DNA Double-strand Break Induction in Yeast by X-rays and α-particles Measured by Pulsed-field Gel Electrophoresis

Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis

1984 • 2,847 citations

International Journal of Radiation Biology

1959 • 1,730 citations

Separation of Large DNA Molecules by Contour-Clamped Homogeneous Electric Fields

1986 • 1,525 citations

An electrophoretic karyotype for yeast.

1985 • 787 citations

The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control

1976 • 518 citations

Genetic map of Saccharomyces cerevisiae

1980 • 394 citations

Mechanisms of chromosomal aberration production III. Chemicals and ionizing radiation

1974 • 363 citations

Enzymatic Restriction of Mammalian Cell DNA Using Pvu II and Bam H1: Evidence for the Double-strand Break Origin of Chromosomal Aberrations

1984 • 313 citations

Evidence for DNA Double-Strand Breaks as the Critical Lesions in Yeast Cells Irradiated with Sparsely or Densely Ionizing Radiation under Oxic or Anoxic Conditions

1981 • 271 citations

Genetic map of Saccharomyces cerevisiae, edition 9

1985 • 248 citations

Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations

1978 • 209 citations

Size variation in chromosomes from independent cultured isolates of Plasmodium falciparum

1985 • 201 citations

DNA Double Strand Breaks in Ehrlich Ascites Tumour Cells at Low Doses of X-rays. II. Can Cell Death be Attributed to Double Strand Breaks?

1982 • 200 citations

Separation of very large DNA molecules by gel electrophoresis

1978 • 199 citations

Comparison of Lethality and Chromosomal Damage Induced by X-Rays in Synchronized Chinese Hamster Cells In Vitro

1970 • 189 citations

DNA Double-strand Break Repair Determines the RBE of α-particles

1988 • 172 citations

Chromosome-Sized DNA Molecules of Plasmodium falciparum

1985 • 153 citations

CHEF Electrophoresis, a Sensitive Technique for the Determination of DNA Double-strand Breaks

1989 • 150 citations

Enzymatic Restriction of Mammalian Cell DNA: Evidence for Double-strand Breaks as Potentially Lethal Lesions

1985 • 146 citations

Genetic map of Saccharomyces cerevisiae, edition 9.

1985 • 137 citations

Rejoining of Double Strand Breaks in Normal Human and Ataxia-telangiectasia Fibroblasts after Exposure to⁶⁰Co γ-rays,²⁴¹Am α-particles or Bleomycin

1987 • 117 citations

The Relationship between Radiation-induced DNA Double-strand Breaks and Cell Kill in Hamster V79 Fibroblasts Irradiated with 250 kVp X-rays, 2·3 MeV Neutrons or²³⁸Pu α-particles

1987 • 116 citations

Electronic imaging system for direct and rapid quantitation of fluorescence from electrophoretic gels: Application to ethidium bromide-stained DNA

1987 • 115 citations

The formation of radiation-induced dna breaks: The ratio of double-strand breaks to single-strand breaks

1985 • 93 citations

Analysis of DNA double strand breakage and repair using orthogonal field alternation gel electrophoresis

1987 • 92 citations

The Influence of Oxygen on the Yield of DNA Double-Strand Breaks in X-Irradiated Escherichia coli K-12

1975 • 76 citations

The Influence of Oxygen on the Survival and Yield of DNA Double-strand Breaks in Irradiated Yeast Cells

1979 • 68 citations

Direct Comparison of Biological Effectiveness of Protons and Alpha-particles of the Same LET. III. Initial Yield of DNA Double-strand Breaks in V79 Cells

1992 • 67 citations

Ionizing radiation damage to DNA: Molecular aspects

1989 • 60 citations

The Dose—response for Low-LET Radiation-induced DNA Double-strand Breakage: Methods of Measurement and Implications for Radiation Action Models

1988 • 55 citations

A Quantitative Model of DNA Fragments Generated by Ionizing Radiation, and Possible Experimental Applications

1991 • 53 citations

Similar responses to ionizing radiation of fungal and vertebrate cells and the importance of DNA double-strand breaks

1978 • 53 citations

Direct Comparison of Biological Effectiveness of Protons and Alpha-particles of the Same LET. II. Mutation Induction at the HPRT Locus in V79 Cells

1992 • 51 citations

A Comparative Study of Rejoining of DNA Double-strand Breaks in Yeast Irradiated with 3·5 MeV α-particles or with 30 MeV Electrons

1990 • 50 citations

Photographic quantitation of DNA in gel electrophoresis

1977 • 49 citations

The Involvement of Indirect Effects in Cell-killing and DNA Double-strand Breakage in γ-irradiatedEscherichia ColiK-12

1976 • 44 citations

Isolation and Characterization of Mutants of Saccharomyces cerevisiae Auxotrophic and Conditionally Auxotrophic for 5′ -dTMP

1974 • 36 citations

Quantitative fluorescence of DNA-intercalated ethidium bromide on agarose gels

1989 • 34 citations

The Rejoining of DNA Double-strand Breaks Following Irradiation with²³⁸Pu α-particles: Evidence for a Fast Component of Repair as Measured by Neutral Filter Elution

1990 • 30 citations

Two-dimensional, computer-controlled film scanner: Quantitation of fluorescence from ethidium bromide-stained DNA gels

1984 • 29 citations

Measurement of Double-Strand Breaks in Chinese Hamster Cell DNA by Neutral Filter Elution: Calibration by 125 I Decay

1988 • 28 citations

The use of charge‐coupled devices in the quantitative evaluation of images, on photographic film or membranes, obtained following electrophoretic separation of DNA fragments

1990 • 21 citations

X-Ray-Induced Dominant Lethality and Chromosome Breakage and Repair in a Radiosensitive Strain of Yeast

1975 • 20 citations

Application of Pulsed Field Gel Electrophoresis to Determine γ-ray-induced Double-strand Breaks in Yeast Chromosomal Molecules

1993 • 17 citations

Interpretation of the dose and LET dependence of RBE values for lethal lesions in yeast cells.

1984 • 15 citations

Interpretation of the Dose and LET Dependence of RBE Values for Lethal Lesions in Yeast Cells

1984 • 15 citations

Analysis of the Inversion Effect in Pulsed Field Gel Electrophoresis by a Two-Dimensional Contour-Clamped Homogeneous Electric Field System

1993 • 11 citations

Electrophoretic separation of nucleic acids: Evaluation by video and photographic densitometry

1990 • 9 citations