Impaired Endoplasmic Reticulum Stress Response in B-Lymphoblasts From Patients With Bipolar-I Disorder

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

2001 • 156,143 citations

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

2004 • 3,671 citations

Roles of CHOP/GADD153 in endoplasmic reticulum stress

2003 • 2,663 citations

Endoplasmic reticulum stress: cell life and death decisions

2005 • 2,197 citations

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

2003 • 1,979 citations

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

2002 • 1,031 citations

The endoplasmic reticulum: a multifunctional signaling organelle

2002 • 948 citations

From acute ER stress to physiological roles of the Unfolded Protein Response

2006 • 850 citations

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

2003 • 843 citations

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

2000 • 525 citations

Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response

2002 • 508 citations

The Mood‐Stabilizing Agents Lithium and Valproate RobustlIncrease the Levels of the Neuroprotective Protein bcl‐2 in the CNS

1999 • 495 citations

Long Term Lithium Treatment Suppresses p53 and Bax Expression but Increases Bcl-2 Expression

1999 • 470 citations

Differential Contributions of ATF6 and XBP1 to the Activation of Endoplasmic Reticulum Stress-Responsive cis-Acting Elements ERSE, UPRE and ERSE-II

2004 • 421 citations

CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism

2005 • 281 citations

Cellular Plasticity Cascades: Targets for the Development of Novel Therapeutics for Bipolar Disorder

2006 • 276 citations

Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder

2003 • 272 citations

Endoplasmic Reticulum Stress Induction of the Grp78/BiP Promoter: Activating Mechanisms Mediated by YY1 and Its Interactive Chromatin Modifiers

2005 • 214 citations

Signaling: cellular insights into the pathophysiology of bipolar disorder

2000 • 212 citations

Bipolar Disorder and Diabetes Mellitus: Epidemiology, Etiology, and Treatment Implications

2005 • 202 citations

Modulation of Synaptic Plasticity by Antimanic Agents: The Role of AMPA Glutamate Receptor Subunit 1 Synaptic Expression

2004 • 161 citations

High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder

1997 • 145 citations

ATP2A2 Mutations in Darier's Disease and Their Relationship to Neuropsychiatric Phenotypes

1999 • 143 citations

Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analyses

2006 • 131 citations

Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders

2005 • 123 citations

Bcl-2 and Bax Exert Opposing Effects on Ca2+ Signaling, Which Do Not Depend on Their Putative Pore-forming Region

2004 • 112 citations

Transient Cerebral Ischemia Activates Processing of xbp1 Messenger RNA Indicative of Endoplasmic Reticulum Stress

2003 • 107 citations

Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP78 and Bcl-2

2005 • 101 citations

Association of the putative susceptibility gene, transient receptor potential protein melastatin type 2, with bipolar disorder

2005 • 97 citations

Discordance of UPR signaling by ATF6 and Ire1p-XBP1 with levels of target transcripts

2004 • 90 citations

Chronic Lithium Treatment Attenuates Intracellular Calcium Mobilization

2004 • 86 citations

Role of intracellular calcium signaling in the pathophysiology and pharmacotherapy of bipolar disorder: current status

2004 • 83 citations

Elevated basal and thapsigargin-stimulated intracellular calcium of platelets and lymphocytes from bipolar affective disorder patients measured by a fluorometric microassay

1999 • 77 citations

XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells

2006 • 73 citations

Mechanisms of altered Ca2+ signalling in transformed lymphoblastoid cells from patients with bipolar disorder

2003 • 71 citations

The Unfolded Protein Response Regulates Glutamate Receptor Export from the Endoplasmic Reticulum

2004 • 69 citations

Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder

2001 • 63 citations

Functional polymorphisms of HSPA5: Possible association with bipolar disorder

2005 • 58 citations

Psychiatric disorders and mutations at the Wolfram syndrome locus

2000 • 54 citations

Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorder

2000 • 50 citations

Associated disturbances in calcium homeostasis and G protein–mediated cAMP signaling in bipolar I disorder

2000 • 39 citations

Bipolar disorder and variation at a common polymorphism (A1832G) within exon 8 of the Wolfram gene

2000 • 34 citations

Transient Cerebral Ischemia Activates Processing of xbp1 Messenger RNA Indicative of Endoplasmic Reticulum Stress

2003 • 30 citations

No association of mutations and mRNA expression of WFS1/wolframin with bipolar disorder in humans

2003 • 26 citations

Cerebral Signal Transduction: From First to Fourth Messengers

2000 • 25 citations

Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro

2005 • 24 citations

Signal Transduction Abnormalities in Bipolar Affective Disorder

2000 • 23 citations

Up-regulation of genes involved in cellular stress and apoptosis in a rat model of hippocampal degeneration

2000 • 22 citations

Growth arrest and DNA damage-inducible gene 153 increases transiently in the thalamus following focal cerebral infarction

2004 • 17 citations

Mefloquine-induced mania in a 22-year-old Chinese man.

2006 • 13 citations

Bipolar disorder after mefloquine treatment.

2001 • 13 citations

Regulation of molecular chaperone GRP78 by mood stabilizing drugs

2004 • 6 citations

Deleted Work

1955 • 0 citations