Gap junctional complexes: From partners to functions
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References (231)
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The Coiled-coil Domain of Occludin Can Act to Organize Structural and Functional Elements of the Epithelial Tight Junction
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Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression
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Drebrin Is a Novel Connexin-43 Binding Partner that Links Gap Junctions to the Submembrane Cytoskeleton
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Formation of heteromeric gap junction channels by connexins 40 and 43 in vascular smooth muscle cells
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trans-dominant inhibition of connexin-43 by mutant connexin-26: implications for dominant connexin disorders affecting epidermal differentiation
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Ser364 of connexin43 and the upregulation of gap junction assembly by cAMP
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Pannexin1 is expressed by neurons and glia but does not form functional gap junctions
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Interaction of c-Src with Gap Junction Protein Connexin-43
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Untitled
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Connexin43 and Connexin45 Form Heteromeric Gap Junction Channels in Which Individual Components Determine Permeability and Regulation
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Gap-junction disassembly and connexin 43 dephosphorylation induced by 18β-glycyrrhetinic acid
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Differential regulation of distinct types of gap junction channels by similar phosphorylating conditions.
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Four Classes of Intercellular Channels between Glial Cells in the CNS
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Gap junction- and hemichannel-independent actions of connexins
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Epidermal growth factor regulates ubiquitination, internalization and proteasome-dependent degradation of connexin43
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Multiple pathways in the trafficking and assembly of connexin 26, 32 and 43 into gap junction intercellular communication channels
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Functional analysis of human cardiac gap junction channel mutants.
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Ubiquitination and Down-regulation of Gap Junction Protein Connexin-43 in Response to 12-O-Tetradecanoylphorbol 13-Acetate Treatment
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Dissection of the Molecular Basis of pp60v-src Induced Gating of Connexin 43 Gap Junction Channels
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CCN3 (NOV) Interacts with Connexin43 in C6 Glioma Cells
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Connexin-43 Interactions with ZO-1 and α- and β-tubulin
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Connexin43 Interacts with NOV
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Connexin45 directly binds to ZO‐1 and localizes to the tight junction region in epithelial MDCK cells
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Hetero-Domain Interactions as a Mechanism for the Regulation of Connexin Channels
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Role of the Carboxyl Terminal of Connexin43 in Transjunctional Fast Voltage Gating
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Cochlear gap junctions coassembled from Cx26 and 30 show faster intercellular Ca2+ signaling than homomeric counterparts
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Normalization of nomenclature for peptide motifs as ligands of modular protein domains
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Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process
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Defective Epidermal Barrier in Neonatal Mice Lacking the C-Terminal Region of Connexin43
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Spatiotemporal Development and Distribution of Intercellular Junctions in Adult Rat Cardiomyocytes in Culture
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Formation of the gap junction nexus: binding partners for connexins
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Connexin 43 Interacts with Zona Occludens-1 and -2 Proteins in a Cell Cycle Stage-specific Manner
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Connexin-specific distribution within gap junctions revealed in living cells
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Regulation of Connexin43 Protein Complexes by Intracellular Acidification
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Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and cx47 association with zonula occludens-1 (zo-1) in mouse brain
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N-cadherin-Catenin Complexes Form Prior to Cleavage of the Proregion and Transport to the Plasma Membrane
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Expression of chimeric connexins reveals new properties of the formation and gating behavior of gap junction channels
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Connexin 32 of gap junctions contains two cytoplasmic calmodulin-binding domains
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Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node
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Calmodulin Directly Gates Gap Junction Channels
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Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes
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Connexins as targets for cancer chemoprevention and chemotherapy
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Functional consequences of heterogeneous gap junction channel formation and its influence in health and disease
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Gap junction channel gating modulated through protein phosphorylation
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Disruption of gap junctional intercellular communication by lindane is associated with aberrant localization of connexin43 and zonula occludens-1 in 42GPA9 Sertoli cells
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Cx32 but Not Cx26 Is Associated with Tight Junctions in Primary Cultures of Rat Hepatocytes
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Lens Connexins α3Cx46 and α8Cx50 Interact with Zonula Occludens Protein-1 (ZO-1)
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Expression of zonula occludens‐1 (ZO‐1) and the transcription factor ZO‐1‐associated nucleic acid‐binding protein (ZONAB)–MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain
2005 • 106 citations
Electrical conductance of mouse connexin45 gap junction channels is modulated by phosphorylation
2000 • 106 citations
Internalization of the Kv1.4 Potassium Channel Is Suppressed by Clustering Interactions with PSD-95
2000 • 106 citations
Connexin43 phosphorylation state and intercellular communication in cultured astrocytes following hypoxia and protein phosphatase inhibition
2000 • 103 citations
Connexin45 Interacts with Zonula Occludens-1 and Connexin43 in Osteoblastic Cells
2001 • 101 citations
Heterotypic gap junction channel formation between heteromeric and homomeric Cx40 and Cx43 connexons
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Expression and function of connexins in the epidermis, analyzed with transgenic mouse mutants
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Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2
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Ubiquitylation of Ion Channels
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Regulation of gap junctions by tyrosine protein kinases
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A Particle-Receptor Model for the Insulin-Induced Closure of Connexin43 Channels
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Assembly of heteromeric connexons in guinea‐pig liver en route to the Golgi apparatus, plasma membrane and gap junctions
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ZO-1 alters the plasma membrane localization and function of Cx43 in osteoblastic cells
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Protein Kinase Cγ Regulation of Gap Junction Activity through Caveolin-1–Containing Lipid Rafts
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A Pharmacological Approach to the Structure of Sodium Channels in Myelinated Axons
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The Carboxyl Terminal Domain Regulates the Unitary Conductance and Voltage Dependence of Connexin40 Gap Junction Channels
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Sphingosine 1-Phosphate Induces Myoblast Differentiation through Cx43 Protein Expression: A Role for a Gap Junction-dependent and -independent Function
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Induction of Tight Junctions in Human Connexin 32 (hCx32)-Transfected Mouse Hepatocytes: Connexin 32 Interacts with Occludin
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Gap Junction Channel Protein Innexin 2 Is Essential for Epithelial Morphogenesis in theDrosophilaEmbryo
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Inhibition of gap junction communication in alveolar epithelial cells by 18α-glycyrrhetinic acid
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Functional Domain Mapping and Selective Trans-dominant Effects Exhibited by Cx26 Disease-causing Mutations
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Molecular Dissection of Transjunctional Voltage Dependence in the Connexin-32 and Connexin-43 Junctions
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Is calmodulin involved in the regulation of gap junction permeability?
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Gap Junction Formation between Cultured Embryonic Lens Cells Is Inhibited by Antibody to N-Cadherin
1996 • 83 citations
Gap Junctions Assemble in the Presence of Cytoskeletal Inhibitors, but Enhanced Assembly Requires Microtubules
2002 • 81 citations
A tyrosine-based sorting signal is involved in connexin43 stability and gap junction turnover
2003 • 81 citations
Role of catenins in the development of gap junctions in rat cardiomyocytes
2003 • 80 citations
Functional Role of c-Src in Gap Junctions of the Cardiomyopathic Heart
1999 • 80 citations
Fusion of GFP to the Carboxyl Terminus of Connexin43 Increases Gap Junction Size in HeLa Cells
2003 • 80 citations
Rho and Rho-kinase (ROCK) signaling in adherens and gap junction assembly in corneal epithelium.
2002 • 78 citations
Impaired Trafficking of Connexins in Androgen-independent Human Prostate Cancer Cell Lines and Its Mitigation by α-Catenin
2002 • 78 citations
Molecular Cloning, Functional Expression, and Tissue Distribution of a Novel Human Gap Junction-forming Protein, Connexin-31.9
2002 • 77 citations
Micro-domains of AQP0 in Lens Equatorial Fibers
2002 • 75 citations
Connexin40 and connexin43 in mouse aortic endothelium: evidence for coordinated regulation
2005 • 75 citations
Cx32 Formation and/or Cx32-Mediated Intercellular Communication Induces Expression and Function of Tight Junctions in Hepatocytic Cell Line
2002 • 74 citations
Regulation of Connexin43-Protein Binding in Astrocytes in Response to Chemical Ischemia/Hypoxia
2004 • 72 citations
Microinjected Anti-actin Antibodies Decrease Gap Junctional Intercellular Commmunication in Cultured Astrocytes
2002 • 72 citations
Heteromeric, but Not Homomeric, Connexin Channels Are Selectively Permeable to Inositol Phosphates
2006 • 71 citations
Protein Kinase C- α and - ϵ Modulate Connexin-43 Phosphorylation in Human Heart
2001 • 71 citations
Developmental expression and assembly of connexins into homomeric and heteromeric gap junction hemichannels in the mouse mammary gland
2000 • 70 citations
Modifications in the Biophysical Properties of Connexin43 Channels by a Peptide of the Cytoplasmic Loop Region
2004 • 68 citations
High-resolution proteomic mapping in the vertebrate central nervous system: Close proximity of connexin35 to NMDA glutamate receptor clusters and co-localization of connexin36 with immunoreactivity for zonula occludens protein-1 (ZO-1)
2004 • 68 citations
Interaction of calmodulin and other calcium-modulated proteins with mammalian and arthropod junctional membrane proteins
1985 • 68 citations
Connexin-Occludin Chimeras Containing the Zo-Binding Domain of Occludin Localize at Mdck Tight Junctions and Nrk Cell Contacts
1999 • 67 citations
The Gap Junction Protein Connexin32 Interacts with the Src Homology 3/Hook Domain of Discs Large Homolog 1
2007 • 66 citations
Occludin binds to the SH3-hinge-GuK unit of zonula occludens protein 1: potential mechanism of tight junction regulation
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Assembly of gap junction channels
2001 • 65 citations
Immunolocalization and expression of functional and nonfunctional cell-to-cell channels from wild-type and mutant rat heart connexin43 cDNA.
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Altered permeability and modulatory character of connexin channels during mammary gland development
2004 • 64 citations
A proposed role for ZO-1 in targeting connexin 43 gap junctions to the endocytic pathway
2004 • 64 citations
Control of Intracellular Movement of Connexins by E-Cadherin in Murine Skin Papilloma Cells
2001 • 63 citations
Developmental Regulation of the Direct Interaction between the Intracellular Loop of Connexin 45.6 and the C Terminus of Major Intrinsic Protein (Aquaporin-0)
2005 • 62 citations
Multiple Connexins Form Gap Junction Channels in Rat Basilar Artery Smooth Muscle Cells
1999 • 60 citations
Disruption of Gap Junctional Communication by the Platelet-derived Growth Factor Is Mediated via Multiple Signaling Pathways
1999 • 60 citations
pH-Dependent Dimerization of the Carboxyl Terminal Domain of Cx43
2004 • 60 citations
Dominant cataracts result from incongruous mixing of wild-type lens connexins
2003 • 60 citations
Altered Dye Diffusion and Upregulation of Connexin37 in Mouse Aortic Endothelium Deficient in Connexin40
2002 • 57 citations
Mitogen-activated protein kinase and phosphorylation of connexin43 are not sufficient for the disruption of gap junctional communication by platelet-derived growth factor and tetradecanoylphorbol acetate
1999 • 56 citations
Novel Rab GAP-like Protein, CIP85, Interacts with Connexin43 and Induces Its Degradation
2005 • 56 citations
Association of connexin36 with zonula occludens-1 in HeLa cells, ?TC-3 cells, pancreas, and adrenal gland
2000 • 54 citations
Identification of Connexin-43 Interacting Proteins
2003 • 53 citations
Ligand Binding of the Second PDZ Domain Regulates Clustering of PSD-95 with the Kv1.4 Potassium Channel
2002 • 52 citations
Calcium-dependent binding of calmodulin to neuronal gap junction proteins
2005 • 51 citations
In vivo association of pp60v-src and the gap-junction protein connexin 43 in v-src-transformed fibroblasts
1999 • 50 citations
Role of Cytoskeletal Elements in the Recruitment of Cx43-GFP and Cx26-YFP into Gap Junctions
2001 • 50 citations
Modulation of intercellular communication in macrophages: possible interactions between GAP junctions and P2 receptors
2004 • 50 citations
Cardiac Connexins: Genes to Nexus
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The cochlear F-box protein OCP1 associates with OCP2 and connexin 26
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ATP counteracts the rundown of gap junctional channels of rat ventricular myocytes by promoting protein phosphorylation
1999 • 48 citations
A 17mer Peptide Interferes With Acidification-Induced Uncoupling of Connexin43
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Association of connexin36 and zonula occludens-1 with zonula occludens-2 and the transcription factor zonula occludens-1-associated nucleic acid-binding protein at neuronal gap junctions in rodent retina
2006 • 48 citations
Electrophysiological properties of gap junction channels in hepatocytes isolated from connexin32-deficient and wild-type mice
1999 • 48 citations
Connexins, innexins and pannexins: Bridging the communication gap
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An inhibition of gap-junctional communication by cadherins
1997 • 43 citations
Ischemia Impairs the Association Between Connexin 43 and M3 Subtype of Acetylcholine Muscarinic Receptor (M3-mAChR) in Ventricular Myocytes
2006 • 41 citations
Effects of peroxisome proliferators and 12-O-tetradecanoyl phorbol-13-acetate on intercellular communication and connexin43 in two hamster fibroblast systems
1997 • 40 citations
Dephosphorylation agents depress gap junctional communication between rat cardiac cells without modifying the Connexin43 phosphorylation degree.
2000 • 38 citations
Regulation of Lens Cell-to-Cell Communication by Activation of PKCγ and Disassembly of Cx50 Channels
2005 • 37 citations
Down-Regulation of Gap Junctional Intercellular Communication Between Osteoblastic MC3T3-E1 Cells by Basic Fibroblast Growth Factor and a Phorbol Ester (12-O-Tetradecanoylphorbol-13-Acetate)
1997 • 37 citations
Knock-in of α3 connexin prevents severe cataracts caused by an α8 point mutation
2006 • 36 citations
Characterization of the Association of Connexins and ZO-1 in the Lens
2001 • 35 citations
Targeting motifs and functional parameters governing the assembly of connexins into gap junctions
2000 • 32 citations
Protein phosphatase modulation of the intercellular junctional communication: Importance in cardiac myocytes
2005 • 32 citations
Dynamics of astrocyte adhesion as analyzed by a combination of atomic force microscopy and immunocytochemistry. The involvement of actin filaments and connexin 43 in the early stage of adhesion.
1999 • 32 citations
Localization and distribution of gap junctions in normal and cardiomyopathic hamster heart
1994 • 32 citations
Expression and regulation of connexins in cultured ventricular myocytes isolated from adult rat hearts
2002 • 30 citations
Molecular modeling and mutagenesis of gap junction channels
2007 • 30 citations
Deficient epithelial-fibroblast heterocellular gap junction communication can be overcome by co-culture with an intermediate cell type but not by E-cadherin transgene expression
1998 • 30 citations
Connexin43 PDZ2 Binding Domain Mutants Create Functional Gap Junctions and Exhibit Altered Phosphorylation
2004 • 29 citations
Association of Connexin43 with a Receptor Protein Tyrosine Phosphatase
2003 • 28 citations
E‐CADHERIN EXPRESSION CAN ALTER THE SPECIFICITY OF GAP JUNCTION FORMATION
1997 • 28 citations
Association with ZO-1 Correlates with Plasma Membrane Partitioning in Truncated Connexin45 Mutants
2005 • 26 citations
Connexin 26 expression prevents down-regulation of barrier and fence functions of tight junctions by Na+/K+-ATPase inhibitor ouabain in human airway epithelial cell line Calu-3
2006 • 25 citations
Role of intramolecular interaction in connexin50: Mediating the Ca2+-dependent binding of calmodulin to gap junction
2005 • 25 citations
Molecular cloning and functional analysis of a novel Cx43 partner protein CIP150
2005 • 25 citations
Hsu M, Andl T, Li G, Meinkoth JL, Herlyn MCadherin repertoire determines partner-specific gap junctional communication during melanoma progression. J Cell Sci 113: 1535-1542
2000 • 25 citations
Peptides acting at gap junctions
2002 • 24 citations
Identification of a Potential Regulator of the Gap Junction Protein Pannexin1
2005 • 23 citations
Connexin45 Interacts with Zonula Occludens-1 in Osteoblastic Cells
2001 • 22 citations
Is the junctional uncoupling elicited in rat ventricular myocytes by some dephosphorylation treatments due to changes in the phosphorylation status of Cx43?
2004 • 17 citations
Targeting motifs and functional parameters governing the assembly of connexins into gap junctions
2000 • 14 citations
Myotonic dystrophy protein kinase of the cardiac muscle: Evaluation using an immunochemical approach
2002 • 11 citations
Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and cx47 association with zonula occludens-1 (zo-1) in mouse brain
2004 • 5 citations