Disruption of Gap Junctional Communication by the Platelet-derived Growth Factor Is Mediated via Multiple Signaling Pathways

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase

1995 • 1,973 citations

The Gap Junction Communication Channel

1996 • 1,896 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Receptor Protein-Tyrosine Kinases and Their Signal Transduction Pathways

1994 • 1,309 citations

Connections with Connexins: the Molecular Basis of Direct Intercellular Signaling

1996 • 1,301 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines.

1990 • 697 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

Activation of phospholipase Cgamma by PI 3-kinase-induced PH domain-mediated membrane targeting

1998 • 561 citations

Platelet-derived growth factor receptor signals.

1994 • 561 citations

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

1989 • 524 citations

The gap junction protein connexin43 interacts with the second PDZ domain of the zona occludens-1 protein

1998 • 521 citations

Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer chemopreventive action

1991 • 518 citations

Direct Association of the Gap Junction Protein Connexin-43 with ZO-1 in Cardiac Myocytes

1998 • 492 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

COMMENTARY: Role of connexin genes in growth control

1996 • 456 citations

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

1994 • 389 citations

Phosphorylation of Connexin43 Gap Junction Protein in Uninfected and Rous Sarcoma Virus-Transformed Mammalian Fibroblasts

1990 • 352 citations

Regulation of Connexin-43 Gap Junctional Intercellular Communication by Mitogen-activated Protein Kinase

1998 • 330 citations

Activation of Both MAP Kinase and Phosphatidylinositide 3-Kinase by Ras Is Required for Hepatocyte Growth Factor/Scatter Factor–induced Adherens Junction Disassembly

1998 • 330 citations

Characterization of the Mitogen-activated Protein Kinase Phosphorylation Sites on the Connexin-43 Gap Junction Protein

1996 • 282 citations

UV activates growth factor receptors via reactive oxygen intermediates.

1996 • 281 citations

Tyrosine phosphorylation of the gap junction protein connexin43 is required for the pp60v-src-induced inhibition of communication.

1990 • 276 citations

EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase.

1996 • 270 citations

Intramolecular interactions mediate pH regulation of connexin43 channels

1996 • 263 citations

The cell-cell channel in the control of growth

1992 • 254 citations

Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma.

1992 • 231 citations

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit.

1992 • 228 citations

Inactivation of Glycogen Synthase Kinase-3 by Epidermal Growth Factor Is Mediated by Mitogen-activated Protein Kinase/p90 Ribosomal Protein S6 Kinase Signaling Pathway in NIH/3T3 Cells

1995 • 216 citations

Epidermal growth factor disrupts gap-junctional communication and induces phosphorylation of connexin43 on serine.

1992 • 192 citations

Tyrosine Phosphorylation of Connexin 43 by v-Src Is Mediated by SH2 and SH3 Domain Interactions

1997 • 187 citations

Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21ras Activation

1995 • 184 citations

Receptor tyrosine kinases and their targets

1994 • 177 citations

Epidermal growth factor stimulates the disruption of gap junctional communication and connexin43 phosphorylation independent of 12-0-tetradecanoylphorbol 13-acetate-sensitive protein kinase C: the possible involvement of mitogen-activated protein kinase.

1993 • 174 citations

Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase.

1996 • 168 citations

Changes in gap‐junction permeability, phosphorylation, and number mediated by phorbol ester and non‐phorbol‐ester tumor promoters in rat liver epithelial cells

1994 • 166 citations

PH regulation of connexin43: molecular analysis of the gating particle

1996 • 164 citations

Tyrosine Phosphorylation Sites at Amino Acids 239 and 240 of Shc Are Involved in Epidermal Growth Factor-Induced Mitogenic Signaling That Is Distinct from Ras/Mitogen-Activated Protein Kinase Activation

1997 • 156 citations

Enhancement of gap junctional communication by retinoids correlates with their ability to inhibit neoplastic transformation

1989 • 154 citations

Dynamin binds to SH3 domains of phospholipase C gamma and GRB-2.

1994 • 151 citations

Requirement of phospholipase C gamma, the tyrosine phosphatase Syp and the adaptor proteins Shc and Nck for PDGF-induced DNA synthesis: evidence for the existence of Ras-dependent and Ras-independent pathways.

1996 • 136 citations

Gap junctions in development—a perspective

1992 • 126 citations

Regulation of connexin43 function by activated tyrosine protein kinases

1996 • 122 citations

Inhibition of Serum- and Ras-Stimulated DNA Synthesis by Antibodies to Phospholipase C

1990 • 122 citations

Phorbol ester induces phosphorylation and down-regulation of connexin 43 in WB cells

1991 • 122 citations

Regulation of Mitogen-activated Protein Kinase Phosphatase-1 Expression by Extracellular Signal-related Kinase-dependent and Ca2+-dependent Signal Pathways in Rat-1 Cells

1997 • 121 citations

Growth factors modulate junctional cell-to-cell communication

1988 • 119 citations

Mitogen-Activated Protein Kinase Activation Is Insufficient for Growth Factor Receptor-Mediated PC12 Cell Differentiation

1995 • 107 citations

Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types.

1993 • 100 citations

Functions of the major tyrosine phosphorylation site of the PDGF receptor beta subunit.

1991 • 96 citations

The Phosphotyrosine Phosphatase PTP1D, but not PTP1C, Is an Essential Mediator of Fibroblast Proliferation Induced by Tyrosine Kinase and G Protein-coupled Receptors

1995 • 93 citations

Platelet-derived growth factor-induced disruption of gap junctional communication and phosphorylation of connexin43 involves protein kinase C and mitogen-activated protein kinase

1998 • 80 citations

REGULATION OF PROLIFERATION OF NORMAL AND NEOPLASTIC RAT LIVER CELLS BY CALCIUM AND CYCLIC AMP

1980 • 78 citations

Rapid disruption of gap junctional communication and phosphorylation of connexin43 by platelet-derived growth factor in T51B rat liver epithelial cells expressing platelet-derived growth factor receptor

1998 • 77 citations

Blocking gap junctional intercellular communication in myoblasts inhibits myogenin and MRF4 expression

1997 • 73 citations

p130gag-fps disrupts gap junctional communication and induces phosphorylation of connexin43 in a manner similar to that of pp60v-src.

1994 • 70 citations

Gap junction-mediated cell-to-cell communication in endocrine glands—molecular and functional aspects: a review

1996 • 67 citations

Platelet-derived growth factor activation of mitogen-activated protein kinase depends on the sequential activation of phosphatidylcholine-specific phospholipase C, protein kinase C-ζ and Raf-1

1997 • 66 citations

Activation of Na+/H+ exchange by platelet-derived growth factor involves phosphatidylinositol 3'-kinase and phospholipase C gamma.

1994 • 62 citations

Platelet-derived Growth Factor-dependent Cellular Transformation Requires Either Phospholipase Cγ or Phosphatidylinositol 3 Kinase

1997 • 57 citations

The GTPase-Activating Protein of Ras Suppresses Platelet-Derived Growth Factor β Receptor Signaling by Silencing Phospholipase C-γ1

1995 • 52 citations

Dissociation of PDGF receptor tyrosine kinase activity from PDGF‐mediated inhibition of gap junctional communication

1994 • 50 citations

A 17mer Peptide Interferes With Acidification-Induced Uncoupling of Connexin43

1998 • 48 citations

U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells

1994 • 44 citations

Effects of peroxisome proliferators and 12-O-tetradecanoyl phorbol-13-acetate on intercellular communication and connexin43 in two hamster fibroblast systems

1997 • 40 citations

Down-Regulation of Gap Junctional Intercellular Communication Between Osteoblastic MC3T3-E1 Cells by Basic Fibroblast Growth Factor and a Phorbol Ester (12-O-Tetradecanoylphorbol-13-Acetate)

1997 • 37 citations

The Platelet-derived Growth Factor β Receptor Triggers Multiple Cytoplasmic Signaling Cascades That Arrive at the Nucleus as Distinguishable Inputs

1997 • 34 citations

Treatment of vascular smooth muscle cells with antisense phosphorothioate oligodeoxynucleotides directed against p42 and p44 mitogen-activated protein kinases abolishes DNA synthesis in response to platelet-derived growth factor

1996 • 32 citations

The use of initiated cells as a test system for the detection of inhibitors of gap junctional intercellular communication

1996 • 26 citations

Analysis of Mutant Platelet-Derived Growth Factor Receptors Expressed in PC12 Cells Identifies Signals Governing Sodium Channel Induction during Neuronal Differentiation

1997 • 24 citations

Relation between colony formation in calciumdashdeficient medium, colony formation in soft agar, and tumor formation by T51B rat liver cells

1984 • 21 citations

Role of the Raf/Mitogen-activated Protein Kinase Pathway in p21 Desensitization

1996 • 18 citations

Platelet-derived growth factor-induced p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or phosphatidylinositol-3-kinase.

1994 • 16 citations

Tyr1009 and Tyr1021 in the platelet-derived growth factor beta-receptor mediate agonist triggered calcium signalling.

1998 • 6 citations