Induction and Rejoining of DNA Double-Strand Breaks in Normal Human Skin Fibroblasts after Exposure to Radiation of Different Linear Energy Transfer: Possible Roles of Track Structure and Chromatin Organization

Biochemistry of DNA Lesions

1985 • 445 citations

High-LET radiations induce a large proportion of non-rejoining DNA breaks

1977 • 360 citations

Quantitative modelling of DNA damage using Monte Carlo track structure method

1999 • 322 citations

Track structure in radiation biology: theory and applications

1998 • 286 citations

Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus.

1995 • 284 citations

Periodicity of DNA folding in higher order chromatin structures.

1990 • 275 citations

The Initial Physical Damage Produced by Ionizing Radiations

1989 • 255 citations

Non-random distribution of DNA double-strand breaks induced by particle irradiation

1996 • 230 citations

Induction and Rejoining of DNA Double-strand Breaks in V79-4 Mammalian Cells Following γ- and α-irradiation

1993 • 186 citations

Monte Carlo Simulation of the Production of Short DNA Fragments by Low-Linear Energy Transfer Radiation Using Higher-Order DNA Models

1998 • 168 citations

Clusters of DNA induced by ionizing radiation: formation of short DNA fragments. I. Theoretical modeling.

1996 • 166 citations

Mutation and inactivation of mammalian cells by various ionising radiations

1977 • 160 citations

Inactivation of V79 cells by low-energy protons, deuterons and helium-3 ions

1996 • 157 citations

DNA double-strand break distributions in X-ray and alpha-particle irradiated V79 cells: evidence for non-random breakage

1997 • 153 citations

In CHEF Electrophoresis a Linear Induction of Dsb Corresponds to a Nonlinear Fraction of Extracted DNA with Dose

1990 • 139 citations

Clusters of DNA Damage Induced by Ionizing Radiation: Formation of Short DNA Fragments. I. Theoretical Modeling

1996 • 126 citations

DNA damage induced by radiation of different linear energy transfer: initial fragmentation

2000 • 124 citations

Rejoining of Double Strand Breaks in Normal Human and Ataxia-telangiectasia Fibroblasts after Exposure to⁶⁰Co γ-rays,²⁴¹Am α-particles or Bleomycin

1987 • 117 citations

Rejoining of DNA fragments produced by radiations of different linear energy transfer

2000 • 98 citations

Lethality of Heavy Ion-induced DNA Double-strand Breaks in Mammalian Cells

1993 • 84 citations

The quality of DNA double-strand breaks: A Monte Carlo simulation of the end-structure of strand breaks produced by protons and alpha particles

1995 • 70 citations

Joining of correct and incorrect DNA ends at double-strand breaks produced by high-linear energy transfer radiation in human fibroblasts.

1998 • 70 citations

Rejoining of DNA double-strand breaks induced by accelerated nitrogen ions

1996 • 56 citations

Joining of Correct and Incorrect DNA Ends at Double-Strand Breaks Produced by High-Linear Energy Transfer Radiation in Human Fibroblasts

1998 • 52 citations

Direct Comparison of Biological Effectiveness of Protons and Alpha-particles of the Same LET. II. Mutation Induction at the HPRT Locus in V79 Cells

1992 • 51 citations

No dose-dependence of DNA double-strand break misrejoining following α-particle irradiation

2000 • 50 citations

Higher-Order Chromatin Structure-Dependent Repair of DNA Double-Strand Breaks: Involvement of the V(D)J Recombination Double-Strand Break Repair Pathway

1998 • 37 citations

The effect of track structure on the induction of chromosomal aberrations in murine cells

1998 • 26 citations

A formalism for analysing large-scale clustering of radiation-induced breaks along chromosomes

1998 • 24 citations

Induction and Rejoining of Large DNA Fragments after Ion Irradiation

1999 • 23 citations

Estimation of double-strand break quality based on track-structure calculations

1993 • 20 citations

The effect of dimethyl sulphoxide on the induction and repair of double-strand breaks in human cells after irradiation with gamma-rays and accelerated ions: rapid or slow repair may depend on accessibility of breaks in chromatin of different compactness

2000 • 18 citations

Rejoining of clustered double-strand breaks induced by high-LET radiation.

1997 • 2 citations