Leukemia inhibitory factor, a cytokine at the interface between neurobiology and immunology.

Cytokine signal transduction

1994 • 1,358 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Effect of Neuropeptides on Production of Inflammatory Cytokines by Human Monocytes

1988 • 929 citations

Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy

1990 • 840 citations

Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

1994 • 822 citations

Mast cells as a source of multifunctional cytokines

1990 • 708 citations

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

1992 • 693 citations

Mast cells synthesize, store, and release nerve growth factor.

1994 • 667 citations

The Receptor for Ciliary Neurotrophic Factor

1991 • 604 citations

Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.

1991 • 587 citations

Disruption of the CNTF gene results in motor neuron degeneration

1993 • 566 citations

Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

1992 • 559 citations

Neuropoietic cytokines in the hematopoietic fold

1991 • 474 citations

Control of Embryonic Motoneuron Survival in Vivo by Ciliary Neurotrophic Factor

1991 • 448 citations

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6.

1991 • 372 citations

Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation

1993 • 367 citations

Nervous tissue as an immune compartment: the dialect of the immune response in the CNS

1994 • 366 citations

Synthesis and localization of ciliary neurotrophic factor in the sciatic nerve of the adult rat after lesion and during regeneration.

1992 • 365 citations

Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo

1992 • 309 citations

Neuronal differentiation factors/cytokines and synaptic plasticity

1993 • 289 citations

Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor.

1989 • 280 citations

The Influence of Non-Neuronal Cells on Catecholamine and Acetylcholine Synthesis and Accumulation in Cultures of Dissociated Sympathetic Neurons

1974 • 277 citations

Trigeminal sensory fiber stimulation induces morphological changes reflecting secretion in rat dura mater mast cells

1991 • 273 citations

Mast cells: The immune gate to the brain

1990 • 268 citations

Retrograde axonal transport of LIF is increased by peripheral nerve injury: Correlation with increased LIF expression in distal nerve

1994 • 268 citations

Mediators of Immediate Hypersensitivity Reactions

1987 • 262 citations

Leukemia inhibitory factor mediates an injury response but not a target-directed developmental transmitter switch in sympathetic neurons

1993 • 244 citations

Major changes in the expression of the mRNAs for cholinergic differentiation factor/leukemia inhibitory factor and its receptor after injury to adult peripheral nerves and ganglia.

1994 • 228 citations

Neuroimmune networks: physiology and diseases

1990 • 228 citations

Interleukin 1 receptors in the brain and endocrine tissues

1993 • 228 citations

Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice

1990 • 226 citations

Purification and partial characterization of a cholinergic neuronal differentiation factor.

1985 • 211 citations

Peptides and neurogenic inflammation

1987 • 209 citations

A null mutation in the human CNTF gene is not causally related to neurological diseases

1994 • 202 citations

Neuroimmunology

1986 • 197 citations

The Role of Mast Cells in Inflammatory Processes: Evidence for Nerve/Mast Cell Interactions

1987 • 196 citations

Neuropoietic cytokines and activin A differentially regulate the phenotype of cultured sympathetic neurons.

1994 • 167 citations

Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factor

1992 • 163 citations

The Neuropeptide Substance P Stimulates Production of Interleukin 1 in Human Blood Monocytes: Activated Cells are Preferentially Influenced by the Neuropeptide

1990 • 152 citations

Cytokine regulation of substance P expression in sympathetic neurons.

1991 • 142 citations

The emerging neuropoietic cytokine family: first CDF/LIF, CNTF and IL-6; next ONC, MGF, GCSF?

1992 • 135 citations

Involvement of leukemia inhibitory factor and nerve growth factor in the development of dorsal root ganglion neurons

1993 • 132 citations

Neurogenic inflammation, vascular permeability, and mast cells.

1988 • 132 citations

Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system.

1993 • 130 citations

Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis.

1992 • 127 citations

Substance P, neurokinin A, and neurokinin B induce generation of IL-1-like activity in P388D1 cells. Possible relevance to arthritic disease.

1988 • 126 citations

Transforming growth factor β has neurotrophic actions on sensory neurons in vitro and is synergistic with nerve growth factor

1992 • 121 citations

Migration of mast cells in the developing rat brain

1990 • 118 citations

Increase in substance P and CGRP, but not somatostatin content of innervating dorsal root ganglia in adjuvant monoarthritis in the rat

1992 • 115 citations

Regulation of vasoactive intestinal peptide expression in sympathetic neurons in culture and after axotomy: The role of cholinergic differentiation factor/leukemia inhibitory factor

1994 • 113 citations

Mediators of human mast cells and human mast cell subsets.

1987 • 112 citations

Cytokines in neuronal cell types

1993 • 108 citations

Leukemia inhibitory factor prevents the death of axotomised sensory neurons in the dorsal root ganglia of the neonatal rat

1994 • 107 citations

Leukemia inhibitory factor levels are elevated in septic shock and various inflammatory body fluids.

1992 • 105 citations

Induction of the gene encoding pro-dynorphin by experimentally induced arthritis enhances staining for dynorphin in the spinal cord of rats

1989 • 103 citations

Interleukin-1 induces substance P in sympathetic ganglia through the induction of leukemia inhibitory factor (LIF)

1993 • 99 citations

Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies.

1994 • 96 citations

Cytokines and neurokines: related ligands and related receptors

1992 • 95 citations

Binding and retrograde transport of leukemia inhibitory factor by the sensory nervous system

1992 • 87 citations

Mast cells with gonadotropin-releasing hormone-like immunoreactivity in the brain of doves.

1994 • 80 citations

Generation of Neuronal Diversity: Analogies and Homologies with Hematopoiesis

1990 • 79 citations

Peptidergic innervation of rat lymphoid tissue and lung: Relation to mast cells and sensitivity to capsaicin and immunization

1990 • 78 citations

Neuropeptides and gastrointestinal immunity

1986 • 76 citations

Neuromedin U octapeptide alters ion transport in porcine jejunum

1988 • 75 citations

Cytokines in neural regeneration

1992 • 74 citations

Leukemia inhibitory factor induces neurotransmitter switching in transgenic mice.

1994 • 72 citations

Increased levels of leukemia inhibitory factor in synovial fluid from patients with rheumatoid arthritis and other inflammatory arthritides

1993 • 72 citations

Multiple cholinergic differentiation factors are present in footpad extracts: comparison with known cholinergic factors

1992 • 66 citations

Recombinant human leukemia inhibitory factor induces acute phase proteins and raises the blood platelet counts in nonhuman primates

1993 • 65 citations

Induction of somatostatin immunoreactivity in cultured ciliary ganglion neurons by activin in choroid cell-conditioned medium

1993 • 65 citations

A Novel Approach to Screen for Cytokine Effects on Neuronal Gene Expression

1993 • 60 citations

Substance P, Cytokines, and Arthritis

1990 • 59 citations

Neuroimmune Networks: Physiology and Disease

1991 • 54 citations

Peripheral nerve injury down‐regulates CNTF expression in adult rat sciatic nerves

1992 • 54 citations

Cholinergic neuronal differentiation factors: evidence for the presence of both CNTF-like and non-CNTF-like factors in developing rat footpad

1992 • 50 citations

Decreased synthesis of ciliary neurotrophic factor in degenerating peripheral nerves

1992 • 49 citations

Neurotransmitter signaling of cells of the immune system: Important progress, major gaps

1991 • 47 citations

Arthritis and the nervous system

1989 • 42 citations

Neural—immune interactions in sympathetic ganglia

1993 • 41 citations

Leukemia inhibitory factor production by rat mast cells

1993 • 40 citations

Substance P, the Immune System and Inflammation

1989 • 38 citations

Non-neuronal cells inhibit catecholaminergic differentiation of primary sensory neurons: role of leukemia inhibitory factor

1993 • 31 citations

HILDA/LIF URINARY EXCRETION DURING ACUTE KIDNEY REJECTION

1992 • 28 citations

Substance P: A Modulator of Neuroendocrine-Immune Function

1989 • 27 citations