Genetic insights into trophoblast differentiation and placental morphogenesis

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4

1998 • 3,360 citations

Purification, Characterization, andin vitroDifferentiation of Cytotrophoblasts from Human Term Placentae*

1986 • 1,556 citations

Marshall’s Physiology of Reproduction

1994 • 1,461 citations

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

1995 • 1,457 citations

Implantation and the placenta: key pieces of the development puzzle

1994 • 1,362 citations

Promotion of Trophoblast Stem Cell Proliferation by FGF4

1998 • 1,340 citations

Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor

1995 • 1,039 citations

Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor

1995 • 1,016 citations

Requirement for LIml in head-organizer function

1995 • 801 citations

Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development

1995 • 792 citations

Requirement of FGF-4 for Postimplantation Mouse Development

1995 • 743 citations

Oct-4 Transcription Factor Is Differentially Expressed in the Mouse Embryo during Establishment of the First Two Extraembryonic Cell Lineages Involved in Implantation

1994 • 623 citations

Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development

1998 • 618 citations

Essential role of Mash-2 in extraembryonic development

1994 • 612 citations

Experimental Approaches to Mammalian Embryonic Development

1987 • 596 citations

Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction

1998 • 555 citations

Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice

1995 • 554 citations

Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.

1993 • 534 citations

The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis

1998 • 524 citations

Adhesive and degradative properties of human placental cytotrophoblast cells in vitro.

1989 • 477 citations

Interplay between proliferation and differentiation within the myogenic lineage

1992 • 424 citations

Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree

1996 • 420 citations

Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-β

1997 • 414 citations

Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation.

1995 • 393 citations

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

1997 • 359 citations

Targeted disruption of the Wnt2 gene results in placentation defects

1996 • 357 citations

B-Lymphocyte Development Is Regulated by the Combined Dosage of Three Basic Helix-Loop-Helix Genes, E2A, E2-2, and HEB†

1996 • 339 citations

ARNT-Deficient Mice and Placental Differentiation

1997 • 331 citations

Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development

1995 • 321 citations

JunB is essential for mammalian placentation

1999 • 261 citations

Placental failure in mice lacking the homeobox gene Dlx 3

1999 • 256 citations

Stimulation and inhibition of angiogenesis by placental proliferin and proliferin-related protein

1994 • 244 citations

Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix–loop–helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells

1997 • 236 citations

Esx1 is an X-chromosome-imprinted regulator of placental development and fetal growth

1998 • 227 citations

Mash2 Acts Cell Autonomously in Mouse Spongiotrophoblast Development

1997 • 219 citations

Each member of the Id gene family exhibits a unique expression pattern in mouse gastrulation and neurogenesis

1997 • 213 citations

Interaction between inner cell mass and trophectoderm of the mouse blastocyst:I. A study of cellular proliferation

1978 • 196 citations

Interaction between inner cell mass and trophectoderm of the mouse blastocyst : II. The fate of the polar trophectoderm

1979 • 185 citations

Polytene Chromosomes in Mammalian Cells

1996 • 155 citations

DNA binding and transcriptional regulatory activity of mammalian achaete-scute homologous (MASH) proteins revealed by interaction with a muscle-specific enhancer.

1992 • 152 citations

MurineGcm1 gene is expressed in a subset of placental trophoblast cells

1999 • 147 citations

The Uteroplacental Prolactin Family and Pregnancy1

1998 • 143 citations

The Development of Normal and Homozygous Brachy (T/T) Mouse Embryos in the Extraembryonic Coelom of the Chick

1944 • 134 citations

Progressive expression of trophoblast‐specific genes during formation of mouse trophoblast giant cells in vitro

1993 • 125 citations

Molecular genetics of implantation in the mouse

1997 • 123 citations

Early pregnancy wastage: relationship between chorionic vascularization and embryonic development

1988 • 115 citations

The Transition to Endoreduplication in Trophoblast Giant Cells Is Regulated by the mSNA Zinc Finger Transcription Factor

1998 • 115 citations

Esx1,a Novel X Chromosome-Linked Homeobox Gene Expressed in Mouse Extraembryonic Tissues and Male Germ Cells

1997 • 110 citations

Requirement of the mouseI-mfagene for placental development and skeletal patterning

1998 • 110 citations

A repertoire of differentially expressed transcription factors that offers insight into mechanisms of human cytotrophoblast differentiation

1999 • 110 citations

Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development

1999 • 108 citations

In vitro cultured human term cytotrophoblast: A model for normal primary epithelial cells demonstrating a spontaneous differentiation programme that requires EGF for extensive development of syncytium

1997 • 104 citations

Properties of extra-embryonic ectoderm isolated from postimplantation mouse embryos

1977 • 92 citations

Uterine Natural Killer Cells Are Targets for a Trophoblast Cell-Specific Cytokine, Prolactin-Like Protein A*

1999 • 89 citations

Placenta Growth Factor and Vascular Endothelial Growth Factor are Co-Expressed During Early Embryonic Development

1997 • 82 citations

The Human Achaete-Scute Homologue 2 (ASCL2, HASH2) Maps to Chromosome 11p15.5, Close to IGF2 and is Expressed in Extravillus Trophoblasts

1997 • 79 citations

Differential expression of the TEF family of transcription factors in the murine placenta and during differentiation of primary human trophoblasts in vitro

1998 • 73 citations

Developmental restriction ofMash-2 expression in trophoblast correlates with potential activation of the Notch-2 pathway

1997 • 71 citations

Effect of culture conditions on diploid to giant-cell transformation in postimplantation mouse trophoblast

1981 • 71 citations

Expression of Adrenomedullin, a Hypotensive Peptide, in the Trophoblast Giant Cells at the Embryo Implantation Site in Mouse

1998 • 70 citations

Potency, lineage, and allocation in preimplantation mouse embryos

1987 • 66 citations

Functional gene cassettes in development.

1993 • 59 citations

Molecular cloning of the human Hand1 gene/cDNA and its tissue-restricted expression in cytotrophoblastic cells and heart

1998 • 57 citations

Placental findings in spontaneous abortions and stillbirths

1981 • 49 citations

1 The Murine Allantois

1998 • 47 citations

DNA ploidy of hydatidiform moles and nonmolar conceptuses: a study using flow and tissue section image cytometry.

1995 • 41 citations

Trophoblast function in normal and preeclamptic pregnancy

1996 • 36 citations

Comparison of histological features in early spontaneous and induced trisomic abortions

1994 • 26 citations

Art for the anthropologist

1990 • 2 citations