The soluble interleukin 6 receptor: mechanisms of production and implications in disease

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1998 • 2,072 citations

The biology of interleukin-6

1989 • 1,964 citations

Impaired immune and acute-phase responses in interleukin-6-deficient mice

1994 • 1,776 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-α

1997 • 1,608 citations

An Essential Role for Ectodomain Shedding in Mammalian Development

1998 • 1,607 citations

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.

1998 • 1,463 citations

The biology of interleukin-6

1989 • 1,459 citations

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

1992 • 1,437 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Interleukin-6 family of cytokines and gp130

1995 • 1,314 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Acute Phase Proteins with Special Reference to C-Reactive Protein and Related Proteins (Pentaxins) and Serum Amyloid A Protein

1983 • 1,283 citations

Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo

2000 • 1,255 citations

Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment

1997 • 1,091 citations

Cloning and Expression of the Human Interleukin-6 (BSF-2/IFNβ 2) Receptor

1988 • 1,063 citations

Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors

1995 • 992 citations

Correlations and interactions in the production of interleukin-6 (IL- 6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

1990 • 991 citations

Interleukin‐6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides

1988 • 859 citations

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.

1993 • 827 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

Increased plasma levels of interleukin-6 in sepsis [see comments]

1989 • 813 citations

Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55

1994 • 799 citations

Soluble receptors for cytokines and growth factors: generation and biological function

1994 • 766 citations

IL-6-Induced Homodimerization of gp130 and Associated Activation of a Tyrosine Kinase

1993 • 730 citations

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.

1996 • 635 citations

LIFRβ and gp130 as Heterodimerizing Signal Transducers of the Tripartite CNTF Receptor

1993 • 632 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

Interleukin 6 Is Required for the Development of Collagen-induced Arthritis

1998 • 605 citations

Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6.

1993 • 587 citations

Disruption of the CNTF gene results in motor neuron degeneration

1993 • 566 citations

Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy.

1995 • 548 citations

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

1996 • 538 citations

Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and post-transcriptional mechanisms.

1990 • 529 citations

Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis.

1989 • 514 citations

Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.

1995 • 504 citations

The soluble interleukin‐6 receptor is generated by shedding

1993 • 502 citations

Soluble cytokine receptors are present in normal human urine.

1989 • 441 citations

Cardiotrophin-1

1995 • 432 citations

IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade.

1997 • 416 citations

Involvement of IL-6 in mesangial proliferative glomerulonephritis.

1989 • 415 citations

IL-6 Is Required for the Development of Th1 Cell-Mediated Murine Colitis

2000 • 412 citations

Interleukin 6 plays a key role in the development of antigen-induced arthritis

1998 • 404 citations

Diverse Cell Surface Protein Ectodomains Are Shed by a System Sensitive to Metalloprotease Inhibitors

1996 • 404 citations

Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130

1993 • 402 citations

Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors.

1995 • 396 citations

Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor

1992 • 388 citations

The Major Receptor for C-Reactive Protein on Leukocytes Is Fcγ Receptor II

1999 • 382 citations

Interleukin-2 and interleukin-6 in schizophrenia and mania: Effects of neuroleptics and mood stabilizers

1995 • 382 citations

Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events

1999 • 369 citations

Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation

1993 • 367 citations

Correlation of Serum Interleukin‐6 Levels with Joint Involvement and Thrombocytosis in Systemic Juvenile Rheumatoid Arthritis

1991 • 364 citations

Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130

1993 • 360 citations

Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors

1994 • 359 citations

Released Form of CNTF Receptor α Component as a Soluble Mediator of CNTF Responses

1993 • 350 citations

Converting enzyme-independent release of tumor necrosis factor α and IL-1β from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3

1999 • 346 citations

Human soluble IL-6 receptor: its detection and enhanced release by HIV infection.

1992 • 342 citations

Sympathetic neurons can produce and respond to interleukin 6

1998 • 336 citations

Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma.

1996 • 321 citations

Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130

1996 • 310 citations

Neutrophil rolling altered by inhibition of L-selectin shedding in vitro

1996 • 285 citations

Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo.

1992 • 284 citations

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.

1996 • 284 citations

Treatment of severe rheumatoid arthritis by anti-interleukin 6 monoclonal antibody.

1993 • 278 citations

The soluble human IL-6 receptor. Mutational characterization of the proteolytic cleavage site.

1994 • 275 citations

Interleukin-6 prevents dexamethasone-induced myeloma cell death

1994 • 275 citations

Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis

1998 • 272 citations

A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor.

1995 • 254 citations

Interleukin-6 and Soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis

1998 • 247 citations

Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation.

1991 • 244 citations

Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family

1999 • 238 citations

A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes.

1995 • 234 citations

Interleukin-6 (IL-6) Production by Astrocytes: Autocrine Regulation by IL-6 and the Soluble IL-6 Receptor

1999 • 229 citations

Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model

1993 • 208 citations

Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6.

1991 • 207 citations

Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.

1992 • 206 citations

Increased and highly stable levels of functional soluble interleukin‐6 receptor in sera of patients with monoclonal gammopathy

1993 • 206 citations

Identification and Characterization of a Pro-tumor Necrosis Factor-α-processing Enzyme from the ADAM Family of Zinc Metalloproteases

1997 • 204 citations

INTERLEUKIN-6 (IL-6) INDUCES THE PROLIFERATION OF SYNOVIAL FIBROBLASTIC CELLS IN THE PRESENCE OF SOLUBLE IL-6 RECEPTOR

1995 • 202 citations

Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha.

1997 • 201 citations

The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures.

1996 • 200 citations

Soluble interleukin‐6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism

1994 • 197 citations

C-reactive Protein: A Physiological Activator of Interleukin 6 Receptor Shedding

1999 • 194 citations

Interleukin-6 and Soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis

1998 • 192 citations

Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6.

1995 • 176 citations

Cytokine signaling during myocardial infarction: sequential appearance of IL-1 beta and IL-6

1995 • 174 citations

Novel Path to Activation of Vascular Smooth Muscle Cells: Up-Regulation of gp130 Creates an Autocrine Activation Loop by IL-6 and Its Soluble Receptor

1999 • 171 citations

Cytokine regulation of CC and CXC chemokine expression by human astrocytes

1999 • 171 citations

Extramedullary Expansion of Hematopoietic Progenitor Cells in Interleukin (IL)-6–sIL-6R Double Transgenic Mice

1997 • 171 citations

gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cells.

1995 • 166 citations

Proteolytic Cleavage of ICAM-1 by Human Neutrophil Elastase

1998 • 164 citations

Soluble IL-6 Receptor Potentiates the Antagonistic Activity of Soluble gp130 on IL-6 Responses

1998 • 163 citations

Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cells.

1994 • 162 citations

Association and activation of Btk and Tec tyrosine kinases by gp130, a signal transducer of the interleukin-6 family of cytokines

1995 • 160 citations

Soluble interleukin‐6 (IL‐6) receptor augments central effects of IL‐6 in vivo

1995 • 160 citations

Prevention of In vitro neutrophil adhesion to endothelial cells through shedding of L-selectin by C-reactive protein and peptides derived from C-reactive protein.

1997 • 160 citations

Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell lines

1988 • 156 citations

Serum levels of interleukin‐6 type cytokines and soluble interleukin‐6 receptor in patients with rheumatoid arthritis

1998 • 152 citations

Activation of Fes Tyrosine Kinase by gp130, an Interleukin-6 Family Cytokine Signal Transducer, and Their Association

1995 • 147 citations

Interleukin-6 is a prognostic factor in multiple myeloma [letter] [see comments]

1991 • 145 citations

Human atherosclerotic abdominal aortic aneurysms produce interleukin (IL)-6 and interferon-gamma but not IL-2 and IL-4: The possible role for IL-6 and interferon-gamma in vascular inflammation

1994 • 144 citations

Increased serum concentrations of interleukin-6 (IL-6) and soluble IL-6 receptor in patients with Graves' disease.

1996 • 137 citations

INTERLEUKIN 6 KNOCK-OUT MICE ARE RESISTANT TO ANTIGEN-INDUCED EXPERIMENTAL ARTHRITIS

1999 • 136 citations

Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver

1998 • 133 citations

Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluid.

1997 • 132 citations

Analysis of interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34+ cells.

1996 • 125 citations

Proteolysis of monocyte CD14 by human leukocyte elastase inhibits lipopolysaccharide-mediated cell activation

1999 • 122 citations

Leukemia inhibitory factor, a cytokine at the interface between neurobiology and immunology.

1994 • 122 citations

Protein kinase C activity is rate limiting for shedding of the interleukin-6 receptor

1992 • 122 citations

Interleukin-6 is a prognostic factor in multiple myeloma [letter] [see comments]

1991 • 120 citations

Differential shedding of the two subunits of the interleukin‐6 receptor

1993 • 120 citations

Interleukin (IL)-6 and Its Soluble Receptor Induce TIMP-1 Expression in Synoviocytes and Chondrocytes, and Block IL-1-induced Collagenolytic Activity

1998 • 112 citations

Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts

1999 • 111 citations

Hydroxamate-based metalloprotease inhibitor blocks shedding of L-selectin adhesion molecule from leukocytes: functional consequences for neutrophil aggregation.

1996 • 106 citations

Role of IL-6 and the Soluble IL-6 Receptor in Inhibition of VCAM-1 Gene Expression

1998 • 104 citations

Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide.

1996 • 104 citations

A POSSIBLE ROLE FOR SOLUBLE IL-6 RECEPTOR IN THE PATHOGENESIS OF SYSTEMIC ONSET JUVENILE CHRONIC ARTHRITIS

1998 • 98 citations

Novel pathogenic mechanism of microbial metalloproteinases: liberation of membrane-anchored molecules in biologically active form exemplified by studies with the human interleukin-6 receptor

1996 • 94 citations

Human myeloma cells shed the interleukin‐6 receptor: inhibition by tissue inhibitor of metalloproteinase‐3 and a hydroxamate‐based metalloproteinase inhibitor

1998 • 94 citations

Enhanced production of interleukin-6 (IL-6), oncostatin M and soluble IL-6 receptor by cultured peripheral blood mononuclear cells from patients with systemic sclerosis

1999 • 94 citations

Apical Enrichment of Human EGF Precursor in Madin-Darby Canine Kidney Cells Involves Preferential Basolateral Ectodomain Cleavage Sensitive to a Metalloprotease Inhibitor

1997 • 90 citations

Hepatocellular Hyperplasia, Plasmacytoma Formation, and Extramedullary Hematopoiesis in Interleukin (IL)-6/Soluble IL-6 Receptor Double-Transgenic Mice

1998 • 88 citations

Involvement of Janus kinases, p52shc, Raf-1, and MEK-1 in the IL-6-induced mitogen-activated protein kinase cascade of a growth-responsive B cell line.

1994 • 87 citations

Selective Proteolytic Cleavage of IL-2 Receptor and IL-6 Receptor Ligand Binding Chains by Neutrophil-Derived Serine Proteases at Foci of Inflammation

1999 • 87 citations

CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosis1Part of this work was presented in abstract form at the Twenty-Seventh Annual Meeting of the Society for Neuroscience, October 25–30, 1997, New Orleans, LA, USA.1

1999 • 84 citations

Soluble interleukin‐6 receptor as a prognostic factor in multiple myeloma

1996 • 84 citations

Relationship of serum levels of interleukin-6, soluble interleukin-6 receptor and tumour necrosis factor receptors to the acute-phase protein response in advanced pancreatic cancer

1999 • 83 citations

Soluble interleukin‐6 receptor (sIL‐6R), a new prognostic factor in multiple myeloma

1996 • 82 citations

Interleukin-6 and Its Soluble Receptor Cause a Marked Induction of Collagenase 3 Expression in Rat Osteoblast Cultures

1997 • 80 citations

Human C-reactive protein inhibits neutrophil chemotaxis in vitro: possible implications for the adult respiratory distress syndrome.

1990 • 79 citations

Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients

1997 • 77 citations

Cloning and expression of an alternatively spliced mRNA encoding a soluble form of the human interleukin‐6 signal transducer gp130¹

1997 • 76 citations

Circulating Interleukin-6 Receptor in Patients with Sepsis Syndrome

1995 • 73 citations

Interleukin-6 and its soluble receptor in serum and cerebrospinal fluid after cerebral trauma

1999 • 71 citations

Shedding of the soluble IL-6 receptor is triggered by Ca2+ mobilization, while basal release is predominantly the product of differential mRNA splicing in THP-1 cells

1998 • 71 citations

Purification and Characterization of the Soluble Interleukin‐6 Receptor from Human Plasma and Identification of An Isoform Generated through Alternative Splicing

1996 • 69 citations

Is IL-6 both a cytokine and a neurotrophic factor?

1996 • 64 citations

A gp130 Interleukin-6 Transducer-Dependent SCID Model of Human Multiple Myeloma

1998 • 61 citations

Circulating Levels of Soluble Interleukin-6 Receptor in Patients with Bronchial Asthma

1997 • 60 citations

Converting enzyme-independent release of tumor necrosis factor a and IL-1b from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3 (neutrophil elastaseycytokine processingyproteinase inhibitors)

1999 • 59 citations

Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression: no alteration of soluble gp130

1999 • 59 citations

Major role of the soluble interleukin‐6/interleukin‐6 receptor complex for the proliferation of interleukin‐6‐dependent human myeloma cell lines

1997 • 57 citations

Functional Expression of Soluble Human Interleukin-11 (IL-11) Receptor α and Stoichiometry of in Vitro IL-11 Receptor Complexes with gp130

1996 • 57 citations

Increased serum concentrations of interleukin-6 (IL-6) and soluble IL-6 receptor in patients with Graves' disease

1996 • 56 citations

Effects of IL-6 and its soluble receptor on proteoglycan synthesis and NO release by human articular chondrocytes: comparison with IL-1. Modulation by dexamethasone

1999 • 54 citations

The soluble form of the IL-6 receptor (sIL-6Rα) is a potent growth factor for AIDS-associated Kaposi's sarcoma (KS) cells; the soluble form of gp130 is antagonistic for sIL-6Rα-induced AIDS-KS cell growth

1996 • 52 citations

A fusion protein of interleukin‐11 and soluble interleukin‐11 receptor acts as a superagonist on cells expressing gp130

1999 • 52 citations

Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer's disease

1998 • 51 citations

Correlation of synovial fluid interleukin 6 (IL-6) activities with IgG concentrations in patients with inflammatory joint disease and osteoarthritis.

1989 • 51 citations

Soluble IL-6 receptor leads to a paracrine modulation of the IL-6-induced hepatic acute phase response in double transgenic mice.

1997 • 50 citations

Association of p72 tyrosine kinase with Stat factors and its activation by interleukin-3, interleukin-6, and granulocyte colony-stimulating factor

1994 • 48 citations

Increased concentrations of interleukin-6 and interleukin-1 receptor antagonist and decreased concentrations of beta-2-glycoprotein I in Gambian children with cerebral malaria

1994 • 47 citations

Characterization of soluble gp130 released by melanoma cell lines: A polyvalent antagonist of cytokines from the interleukin 6 family.

1997 • 42 citations

The Membrane Proximal Cytokine Receptor Domain of the Human Interleukin-6 Receptor Is Sufficient for Ligand Binding but Not for gp130 Association

1998 • 40 citations

Effects of C-reactive protein on human neutrophil granulocytes challenged with N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor

1989 • 40 citations

Clinical significance of elevated soluble interleukin‐6 receptor levels in the sera of patients with plasma cell dyscrasias

1995 • 39 citations

Soluble Interleukin-6 (IL-6) Receptor With IL-6 Stimulates Megakaryopoiesis From Human CD34+ Cells Through Glycoprotein (gp)130 Signaling

1999 • 39 citations

High‐level production of alternatively spliced soluble interleukin‐6 receptor in serum of patients with adult T‐cell leukaemia/HTLV‐I‐associated myelopathy

1998 • 36 citations

Evaluation of soluble IL-6 receptor concentration in serum and epithelial lining fluid from patients with interstitial lung diseases

1995 • 34 citations

A SOLUBLE INTERLEUKIN 6 RECEPTOR ISOLATED FROM CONDITIONED MEDIUM OF HUMAN BREAST CANCER CELLS IS ENCODED BY A DIFFERENTIALLY SPLICED mRNA

1996 • 33 citations

Yeast expression of the cytokine receptor domain of the soluble interleukin-6 receptor

1996 • 32 citations

Relationship of serum levels of interleukin-6, soluble interleukin-6 receptor and tumour necrosis factor receptors to the acute-phase protein response in advanced pancreatic cancer

1999 • 32 citations

Myeloma cells release soluble interleukin-6Ralpha in relation to disease progression by two distinct mechanisms: alternative splicing and proteolytic cleavage.

1999 • 31 citations

Isolation of liver and muscle polyribosomes in high yield after cell disruption by nitrogen cavitation

1968 • 30 citations

Establishment and characterization of a human stroma-dependent myeloma cell line (MM5.1) and its stroma-independent variant (MM5.2)

1997 • 30 citations

Soluble human interleukin‐6‐receptor modulates interleukin‐6‐dependent N‐glycosylation of α₁‐protease inhibitor secreted by HepG2 cells

1992 • 29 citations

Cytokines oncostatin M and interleukin 1 regulate the expression of the IL-6 receptor (gp80, gp130)

1995 • 27 citations

Cardiotrophin‐1 Induces the Same Neuropeptides in Sympathetic Neurons as Do Neuropoietic Cytokines

1997 • 27 citations

Interleukin-6 and soluble interleukin-6 receptor in peritoneal fluid and serum of patients with endometriosis.

1996 • 27 citations

Interleukin 6 and its soluble receptor are elevated in aqueous humor of patients with uveitis

1999 • 27 citations

Induction of myelin gene expression in Schwann cell cultures by an interleukin‐6 receptor‐interleukin‐6 chimera

1999 • 26 citations

LIF and OM Directly Interact with a Soluble Form of gp130, the IL-6 Receptor Signal Transducing Subunit

1994 • 25 citations

Interleukin-6 and transforming growth factor-β regulate the expression of monocyte chemoattractant protein-1 and colony-stimulating factors in human thyroid follicular cells

1999 • 24 citations

Serum soluble IL-6 receptor concentrations correlate with stages of multiple myeloma defined by serum beta 2-microglobulin and C-reactive protein.

1997 • 23 citations

Oncostatin M stimulates the expression and release of the IL-6 receptor in human hepatoma HepG2 cells.

1997 • 21 citations

Soluble Interleukin-6 Receptor, Interleukin-10 and Granulocyte Colony-Stimulating Factor in Acute Pyelonephritis: Relationship to Markers of Bacterial Virulence and Renal Function

1998 • 20 citations

Interleukin-6 and its soluble receptor during acute meningococcal infections

1996 • 20 citations

Effect of Soluble Interleukin-6 Receptor on Interleukin-6 Synthesis in Human Skin Fibroblasts

1996 • 18 citations

CHANGES IN sIL-6R AND sTNF-Rs RELEASE BY PMNs AND THE SERUM LEVELS IN BREAST CANCER PATIENTS AT DIFFERENT STAGES OF TREATMENT

1998 • 14 citations

Elevated Serum Levels of the Soluble Form of gp130, the IL‐6 Signal Transducer, in HTLV‐1 Infection and No Involvement of Alternative Splicing for Its Generation

1998 • 8 citations

Release of the Soluble Interleukin-6 Receptor from Human T-Cells

1998 • 5 citations