Deletion Mutants of Human Deoxycytidine Kinase mRNA in Cells Resistant to Antitumor Cytosine Nucleosides

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of radiosensitivity.

1987 • 705 citations

Nucleosides and Nucleotides

1973 • 492 citations

Overexpression of ribonucleotide reductase as a mechanism of resistance to 2,2-difluorodeoxycytidine in the human KB cancer cell line.

1999 • 225 citations

Pharmacologically directed design of the dose rate and schedule of 2',2'-difluorodeoxycytidine (Gemcitabine) administration in leukemia.

1990 • 208 citations

Development and molecular characterization of a 2',2'-difluorodeoxycytidine-resistant variant of the human ovarian carcinoma cell line A2780.

1994 • 167 citations

Cloning and expression of human deoxycytidine kinase cDNA.

1991 • 144 citations

Resistance to 1-beta-D-arabinofuranosylcytosine in human T-lymphoblasts mediated by mutations within the deoxycytidine kinase gene.

1992 • 128 citations

High incidence of alternatively spliced forms of deoxycytidine kinase in patients with resistant acute myeloid leukemia

2000 • 84 citations

Nucleosides and nucleotides. 100. 2'-C-Cyano-2'-deoxy-1-.beta.-D-arabinofuranosylcytosine (CNDAC): design of a potential mechanism-based DNA-strand-breaking antineoplastic nucleoside

1991 • 83 citations

Structural analysis of the deoxycytidine kinase gene in patients with acute myeloid leukemia and resistance to cytosine arabinoside.

1994 • 79 citations

Nucleosides and nucleotides. 83. Design, synthesis, and antineoplastic activity of 2'-deoxy-2'-methylidenecytidine

1988 • 72 citations

Nucleosides and nucleotides. 122. 2'-C-Cyano-2'-deoxy-1-.beta.-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum

1993 • 66 citations

Antitumor activity of 2'-deoxy-2'-methylidenecytidine, a new 2'-deoxycytidine derivative.

1991 • 60 citations

Antitumor activity and novel DNA-self-strand-breaking mechanism of CNDAC (1-(2-C-cyano-2-deoxy-?-d-ARABINO-Pentofuranosyl) cytosine) and itsN4-palmitoyl derivative (CS-682)

1999 • 58 citations

Antitumor activity of a novel nucleoside, 2′-C-cyano-2′-deoxy-1-β-d-arabinofuranosylcytosine (CNDAC) against murine and human tumors

1992 • 54 citations

2'-C-Cyano-2'-deoxy-1-β-D-arabinofuranosylcytosine (CNDAC): A Mechanism-Based DNA-Strand-Breaking Antitumor Nucleoside1

1995 • 33 citations

ChemInform Abstract: Nucleosides and Nucleotides. Part 100. 2′-C-Cyano-2′-deoxy-1-β-D- arabinofuranosylcytosine (CNDAC): Design of a Potential Mechanism- Based DNA-Strand-Breaking Antineoplastic Nucleoside.

1992 • 23 citations

Development and biochemical characterization of a 2′-C-cyano-2′-deoxy-1-β-d-arabino-pentofuranosylcytosine (CNDAC)-resistant variant of the human fibrosarcoma cell line HT-1080

1998 • 13 citations

Isolation of Deoxycytidine Kinase from Ehrlich Carcinoma Cells by Affinity Chromatography Based on a Substrate Analog, 2'-C-Cyano-2'-deoxy-1-.BETA.-D-arabinofuranosyl-N4-palmitoylcytosine.

1999 • 4 citations