A Pharmacological Approach to the Structure of Sodium Channels in Myelinated Axons

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Ionic Blockage of Sodium Channels in Nerve

1973 • 1,590 citations

Tetrodotoxin Blockage of Sodium Conductance Increase in Lobster Giant Axons

1964 • 1,065 citations

A theory of the effects of fibre size in medullated nerve

1951 • 1,036 citations

The Permeability of the Sodium Channel to Organic Cations in Myelinated Nerve

1971 • 751 citations

The action potential in the myelinated nerve fibre of Xenopus laevis as computed on the basis of voltage clamp data

1964 • 694 citations

The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

1973 • 660 citations

Electrochemical aspects of physiological and pharmacological action in excitable cells. I. The resting cell and its alteration by extrinsic factors.

1958 • 579 citations

Kinetics and steady‐state properties of the charged system controlling sodium conductance in the squid giant axon

1974 • 420 citations

Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.

1975 • 387 citations

The binding of saxitoxin and tetrodotoxin to excitable tissue

1977 • 369 citations

The receptor for tetrodotoxin and saxitoxin. A structural hypothesis

1975 • 295 citations

Intramembranous particle distribution at the node of Ranvier and adjacent axolemma in myelinated axons of the frog brain

1976 • 260 citations

Local anesthetics. Effect of pH on use-dependent block of sodium channels in frog muscle

1977 • 256 citations

The binding of labelled tetrodotoxin to non‐myelinated nerve fibres

1972 • 206 citations

Inhibition of sodium currents in frog ranvier node treated with local anesthetics Role of slow sodium inactivation

1976 • 200 citations

Actions of saxitoxin on peripheral neuromuscular systems.

1965 • 200 citations

Activation of the action potential Na+ ionophore of cultured neuroblastoma cells by veratridine and batrachotoxin

1975 • 197 citations

Modification of sodium channel gating in frog myelinated nerve fibres by Centruroides sculpturatus scorpion venom.

1975 • 194 citations

On the active structure of local anesthetics.

1961 • 168 citations

Current-Voltage Relations in the Lobster Giant Axon Membrane Under Voltage Clamp Conditions

1962 • 164 citations

An upper limit to the number of sodium channels in nerve membrane?

1967 • 163 citations

The nodes of Ranvier

1952 • 154 citations

Conductance of the sodium channel in myelinated nerve fibres with modified sodium inactivation.

1976 • 133 citations

Evidence That Tetrodotoxin and Saxitoxin Act at a Metal Cation Binding Site in the Sodium Channels of Nerve Membrane

1974 • 131 citations

Properties of the tetrodotoxin binding component in plasma membranes isolated from Electrophorus electricus

1976 • 128 citations

The binding of labelled saxitoxin to the sodium channels in nerve membranes

1973 • 128 citations

Equilibrium and Kinetic Properties of the Interaction between Tetrodotoxin and the Excitable Membrane of the Squid Giant Axon

1970 • 116 citations

Displacement currents in the node of Ranvier

1975 • 111 citations

SITE OF ACTION AND ACTIVE FORM OF LOCAL ANESTHETICS

1971 • 111 citations

The rate of action of tetrodotoxin on myelinated nerve fibres of Xenopus laevis and Rana esculenta

1973 • 106 citations

The permeability of aconitine-modified sodium channels to univalent cations in myelinated nerve

1977 • 102 citations

Sodium channels in nerve apparently have two conductance states

1977 • 101 citations

Specific staining of the axon membrane at nodes of Ranvier with ferric ion and ferrocyanide

1977 • 93 citations

Saltatory Conduction in Nerve

1954 • 88 citations

Partial Characterization of a Tetrodotoxin-Binding Component from Nerve Membrane

1972 • 86 citations

Molecular Size of the Tetrodotoxin Binding Site estimated by Irradiation Inactivation

1973 • 85 citations

Ultrastructure of the Node of Ranvier

1963 • 82 citations

Ultrastructure of the node-paranode region of mature feline ventral lumbar spinal-root fibres.

1968 • 68 citations

The passive electrical properties of the membrane of a molluscan neurone

1972 • 66 citations

The interaction at equilibrium between tetrodotoxin and mammalian non‐myelinated nerve fibres

1972 • 64 citations

Binding to saxitoxin to electrically excitable neuroblastoma cells.

1978 • 62 citations

One-to-one binding of a purified scorpion toxin to Na channels

1977 • 54 citations

Mechanism of action of local anaesthetic agents and biotoxins.

1975 • 45 citations

Mode of action of trichloroethylene on squid axon membranes.

1976 • 42 citations

The mode of action of batrachotoxin.

1972 • 34 citations

Pressure antagonism to nerve conduction block by anesthetic agents.

1977 • 32 citations

The effect of haloperidol on the ionic currents in the voltage-clamped node of Ranvier.

1978 • 17 citations

The Relation of Hydrogen Ion Concentration to the Action of the Local Anæsthetics

1927 • 13 citations