Placental development: Lessons from mouse mutants

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4

1998 • 3,360 citations

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

1993 • 2,370 citations

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

1999 • 1,904 citations

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

1995 • 1,457 citations

Promotion of Trophoblast Stem Cell Proliferation by FGF4

1998 • 1,340 citations

Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud

1995 • 1,278 citations

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

1995 • 1,039 citations

Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

1995 • 1,016 citations

Expression of a xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm induction

1991 • 980 citations

Regulation of Human Placental Development by Oxygen Tension

1997 • 905 citations

Requirement for LIml in head-organizer function

1995 • 801 citations

Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development

1995 • 792 citations

Embryonic stem cells alone are able to support fetal development in the mouse

1990 • 789 citations

Requirement of FGF-4 for Postimplantation Mouse Development

1995 • 743 citations

The molecular basis of lung morphogenesis

2000 • 729 citations

Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse

1992 • 676 citations

Homeosis and intestinal tumours in Cdx2 mutant mice

1997 • 670 citations

Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development

1998 • 618 citations

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3

2000 • 615 citations

Essential role of Mash-2 in extraembryonic development

1994 • 612 citations

Eomesodermin is required for mouse trophoblast development and mesoderm formation

2000 • 610 citations

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

1995 • 583 citations

Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction

1998 • 555 citations

Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice

1995 • 554 citations

HSF1 is required for extra-embryonic development, postnatal growth and protection during inflammatory responses in mice

1999 • 549 citations

The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis

1998 • 524 citations

Essential Role of p38α MAP Kinase in Placental but Not Embryonic Cardiovascular Development

2000 • 509 citations

Wnt3a-/--like phenotype and limb deficiency in Lef1-/-Tcf1-/- mice

1999 • 457 citations

Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree

1996 • 420 citations

Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-β

1997 • 414 citations

The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta

2000 • 408 citations

Direct protein–protein interaction between the intracellular domain of TRA-2 and the transcription factor TRA-1A modulates feminizing activity in C. elegans

2000 • 397 citations

Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation.

1995 • 393 citations

Mammalian Grb2 Regulates Multiple Steps in Embryonic Development and Malignant Transformation

1998 • 377 citations

Defective vascular development in connexin 45-deficient mice

2000 • 359 citations

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

1997 • 359 citations

Targeted disruption of the Wnt2 gene results in placentation defects

1996 • 357 citations

Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup

1999 • 343 citations

Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta

1999 • 337 citations

Molecular identification of spadetail: regulation of zebrafish trunk and tail mesoderm formation by T-box genes

1998 • 333 citations

ARNT-Deficient Mice and Placental Differentiation

1997 • 331 citations

Interaction between FGF and BMP signaling pathways regulates development of metanephric mesenchyme

1999 • 314 citations

Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis

2001 • 313 citations

Defective trophoblast function in mice with a targeted mutation of Ets2

1998 • 299 citations

Transplacental Uptake of Glucose Is Decreased in Embryonic Lethal Connexin26-deficient Mice

1998 • 280 citations

Reprogramming of intestinal differentiation and intercalary regeneration inCdx2mutant mice

1999 • 273 citations

Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta

2002 • 270 citations

Mice lacking HSP90β fail to develop a placental labyrinth

2000 • 269 citations

Genetic insights into trophoblast differentiation and placental morphogenesis

2000 • 264 citations

Origin of the ectoplacental cone and secondary giant cells in mouse blastocysts reconstituted from isolated trophoblast and inner cell mass

1973 • 262 citations

JunB is essential for mammalian placentation

1999 • 261 citations

Role of Gab1 in Heart, Placenta, and Skin Development and Growth Factor- and Cytokine-Induced Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Activation

2000 • 258 citations

Placental failure in mice lacking the homeobox gene Dlx 3

1999 • 256 citations

Expression of Vascular Endothelial Growth Factor and Placenta Growth Factor in Human Placenta1

1997 • 254 citations

Diethylstilbestrol regulates trophoblast stem cell differentiation as a ligand of orphan nuclear receptor ERRβ

2001 • 253 citations

Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors

1998 • 246 citations

Mekk3 is essential for early embryonic cardiovascular development

2000 • 243 citations

Esx1 is an X-chromosome-imprinted regulator of placental development and fetal growth

1998 • 227 citations

Mash2 Acts Cell Autonomously in Mouse Spongiotrophoblast Development

1997 • 219 citations

Fgfr2 is required for limb outgrowth and lung-branching morphogenesis

1999 • 208 citations

Reprogramming the Cell Cycle for Endoreduplication in Rodent Trophoblast Cells

1998 • 201 citations

Mesodermal defects and cranial neural crest apoptosis in α5 integrin-null embryos

1997 • 193 citations

Placental Failure in Mice Lacking the Mammalian Homolog of Glial Cells Missing, GCMa

2000 • 192 citations

Regulation of Hox gene expression and posterior development by the Xenopus caudal homologue Xcad3

1998 • 190 citations

Genes governing placental development

2001 • 189 citations

Interaction between inner cell mass and trophectoderm of the mouse blastocyst : II. The fate of the polar trophectoderm

1979 • 185 citations

Expression and function of FGF-4 in peri-implantation development in mouse embryos

1994 • 180 citations

The bHLH-Zip transcription factor Tfeb is essential for placental vascularization

1998 • 179 citations

Retinoid X receptors are essential for early mouse development and placentogenesis

1999 • 176 citations

Branching morphogenesis of embryonic mouse lung epithelium in mesenchyme-free culture

1995 • 167 citations

Villous sprouting: fundamental mechanisms of human placental development

2000 • 162 citations

Polytene Chromosomes in Mammalian Cells

1996 • 155 citations

Expression of the T-box gene Eomesodermin during early mouse development

1999 • 153 citations

Placental vascularisation requires the AP-1 component Fra1

2000 • 152 citations

MurineGcm1 gene is expressed in a subset of placental trophoblast cells

1999 • 147 citations

Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis

1996 • 137 citations

Differentiation of trophoblast endocrine cells

1996 • 133 citations

Inactivation of the FGF-4 Gene in Embryonic Stem Cells Alters the Growth and/or the Survival of Their Early Differentiated Progeny

1997 • 128 citations

FGF Is an Essential Regulator of the Fifth Cell Division in Preimplantation Mouse Embryos

1998 • 126 citations

PDGFB Regulates the Development of the Labyrinthine Layer of the Mouse Fetal Placenta

1999 • 124 citations

Oxygen, genes, and development: An analysis of the role of hypoxic gene regulation during murine vascular development

1998 • 124 citations

A cell autonomous function of Brachyury in T/T embryonic stem cell chimaeras

1991 • 117 citations

Regulatory molecules in kidney development

2000 • 115 citations

Early pregnancy wastage: relationship between chorionic vascularization and embryonic development

1988 • 115 citations

Esx1,a Novel X Chromosome-Linked Homeobox Gene Expressed in Mouse Extraembryonic Tissues and Male Germ Cells

1997 • 110 citations

Requirement of the mouseI-mfagene for placental development and skeletal patterning

1998 • 110 citations

A repertoire of differentially expressed transcription factors that offers insight into mechanisms of human cytotrophoblast differentiation

1999 • 110 citations

The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties

2000 • 109 citations

Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development

1999 • 108 citations

Retinoic Acid Promotes Differentiation of Trophoblast Stem Cells to a Giant Cell Fate

2001 • 95 citations

Properties of extra-embryonic ectoderm isolated from postimplantation mouse embryos

1977 • 92 citations

Expression of Fgfr2 in the early mouse embryo indicates its involvement in preimplantation development

1999 • 91 citations

Placenta Growth Factor and Vascular Endothelial Growth Factor are Co-Expressed During Early Embryonic Development

1997 • 82 citations

The Human Achaete-Scute Homologue 2 (ASCL2, HASH2) Maps to Chromosome 11p15.5, Close to IGF2 and is Expressed in Extravillus Trophoblasts

1997 • 79 citations

Proliferin Induces Endothelial Cell Chemotaxis through a G Protein-Coupled, Mitogen-Activated Protein Kinase-Dependent Pathway*

1997 • 76 citations

Effect of culture conditions on diploid to giant-cell transformation in postimplantation mouse trophoblast

1981 • 71 citations

Placental Expression and Chromosomal Localization of the Human Gcm 1 Gene

2000 • 63 citations

Morphogenesis of the syncytium in the mouse placenta

1974 • 62 citations

Ontogeny of Hepatocyte Growth Factor (HGF) and Its Receptor (c-met) in Human Placenta

1998 • 60 citations

Molecular cloning of the human Hand1 gene/cDNA and its tissue-restricted expression in cytotrophoblastic cells and heart

1998 • 57 citations

Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis

2001 • 55 citations

Expression of matrix metalloproteinases during murine chorioallantoic placenta maturation

1999 • 50 citations

Placental findings in spontaneous abortions and stillbirths

1981 • 49 citations

Expression of fibroblast growth factor receptors in peri-implantation mouse embryos

1998 • 48 citations

Expression and function of the urokinase type plasminogen activator during mouse hemochorial placental development

1998 • 46 citations

Molecular studies on cells of the trophectodermal lineage of the postimplantation mouse embryo

1981 • 43 citations

On the control of the trophoblastic giant-cell transformation in the mouse: homotypic cellular interactions and polyploidy

1981 • 43 citations

DNA ploidy of hydatidiform moles and nonmolar conceptuses: a study using flow and tissue section image cytometry.

1995 • 41 citations

Differential susceptibility of mouse trophoblast and embryonic tissue to immune cell lysis.

1974 • 40 citations

DIFFERENTIAL SUSCEPTIBILITY OF MOUSE TROPHOBLAST AND EMBRYONIC TISSUE TO IMMUNE CELL LYSIS

1974 • 40 citations

Trophoblast function in normal and preeclamptic pregnancy

1996 • 36 citations

Expression and function of the urokinase type plasminogen activator during mouse hemochorial placental development

1998 • 34 citations

Essential Role of Platelet-Derived Growth Factor Receptor α in the Development of the Intraplacental Yolk Sac/Sinus of Duval in Mouse Placenta1

1998 • 31 citations

Comparison of histological features in early spontaneous and induced trisomic abortions

1994 • 26 citations

Morphogenesis: FGF branches out

1997 • 22 citations

The development and proliferation of the trophoblast from ectopic mouse embryo allografts of increasing gestational age

1976 • 11 citations