Spontaneous overexpression of the long form of the Bcl-X protein in a highly resistant P388 leukaemia

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

1984 • 1,477 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

1978 • 645 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1994 • 590 citations

Immunohistochemical analysis of in vivo patterns of Bcl-X expression.

1994 • 429 citations

Expression of bcl-xL can confer a multidrug resistance phenotype

1995 • 421 citations

Role of the Glutathione Redox Cycle in Acquired and de Novo Multidrug Resistance

1988 • 301 citations

Purification of topoisomerase II from amsacrine-resistant P388 leukemia cells. Evidence for two forms of the enzyme.

1987 • 282 citations

DNA damage by antitumor acridines mediated by mammalian DNA topoisomerase II.

1986 • 241 citations

Overexpression of Bcl-XS sensitizes MCF-7 cells to chemotherapy-induced apoptosis.

1995 • 200 citations

Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines.

1990 • 199 citations

Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells.

1993 • 177 citations

Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line

1991 • 156 citations

Mitoxantrone resistance in HL-60 leukemia cells: reduced nuclear topoisomerase II catalytic activity and drug-induced DNA cleavage in association with reduced expression of the topoisomerase II .beta. isoform

1991 • 153 citations

Regulation of Bcl-2 oncoprotein levels with differentiation of human neuroblastoma cells.

1993 • 144 citations

mRNA phenotyping by enzymatic amplification of randomly primed cDNA

1988 • 144 citations

Overexpression of Bcl-XL by cytotoxic drug exposure confers resistance to ionizing radiation-induced internucleosomal DNA fragmentation.

1995 • 133 citations

The Biochemistry Of P-Glycoprotein-Mediated Multidrug Resistance

1989 • 132 citations

Adriamycin: A proposal on the specificity of drug action

1978 • 130 citations

Detection of Multiple Antigens on Western Blots

1996 • 103 citations

Multifactorial mechanisms associated with broad cross-resistance of ovarian carcinoma cells selected by cyanomorpholino doxorubicin.

1991 • 96 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 63 citations

Mdr1 gene expression in childhood acute lymphoblastic leukemias and lymphomas: a critical evaluation by four techniques.

1994 • 60 citations

Evidence for a mutant allele of the gene for DNA topoisomerase II in adriamycin-resistant P388 murine leukemia cells.

1989 • 47 citations

The role of topoisomerase IIα and β in drug resistance

1993 • 41 citations

Measurements of glutathione and other thiols in cells and tissues: A simplified procedure based on the HPLC separation of monobromobimane derivatives of thiols

1984 • 29 citations

The Cancer Research Campaign

2000 • 24 citations

Progressive resistance to doxorubicin in mouse leukemia L1210 cells with multidrug resistance phenotype: reductions in drug-induced topoisomerase II-mediated DNA cleavage.

1989 • 21 citations

Effects of the methoxymorpholino derivative of doxorubicin and its bioactivated form versus doxorubicin on human leukemia and lymphoma cell lines and normal bone marrow

1993 • 12 citations

Multifactorial resistance in LS174T human colon carcinoma cells selected with doxorubicin

1991 • 10 citations