Heat Shock RNA Levels in Brain and Other Tissues After Hyperthermia and Transient Ischemia

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Statistical Principles in Experimental Design

1964 • 8,376 citations

Genomic sequencing.

1984 • 8,343 citations

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

New Tables for Multiple Comparisons with a Control

1964 • 3,084 citations

Heat shock, from bacteria to man

1982 • 1,260 citations

Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

1986 • 904 citations

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

1985 • 860 citations

Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85

1984 • 522 citations

Cellular and biochemical events in mammalian cells during and after recovery from physiological stress.

1986 • 513 citations

Localization of 70-kDa stress protein induction in gerbil brain after ischemia

1988 • 465 citations

Heat shock proteins: the search for functions.

1986 • 395 citations

Ubiquitin is a heat shock protein in chicken embryo fibroblasts.

1985 • 392 citations

The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences.

1985 • 355 citations

The yeast ubiquitin gene: head-to-tail repeats encoding a polyubiquitin precursor protein

1984 • 313 citations

Cell Surface Molecule Associated with Lymphocyte Homing Is a Ubiquitinated Branched-Chain Glycoprotein

1986 • 312 citations

Regulation of protein synthesis in HeLa cells: Translation at elevated temperatures

1969 • 302 citations

The ubiquitin system: functions and mechanisms

1985 • 298 citations

A comparative study of the role of the cerebral arterial blood in the regulation of brain temperature in five mammals

1969 • 272 citations

Synthesis of a Stress Protein Following Transient Ischemia in the Gerbil

1985 • 270 citations

Histone 2B can be modified by the attachment of ubiquitin

1980 • 245 citations

Trauma-Induced Protein in Rat Tissues: A Physiological Role for a "Heat Shock" Protein?

1981 • 233 citations

The ubiquitin‐mediated proteolytic pathway and mechanisms of energy‐dependent intracellular protein degradation

1984 • 221 citations

Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor.

1985 • 196 citations

Disappearance of a structural chromatin protein A24 in mitosis: implications for molecular basis of chromatin condensation.

1979 • 194 citations

Heat storage in running antelopes: independence of brain and body temperatures

1972 • 169 citations

Constitutively Expressed Rat mRNA Encoding a 70-Kilodalton Heat-Shock-Like Protein

1985 • 164 citations

The human ubiquitin gene family: structure of a gene and pseudogenes from the Ub B subfamily

1987 • 157 citations

Ischemia of the dog heart induces the appearance of a cardiac mRNA coding for a protein with migration characteristics similar to heat-shock/stress protein 71.

1986 • 153 citations

Selective induction of a heat shock gene in fibre tracts and cerebellar neurons of the rabbit brain detected by in situ hybridization

1987 • 145 citations

70‐Kilodalton Heat Shock Protein Induction in Cerebellar Astrocytes and Cerebellar Granule Cells In Vitro: Comparison with Immunocytochemical Localization After Hyperthermia In Vivo

1990 • 140 citations

The Chicken Ubiquitin Gene Contains a Heat Shock Promoter and Expresses an Unstable mRNA in Heat-Shocked Cells

1986 • 137 citations

Multiple ubiquitin mRNAs during xenopus laevis development contain tandem repeats of the 76 amino acid coding sequence

1984 • 130 citations

Synthesis of Heat Shock Proteins in Rat Brain Cortex after Transient Ischemia

1986 • 129 citations

Effects of ischemia and perfusion temperature on the synthesis of stress-induced (heart shock) proteins in isolated and perfused rat hearts*

1987 • 127 citations

Selective Gene Expression in Focal Cerebral Ischemia

1986 • 123 citations

Diverse forms of stress lead to new patterns of gene expression through a common and essential metabolic pathway.

1982 • 120 citations

Constitutively expressed rat mRNA encoding a 70-kilodalton heat-shock-like protein.

1985 • 104 citations

Protein Synthesis in Postischemic Rat Brain: A Two-Dimensional Electrophoretic Analysis

1986 • 99 citations

Heat shock protein in mammalian brain and other organs after a physiologically relevant increase in body temperature induced by D-lysergic acid diethylamide.

1983 • 98 citations

Impairment of protein ubiquitination may cause delayed neuronal death

1989 • 96 citations

The chicken ubiquitin gene contains a heat shock promoter and expresses an unstable mRNA in heat-shocked cells.

1986 • 94 citations

Synthesis of heat shock proteins in rat liver after ischemia and hyperthermia

1985 • 81 citations

Effect of 2450 MHz microwave energy on the blood-brain barrier to hydrophilic molecules. D. Brain temperature and blood-brain barrier permeability to hydrophilic tracers

1984 • 65 citations

Significance of cranial circulation for the brain homeothermia in rabbits. II. The role of the cranial venous lakes in the defence against hyperthermia.

1976 • 54 citations

Effects of Amphetamine on Protein Synthesis and Energy Metabolism in Mouse Brain: Role of Drug‐Induced Hyperthermia

1988 • 47 citations

Characterization of a Drosophila repeat mapping at the early-ecdysone puff 63F and present in many eucaryotic genomes

1984 • 33 citations

Isolation of a mouse heat-shock gene (hsp68) by recombinational screening

1987 • 33 citations

Disaggregation of brain polysomes after LSD in vivo

1979 • 32 citations

Expression of heat shock genes in fetal and maternal rabbit brain

1985 • 32 citations

An in vitro amino acid incorporation method for assessing the status of in vivo protein synthesis

1984 • 31 citations

Induction of mRNAs for heat shock proteins in livers of rats after ischemia and partial hepatectomy

1987 • 30 citations

Cell‐Free Translation of Free and Membrane‐Bound Polysomes and Polyadenylated mRNA from Rabbit Brain Following Administration of d‐Lysergic Acid Diethylamide In Vivo

1981 • 30 citations

Significance of cranial circulation for the brain homeothermia in rabbits. I. The brain-arterial blood temperature gradient.

1976 • 29 citations

Formation of conjugates by ¹²⁵I‐labelled ubiquitin microinjected into cultured hepatoma cells

1982 • 25 citations

Induction of Four Heat-Shock Proteins and Their mRNAs in Rat alter Whole-Body Hyperthermia1

1987 • 23 citations

Postnatal development of a cellular response to stress in rat brain

1983 • 13 citations