C-reactive Protein: A Physiological Activator of Interleukin 6 Receptor Shedding

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1998 • 2,072 citations

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses.

1998 • 1,463 citations

Acute Phase Proteins with Special Reference to C-Reactive Protein and Related Proteins (Pentaxins) and Serum Amyloid A Protein

1983 • 1,283 citations

Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment

1997 • 1,091 citations

Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55

1994 • 799 citations

Soluble receptors for cytokines and growth factors: generation and biological function

1994 • 766 citations

Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing

1994 • 607 citations

Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation

1996 • 538 citations

Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.

1995 • 504 citations

The soluble interleukin‐6 receptor is generated by shedding

1993 • 502 citations

Diverse Cell Surface Protein Ectodomains Are Shed by a System Sensitive to Metalloprotease Inhibitors

1996 • 404 citations

Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors.

1995 • 396 citations

Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor

1992 • 388 citations

Human soluble IL-6 receptor: its detection and enhanced release by HIV infection.

1992 • 342 citations

A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor.

1995 • 254 citations

INTERLEUKIN-6 (IL-6) INDUCES THE PROLIFERATION OF SYNOVIAL FIBROBLASTIC CELLS IN THE PRESENCE OF SOLUBLE IL-6 RECEPTOR

1995 • 202 citations

Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha.

1997 • 201 citations

Soluble interleukin‐6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism

1994 • 197 citations

Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6.

1995 • 176 citations

C-reactive protein binds to Fc gamma RI in transfected COS cells.

1995 • 163 citations

Prevention of In vitro neutrophil adhesion to endothelial cells through shedding of L-selectin by C-reactive protein and peptides derived from C-reactive protein.

1997 • 160 citations

Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell lines

1988 • 156 citations

Concentrations and origins of soluble interleukin 6 receptor-alpha in serum and synovial fluid.

1997 • 132 citations

Testosterone and IL-6 Requirements for Human C-Reactive Protein Gene Expression in Transgenic Mice

1998 • 122 citations

Hydroxamate-based metalloprotease inhibitor blocks shedding of L-selectin adhesion molecule from leukocytes: functional consequences for neutrophil aggregation.

1996 • 106 citations

Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide.

1996 • 104 citations

C-reactive protein

1997 • 100 citations

Soluble interleukin‐6 receptor (sIL‐6R), a new prognostic factor in multiple myeloma

1996 • 82 citations

Rabbits with elevated serum C-reactive protein exhibit diminished neutrophil infiltration and vascular permeability in C5a-induced alveolitis.

1993 • 79 citations

Human C-reactive protein inhibits neutrophil chemotaxis in vitro: possible implications for the adult respiratory distress syndrome.

1990 • 79 citations

Shedding of the soluble IL-6 receptor is triggered by Ca2+ mobilization, while basal release is predominantly the product of differential mRNA splicing in THP-1 cells

1998 • 71 citations

Transgenic mice expressing rabbit C-reactive protein exhibit diminished chemotactic factor-induced alveolitis.

1996 • 67 citations

Tumor Necrosis Factor-α and Interleukin-6 Selectively Regulate Neutrophil Function in Vitro

1995 • 64 citations

Interleukin-6 stimulates neutrophil production of platelet-activating factor

1996 • 57 citations

The soluble form of the IL-6 receptor (sIL-6Rα) is a potent growth factor for AIDS-associated Kaposi's sarcoma (KS) cells; the soluble form of gp130 is antagonistic for sIL-6Rα-induced AIDS-KS cell growth

1996 • 52 citations

Peptides derived from C-reactive protein inhibit neutrophil alveolitis.

1996 • 51 citations

Peptides generated from C-reactive protein by a neutrophil membrane protease. Amino acid sequence and effects of peptides on neutrophil oxidative metabolism and chemotaxis.

1990 • 51 citations

Monoclonal Antibodies to the Soluble Human IL-6 Receptor: Affinity Purification, ELISA, and Inhibition of Ligand Binding

1991 • 42 citations

Effects of C-reactive protein on human neutrophil granulocytes challenged with N-formyl-methionyl-leucyl-phenylalanine and platelet-activating factor

1989 • 40 citations

Generation of biologically active C-reactive protein peptides by a neutral protease on the membrane of phorbol myristate acetate-stimulated neutrophils.

1989 • 36 citations

Evaluation of soluble IL-6 receptor concentration in serum and epithelial lining fluid from patients with interstitial lung diseases

1995 • 34 citations

Activation of alveolar macrophage TNF and MCP-1 expression in vivo by a synthetic peptide of C-reactive protein

1996 • 28 citations

Serum soluble IL-6 receptor concentrations correlate with stages of multiple myeloma defined by serum beta 2-microglobulin and C-reactive protein.

1997 • 23 citations

Oncostatin M stimulates the expression and release of the IL-6 receptor in human hepatoma HepG2 cells.

1997 • 21 citations