Alzheimer's disease: specific increases in a G protein subunit (GSα) mRNA in hippocampal and cortical neurons

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Glutamate neurotoxicity and diseases of the nervous system

1988 • 7,257 citations

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

ras GENES

1987 • 3,818 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

Basic Methods in Molecular Biology

1986 • 3,284 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

Receptor-effector coupling by G proteins

1990 • 1,117 citations

Alzheimer's Disease: X-Ray Spectrometric Evidence of Aluminum Accumulation in Neurofibrillary Tangle-Bearing Neurons

1980 • 995 citations

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Basic methods in molecular biology

1987 • 842 citations

Roles of G protein subunits in transmembrane signalling

1988 • 794 citations

Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.

1987 • 751 citations

A Neuronal Antigen in the Brains of Alzheimer Patients

1986 • 577 citations

Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites

1988 • 546 citations

Do GTPases direct membrane traffic in secretion?

1988 • 540 citations

Homologies Between Signal Transducing G Proteins and ras Gene Products

1984 • 500 citations

Biochemical Assessment of Serotonergic and Cholinergic Dysfunction and Cerebral Atrophy in Alzheimer's Disease

1983 • 440 citations

G0 is a major growth cone protein subject to regulation by GAP-43

1990 • 422 citations

Ionic Channels and Their Regulation by G Protein Subunits

1990 • 413 citations

G proteins control diverse pathways of transmembrane signaling ¹

1989 • 399 citations

Abnormal phosphorylation of the microtubule-associated protein? (tau) in Alzheimer cytoskeletal pathology

1987 • 393 citations

Isolation and characterization of the human Gs alpha gene.

1988 • 379 citations

Human cDNA clones for four species of G alpha s signal transduction protein.

1986 • 370 citations

Signal sorting and amplification through G protein-coupled receptors

1989 • 338 citations

Molecular basis for two forms of the G protein that stimulates adenylate cyclase.

1986 • 319 citations

Differential involvement of protein kinase C isozymes in Alzheimer's disease

1990 • 168 citations

Adrenergic Receptors in Aging and Alzheimer's Disease: Increased β₂‐Receptors in Prefrontal Cortex and Hippocampus

1989 • 162 citations

A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease

1987 • 161 citations

Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life.

1989 • 148 citations

Biochemical characterization of three stimulatory GTP-binding proteins. The large and small forms of Gs and the olfactory-specific G-protein, Golf.

1990 • 145 citations

Corticosterone differentially regulates the expression of Gs alpha and Gi alpha messenger RNA and protein in rat cerebral cortex.

1989 • 136 citations

Alzheimer's disease may begin in the nose and may be caused by aluminosilicates

1986 • 135 citations

Reduced binding of [3H]ketanserin to cortical 5-HT2 receptors in senile dementia of the Alzheimer type

1984 • 130 citations

Localization of mRNAs encoding the α‐subunits of signal‐transducing G‐proteins within rat brain and among peripheral tissues

1987 • 130 citations

Transphosphorylation and G protein activation

1990 • 125 citations

Alzheimer's disease and related disorders

1990 • 125 citations

Alternative promoter and 5' exon generate a novel Gs alpha mRNA.

1990 • 114 citations

Beyond receptors: Multiple second‐messenger systems in brain

1987 • 108 citations

Platelet membrane fluidity in Alzheimer's disease and major depression

1987 • 106 citations

Distribution of messenger RNAs encoding the enzymes glutaminase, aspartate aminotransferase and glutamic acid decarboxylase in rat brain

1990 • 94 citations

Abnormal processing of multiple proteins in Alzheimer disease.

1989 • 89 citations

G protein mRNA mapped in rat brain by in situ hybridization.

1988 • 86 citations

The G protein-channel connection

1990 • 85 citations

Altered expression of α-subunits of G proteins in failing human hearts

1989 • 80 citations

Terminal coma affects messenger RNA detection in post mortem human temporal cortex

1991 • 72 citations

Changes in β‐Adrenergic Receptor Subtypes in Alzheimer‐Type Dementia

1987 • 65 citations

Guanine nucleotide modulation of muscarinic cholinergic receptor binding in postmortem human brain — A preliminary study in Alzheimer's disease

1987 • 64 citations

In situ hybridization histochemistry and the study of gene expression in the human brain

1990 • 62 citations

Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease

1990 • 59 citations

Phosphorylation of rat brain cytoskeletal proteins is increased after orally administered aluminum

1988 • 56 citations

A neurite outgrowth-promoting molecule in developing fiber tracts

1988 • 55 citations

Increased muscarinic receptor messenger RNA in Alzheimer's disease temporal cortex demonstrated by in situ hybridization histochemistry

1991 • 53 citations

Alzheimer's disease: is there a problem beyond recognition?

1990 • 50 citations

D1-Dopamine Receptor Abnormality in Frontal Cortex Points to a Functional Alteration of Cortical Cell Membranes in Alzheimer's Disease

1990 • 49 citations

VIP-sensitive adenylate cyclase, guanylate cyclase, muscarinic receptors, choline acetyltransferase and acetylcholinesterase, in brain tissue afflicted by alzheimer's disease/senile dementia of the Alzheimer type

1988 • 48 citations

Regional and neuronal reductions of polyadenylated messenger RNA in Alzheimer's disease

1991 • 42 citations

Increased tau messenger RNA in Alzheimer's disease hippocampus.

1990 • 42 citations

Presence of neuropeptide messenger RNAs in neuronal processes

1990 • 38 citations

Multiple GTP-binding proteins from cholinergic synaptic vesicles

1990 • 36 citations

Reduced cAMP-signal transduction in postmortem hippocampus of demented old people.

1989 • 21 citations

Regional distribution of the expression of a human stimulatory GTP-binding protein α-subunit in the human brain studied by in situ hybridization

1988 • 18 citations

The guanine nucleotide regulatory protein-coupled receptors for nucleosides, nucleotides, amino acids and amine neurotransmitters

1989 • 13 citations

Complete cDNA sequence of a human stimulatory GTP-bindlng protein alpha subunit

1988 • 11 citations

Neurotransmitter receptor interactions with G-proteins: A critical link in receptor response mechanisms

1988 • 5 citations