Cancer nanotechnology: opportunities and challenges

Helical microtubules of graphitic carbon

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The Hallmarks of Cancer

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Semiconductor Clusters, Nanocrystals, and Quantum Dots

1996 • 11,065 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

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A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

1986 • 6,585 citations

Nanotube Molecular Wires as Chemical Sensors

2000 • 5,925 citations

Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species

2001 • 5,712 citations

Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance

2003 • 3,814 citations

A New Class of Polymers: Starburst-Dendritic Macromolecules

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Probing the Cytotoxicity of Semiconductor Quantum Dots

2003 • 3,267 citations

The dawning era of polymer therapeutics

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Light-Directed, Spatially Addressable Parallel Chemical Synthesis

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Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots

2002 • 2,464 citations

Drug Delivery and Targeting

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Luminescent quantum dots for multiplexed biological detection and imaging

2002 • 2,035 citations

Long-term multiple color imaging of live cells using quantum dot bioconjugates

2002 • 1,984 citations

Noninvasive Detection of Clinically Occult Lymph-Node Metastases in Prostate Cancer

2003 • 1,965 citations

Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles

2004 • 1,762 citations

Translating Biomolecular Recognition into Nanomechanics

2000 • 1,636 citations

Ligand-targeted therapeutics in anticancer therapy

2002 • 1,592 citations

Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors

2003 • 1,422 citations

Nanocrystal targeting in vivo

2002 • 1,421 citations

Small-scale systems for in vivo drug delivery

2003 • 1,279 citations

Protein Nanoarrays Generated By Dip-Pen Nanolithography

2002 • 1,144 citations

Bioassay of prostate-specific antigen (PSA) using microcantilevers

2001 • 994 citations

Preparation and Properties of Polymer-Wrapped Single-Walled Carbon Nanotubes

2001 • 981 citations

Separation of Long DNA Molecules in a Microfabricated Entropic Trap Array

2000 • 906 citations

Ceramic-Based Nanoparticles Entrapping Water-Insoluble Photosensitizing Anticancer Drugs: A Novel Drug−Carrier System for Photodynamic Therapy

2003 • 902 citations

Encyclopedia Of Controlled Drug Delivery

1999 • 868 citations

Block copolymer micelles as vehicles for drug delivery

1993 • 866 citations

Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging

1998 • 851 citations

The 'right' size in nanobiotechnology

2003 • 815 citations

Multifunctional Gold Nanoparticle−Peptide Complexes for Nuclear Targeting

2003 • 782 citations

Bio-Bar-Code-Based DNA Detection with PCR-like Sensitivity

2004 • 737 citations

Conjugation of Biomolecules with Luminophore-Doped Silica Nanoparticles for Photostable Biomarkers

2001 • 736 citations

Direct Patterning of Modified Oligonucleotides on Metals and Insulators by Dip-Pen Nanolithography

2002 • 715 citations

Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis

2000 • 695 citations

Molecular Imaging of Angiogenesis in Early-Stage Atherosclerosis With α _v β ₃ -Integrin–Targeted Nanoparticles

2003 • 695 citations

Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy

2004 • 693 citations

Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry

2000 • 690 citations

A Whole Blood Immunoassay Using Gold Nanoshells

2003 • 675 citations

Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor.

2002 • 647 citations

Carbon Nanotube Nanoelectrode Array for Ultrasensitive DNA Detection

2003 • 624 citations

In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy

2001 • 603 citations

Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier

2002 • 567 citations

A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation.

2003 • 547 citations

Ultrasensitive DNA Detection Using Highly Fluorescent Bioconjugated Nanoparticles

2003 • 544 citations

Clinical proteomics: Written in blood

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The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs

1975 • 516 citations

Viral-Induced Self-Assembly of Magnetic Nanoparticles Allows the Detection of Viral Particles in Biological Media

2003 • 510 citations

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Biotechnology at low Reynolds numbers

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Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target

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Liposome-based drug delivery in breast cancer treatment

2002 • 443 citations

Chemotherapy of glioblastoma in rats using doxorubicin‐loaded nanoparticles

2004 • 428 citations

Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling.

2002 • 419 citations

The next frontier of molecular medicine: Delivery of therapeutics

1998 • 408 citations

Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging.

2003 • 377 citations

Single molecule measurements of DNA transport through a nanopore

2002 • 375 citations

Integrated nanoliter systems

2003 • 375 citations

Optical Nanosensors for Chemical Analysis inside Single Living Cells. 1. Fabrication, Characterization, and Methods for Intracellular Delivery of PEBBLE Sensors

1999 • 360 citations

Protein Nanostructures Formed via Direct-Write Dip-Pen Nanolithography

2003 • 340 citations

Persistence of Solitary Mammary Carcinoma Cells in a Secondary Site: A Possible Contributor to Dormancy

2002 • 337 citations

Cantilever-Based Optical Deflection Assay for Discrimination of DNA Single-Nucleotide Mismatches

2001 • 332 citations

Optical Nanosensors for Chemical Analysis inside Single Living Cells. 2. Sensors for pH and Calcium and the Intracellular Application of PEBBLE Sensors

1999 • 322 citations

Designing Macromolecules for Therapeutic Applications: Polyester DendrimerPoly(ethylene oxide) “Bow-Tie” Hybrids with Tunable Molecular Weight and Architecture

2002 • 317 citations

Nanochemistry: Synthesis and Characterization of Multifunctional Nanoclinics for Biological Applications

2002 • 317 citations

Comparison of cell uptake, biodistribution and tumor retention of folate-coated and PEG-coated gadolinium nanoparticles in tumor-bearing mice

2004 • 288 citations

Magnetic resonance contrast enhancement of neovasculature with ?v?3-targeted nanoparticles

2000 • 274 citations

Targeted nanoparticles for quantitative imaging of sparse molecular epitopes with MRI

2004 • 274 citations

Bioconjugated Nanoparticles for DNA Protection from Cleavage

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Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery.

1995 • 263 citations

Brain uptake of thiamine-coated nanoparticles

2003 • 251 citations

Microcantilever resonance-based DNA detection with nanoparticle probes

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Chronopharmaceutics: gimmick or clinically relevant approach to drug delivery?

2004 • 230 citations

True

2000 • 222 citations

Optical observation of lipid- and polymer-shelled ultrasound microbubble contrast agents

2004 • 213 citations

Imaging of iron oxide nanoparticles by MR and light microscopy in patients with malignant brain tumours

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Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger.

1998 • 211 citations

Mortality and immortality at the cellular level. A review.

1997 • 204 citations

Poly(ethylene oxide)-modified poly(β-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery

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Microfabricated immunoisolating biocapsules

1998 • 198 citations

Lectin-bearing polymerized liposomes as potential oral vaccine carriers.

1996 • 193 citations

Delivery of molecular and cellular medicine to solid tumors

1998 • 190 citations

Untitled

1999 • 184 citations

Determination of the Bioavailability of Biotin Conjugated onto Shell Cross-Linked (SCK) Nanoparticles

2004 • 179 citations

In SituBlood–Brain Barrier Transport of Nanoparticles

2003 • 175 citations

Direct haplotyping of kilobase-size DNA using carbon nanotube probes

2000 • 171 citations

Novel Nanosensors for Rapid Analysis of Telomerase Activity

2004 • 165 citations

Nanoporous anti-fouling silicon membranes for biosensor applications

2000 • 161 citations

A novel antiangiogenesis therapy using an integrin antagonist or anti–Flk-1 antibody coated 90Y-labeled nanoparticles

2004 • 158 citations

A 2-D Microcantilever Array for Multiplexed Biomolecular Analysis

2004 • 156 citations

Annexin V–CLIO: A Nanoparticle for Detecting Apoptosis by MRI

2002 • 154 citations

Annexin V–CLIO: A Nanoparticle for Detecting Apoptosis by MRI

2002 • 153 citations

Lymphatic Drainage Imaging of Breast Cancer in Mice by Micro-Magnetic Resonance Lymphangiography Using a Nano-Size Paramagnetic Contrast Agent

2004 • 152 citations

Tailoring width of microfabricated nanochannels to solute size can be used to control diffusion kinetics

2004 • 151 citations

Interstitial Stress and Fluid Pressure Within a Growing Tumor

2003 • 146 citations

The Embedding of Meta-tetra(Hydroxyphenyl)-Chlorin into Silica Nanoparticle Platforms for Photodynamic Therapy and Their Singlet Oxygen Production and pH-dependent Optical Properties¶

2003 • 145 citations

Serum Proteomics in Cancer Diagnosis and Management

2004 • 143 citations

Nanostructured Materials Designed for Cell Binding and Transduction

2001 • 130 citations

Dynamics and fragmentation of thick-shelled microbubbles

2002 • 117 citations

Bioadhesive poly(methyl methacrylate) microdevices for controlled drug delivery

2003 • 113 citations

Self-Assembled Coatings on Individual Monodisperse Magnetite Nanoparticles for Efficient Intracellular Uptake

2004 • 105 citations

Untitled

2001 • 103 citations

An Addressable Antibody Nanoarray Produced on a Nanostructured Surface

2004 • 99 citations

Nanoengineered device for drug delivery application

2004 • 98 citations

Two-Dimensional Chemotherapy Simulations Demonstrate Fundamental Transport and Tumor Response Limitations Involving Nanoparticles

2004 • 95 citations

Molecular Imaging Applications in Nanomedicine

2004 • 89 citations

Microfabricated biocapsules provide short-term immunoisolation of insulinoma xenografts.

1999 • 86 citations

Optical nanosensors for chemical analysis inside single living *cells.

1999 • 79 citations

Untitled

2001 • 78 citations

Spectroscopic Approach for On-Line Monitoring of Particle Size during the Processing of Pharmaceutical Nanoparticles

2003 • 70 citations

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2002 • 67 citations

NanoSystems biology

2003 • 67 citations

Enhanced cellular uptake of a triplex-forming oligonucleotide by nanoparticle formation in the presence of polypropylenimine dendrimers

2004 • 63 citations

Untitled

2000 • 61 citations

Silicon membrane nanofilters from sacrificial oxide removal

1999 • 61 citations

Nanotechnology in Early Detection of Cancer

2002 • 60 citations

Nanotechnology and Tumor Imaging: Seizing an Opportunity

2004 • 60 citations

Release of Biologically Functional Interferon-Alpha from a Nanochannel Delivery System

2005 • 56 citations

Adhesion of Microfabricated Particles on Vascular Endothelium: A Parametric Analysis

2004 • 56 citations

Bioassays Based on Molecular Nanomechanics

2002 • 54 citations

Biochemical and Immunological Properties of Cytokines Conjugated to Dendritic Polymers

2004 • 53 citations

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2003 • 50 citations

Detection of functional groups and antibodies on microfabricated surfaces by confocal microscopy

1998 • 50 citations

Synthesis and Characterization of Silica-Embedded Iron Oxide Nanoparticles for Magnetic Resonance Imaging

2004 • 43 citations

Opportunities for Nanotechnology-Based Innovation in Tissue Proteomics

2004 • 32 citations

Vector Targeting for Therapeutic Gene Delivery

2002 • 31 citations

Untitled

2001 • 27 citations

Microelectronic DNA Assay for the Detection of BRCA1 Gene Mutations

2004 • 13 citations

Determination of Eigenstresses from Curvature Data

1992 • 2 citations