced by tetanus toxin

1999 • 21 citations

Spinal Pretreatment with Antisense Oligodeoxynucleotides against Exon-1, -4, or -8 of μ-Opioid Receptor Clone Leads to Differential Loss of Spinal Endomorphin-1-and Endomorphin-2-Induced Antinociception in the Mouse

2002 • 21 citations

Deletion Mutants of Human Deoxycytidine Kinase mRNA in Cells Resistant to Antitumor Cytosine Nucleosides

2001 • 18 citations

β-Amyloid precursor protein (APP) and APP-RNA are rapidly affected by glutamate in cultured neurons

1995 • 17 citations

Alternative splicing patterns of CYP2D genes in human brain and neurodegenerative disorders

1999 • 17 citations

Correspondence re: Raida, M. et al., Prevalence of a Common Point Mutation in the Dihydropyrimidine Dehydrogenase (DPD) Gene within the 5-Splice Donor Site of Intron 14 in Patients with Severe 5-Fluorouracil (5-FU)-related Toxicity Compared with Controls. Clin. Cancer Res., 7: 2832-2839, 2001.

2002 • 16 citations

Different site, different splice

2000 • 6 citations

Splicing 2002: RNA splicing in human pathology

2003 • 3 citations