Quantification of radiation induced DNA double-strand breaks in human fibroblasts by PFGE: testing the applicability of random breakage models

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

Initial Events in the Cellular Effects of Ionizing Radiations: Clustered Damage in DNA

1994 • 1,142 citations

Biochemistry of DNA Lesions

1985 • 445 citations

High-LET radiations induce a large proportion of non-rejoining DNA breaks

1977 • 360 citations

The Role of DNA Single- and Double-Strand Breaks in Cell Killing by Ionizing Radiation

1998 • 322 citations

A random-walk/giant-loop model for interphase chromosomes.

1995 • 306 citations

Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus.

1995 • 284 citations

Some Biochemical Consequences of the Spatial Distribution of Ionizing Radiation-Produced Free Radicals

1981 • 281 citations

Radiation Mutagenesis: The Initial DNA Lesions Responsible

1995 • 238 citations

Non-random distribution of DNA double-strand breaks induced by particle irradiation

1996 • 230 citations

Clusters of DNA Damage Induced by Ionizing Radiation: Formation of Short DNA Fragments. II. Experimental Detection

1996 • 229 citations

A review of dsb induction data for varying quality radiations

1998 • 228 citations

A Review of Studies of Ionizing Radiation-Induced Double-Strand Break Clustering

2001 • 190 citations

Monte Carlo Simulation of the Production of Short DNA Fragments by Low-Linear Energy Transfer Radiation Using Higher-Order DNA Models

1998 • 168 citations

Clusters of DNA induced by ionizing radiation: formation of short DNA fragments. I. Theoretical modeling.

1996 • 166 citations

DNA double-strand break distributions in X-ray and alpha-particle irradiated V79 cells: evidence for non-random breakage

1997 • 153 citations

Simulation of DNA fragment distributions after irradiation with photons

1999 • 142 citations

In CHEF Electrophoresis a Linear Induction of Dsb Corresponds to a Nonlinear Fraction of Extracted DNA with Dose

1990 • 139 citations

DNA damage induced by radiation of different linear energy transfer: initial fragmentation

2000 • 124 citations

Chromatin conformation in living cells: support for a zig-zag model of the 30 nm chromatin fiber 1 1Edited by T. Richmond

1998 • 113 citations

The Irradiation of V79 Mammalian Cells by Protons with Energies below 2 MeV

1989 • 99 citations

Radiation-Induced Heat-Labile Sites that Convert into DNA Double-Strand Breaks

2000 • 98 citations

Rejoining of DNA fragments produced by radiations of different linear energy transfer

2000 • 98 citations

Methods for the Quantification of DNA Double-Strand Breaks Determined from the Distribution of DNA Fragment Sizes Measured by Pulsed-Field Gel Electrophoresis

1995 • 92 citations

Analysis of DNA double strand breakage and repair using orthogonal field alternation gel electrophoresis

1987 • 92 citations

DNA DSB induction and rejoining in V79 cells irradiated with light ions: a constant field gel electrophoresis study

2000 • 85 citations

Nature of Lesions Formed by Ionizing Radiation

1998 • 69 citations

Induction and Rejoining of DNA Double-Strand Breaks in Normal Human Skin Fibroblasts after Exposure to Radiation of Different Linear Energy Transfer: Possible Roles of Track Structure and Chromatin Organization

2001 • 64 citations

A Polymer Model for the Structural Organization of Chromatin Loops and Minibands in Interphase Chromosomes

1998 • 60 citations

A Quantitative Model of DNA Fragments Generated by Ionizing Radiation, and Possible Experimental Applications

1991 • 53 citations

Damage pattern as a function of radiation quality and other factors

1999 • 52 citations

No dose-dependence of DNA double-strand break misrejoining following α-particle irradiation

2000 • 50 citations

Induction of DNA Double-strand Breaks in CHO-K1 Cells by Carbon Ions

1995 • 47 citations

A Component of DNA Double-strand Break Repair Is Dependent on the Spatial Orientation of the Lesions within the Higher-order Structures of Chromatin

1994 • 46 citations

The role of higher-order chromatin structure in the yield and distribution of DNA double-strand breaks in cells irradiated with X-rays or α-particles

2000 • 39 citations

Randomly distributed DNA double-strand breaks as measured by pulsed field gel electrophoresis: A series of explanatory calculations

1994 • 37 citations

Locations of radiation-produced DNA double strand breaks along chromosomes: a stochastic cluster process formalism

1999 • 34 citations

DNA Double-strand Breaks Induced by Low Energy Protons in V79 Cells

1994 • 33 citations

Higher-order structure of interphase chromosomes and radiation-induced chromosomal exchange aberrations

2000 • 28 citations

DNA Double-strand Break Induction in Yeast by X-rays and α-particles Measured by Pulsed-field Gel Electrophoresis

1993 • 28 citations

A polymer, random walk model for the size-distribution of large DNA fragments after high linear energy transfer radiation

2000 • 25 citations

A formalism for analysing large-scale clustering of radiation-induced breaks along chromosomes

1998 • 24 citations

Induction and Rejoining of Large DNA Fragments after Ion Irradiation

1999 • 23 citations

Formation and repair of DNA double-strand breaks in γ-irradiated K562 cells undergoing erythroid differentiation

2000 • 19 citations

Quantification of DNA damage by PFGE: development of an analytical approach to correct for the background distribution

2000 • 19 citations

Biophysical Analysis of Radiation Induced Initial DNA Fragmentation

2002 • 7 citations