Nature of Lesions Formed by Ionizing Radiation

The Chemical Basis of Radiation Biology

1987 • 1,843 citations

The chemical basis of radiation biology

1987 • 1,788 citations

Normal oxidative damage to mitochondrial and nuclear DNA is extensive.

1988 • 1,709 citations

Reconstruction in vivo of Irradiated Escherichia coli Deoxyribonucleic Acid; the Rejoining of Broken Pieces

1966 • 727 citations

Radioprotectors and anticarcinogens

1983 • 613 citations

The Complexity of DNA Damage: Relevance to Biological Consequences

1994 • 604 citations

Biochemistry of DNA Lesions

1985 • 445 citations

gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini.

1983 • 319 citations

Chemical Radioprotection and Radiosensitization of Mammalian Cells Growingin Vitro

2012 • 316 citations

Mammalian Cells Are Not Killed by DNA Single-Strand Breaks Caused by Hydroxyl Radicals from Hydrogen Peroxide

1985 • 305 citations

Protection of DNA Molecules of Cultured Mammalian Cells from Radiation-induced Single-strand Scissions by Various Alcohols and SH Compounds

1972 • 297 citations

Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column.

1992 • 292 citations

Some Biochemical Consequences of the Spatial Distribution of Ionizing Radiation-Produced Free Radicals

1981 • 281 citations

Constraints on Energy Deposition and Target Size of Multiply Damaged Sites Associated with DNA Double-strand Breaks

1992 • 271 citations

Sites and structure of gamma radiation-induced DNA strand breaks.

1982 • 249 citations

Chemical Radioprotection and Radiosensitization of Mammalian Cells Growing in Vitro

1973 • 242 citations

Molecular Mechanisms of Radiation-Induced Damage to Nucleic Acids

1975 • 240 citations

Radiation Mutagenesis: The Initial DNA Lesions Responsible

1995 • 238 citations

The Chemical Consequences of Radiation Damage to DNA

1993 • 225 citations

Radiation-Induced DNA Damage as a Function of Hydration: I. Release of Unaltered Bases

1992 • 201 citations

Primary Free Radical Processes in DNA

1993 • 197 citations

Single- and Double-Strand Break Formation in DNA Irradiated in Aqueous Solution: Dependence on Dose and OH Radical Scavenger Concentration

1987 • 196 citations

Radiation Chemical Mechanisms of Single- and Double-Strand Break Formation in Irradiated SV40 DNA

1991 • 186 citations

Variation of Single-Strand Break Yield with Scavenger Concentration for Plasmid DNA Irradiated in Aqueous Solution

1993 • 186 citations

Induction and Rejoining of DNA Double-strand Breaks in V79-4 Mammalian Cells Following γ- and α-irradiation

1993 • 186 citations

DNA Double-strand Break Repair Determines the RBE of α-particles

1988 • 172 citations

Radiation and hydrogen peroxide induced free radical damage to DNA.

1987 • 169 citations

Yields of Radiation-induced Base Products in DNA: Effects of DNA Conformation and Gassing Conditions

1990 • 168 citations

Repair of X-Ray Damage to the Deoxyribonucleic Acid in Micrococcus radiodurans

1966 • 162 citations

Hydrogen Peroxide-Induced Base Damage in Deoxyribonucleic Acid

1990 • 134 citations

The mechanism of free base formation from DNA by bleomycin. A proposal based on site specific tritium release from Poly(dA.dU).

1983 • 133 citations

The Reaction of Oxygen with Radiation-induced Free Radicals in DNA and Related Compounds

1970 • 131 citations

Repair of intrinsic DNA lesions

1990 • 126 citations

Yields of Radiation-induced Main Chain Scission of Poly U in Aqueous Solution: Strand Break Formation Via Base Radicals

1984 • 125 citations

Radiation-Induced DNA Damage as a Function of Hydration. II. Base Damage from Electron-Loss Centers

1996 • 111 citations

The Action ofEscherichia coliEndonuclease III on Multiply Damaged Sites in DNA

1995 • 110 citations

The Effect of Dimethyl Sulfoxide on the Induction of DNA Double-Strand Breaks in V79-4 Mammalian Cells by Alpha Particles

1995 • 106 citations

DNA Base Damage in Chromatin of γ-Irradiated Cultured Human Cells

1992 • 105 citations

Base Liberation and Concomitant Reactions in Irradiated DNA Solutions

1971 • 105 citations

Effects of ionizing radiation on deoxyribonucleic acid and related systems. Part 1. The rôle of oxygen

1984 • 99 citations

Strand breaks, base release, and postirradiation changes in DNA gamma-irradiated in dilute O2-saturated aqueous solution.

1976 • 95 citations

Chemical Nature of Chain Breaks Produced in DNA by X-Irradiation in Vitro

1970 • 88 citations

Measurement of DNA Damage by Electrons with Energies between 25 and 4000 EV

1993 • 87 citations

The Role of Oxygen Oxygen and Living Processes: An Interdisciplinary Approach Daniel Gilbert

1982 • 86 citations

Yield of Single-Strand Breaks Due to Attack on DNA by Scavenger-Derived Radicals

1994 • 82 citations

End group determination in γ-irradiated DNA

1970 • 81 citations

Use of repair endonucleases to characterize DNA damage induced by reactive oxygen species in cellular and cell-free systems

1993 • 79 citations

Polyamine-Induced Compaction and Aggregation of DNA: A Major Factor in Radioprotection of Chromatin under Physiological Conditions

1996 • 78 citations

Modulation of Radiation-induced Chromosome Aberrations by DMSO, an OH Radical Scavenger. 1: Dose—response Studies in Human Lymphocytes Exposed to 220 kV X-rays

1988 • 76 citations

Free Radical-Induced Double Base Lesions

1995 • 72 citations

DNA Base Damage Generatedin Vivoin Hepatic Chromatin of Mice Upon Whole Body γ-irradiation

1993 • 71 citations

Where Are the Sugar Radicals in Irradiated DNA?

1997 • 69 citations

Detecting DNA damage

1993 • 65 citations

The Early Effects of Radiation on DNA

1991 • 65 citations

DETECTING DNA DAMAGE

1993 • 63 citations

Strand Breaks, Base Release, and Postirradiation Changes in DNA g-Irradiated in Dilute O 2 -Saturated Aqueous Solution

1976 • 59 citations

Relationships Between Cell Killing, Mutation Induction and DNA Damage in X-irradiated V79 Cells: The Influence of Oxygen and DMSO

1991 • 54 citations

Laser-induced photoionization and single-strand break formation for polynucleotides and single-stranded DNA in aqueous solution: model studies for the direct effect of high energy radiation on DNA

1987 • 53 citations

DNA Strand Breakage Is Correlated with Unaltered Base Release after Gamma Irradiation

1995 • 51 citations

DNA Repair by Thiols in Air Shows Two Radicals Make a Double-Strand Break

1995 • 49 citations

Ionizing Radiation Causes Greater DNA Base Damage in Radiation-Sensitive Mutant M10 Cells Than in Parent Mouse Lymphoma L5178Y Cells

1994 • 49 citations

Rejoining of Gamma-Radiation-Induced Single-Strand Breaks in Plasmid DNA by Human Cell Extracts: Dependence on the Concentration of the Hydroxyl Radical Scavenger, Tris

1996 • 49 citations

Linear Energy Transfer and Track Structure

1993 • 49 citations

Southern Blot and Polymerase Chain Reaction Exon Analyses of HPRT - Mutations Induced by Radon and Radon Progeny

1994 • 47 citations

Malondialdehyde precursors in gamma-irradiated DNA, deoxynucleotides and deoxynucleosides

1985 • 45 citations

Radiosensitization of Mammalian Cells by Misonidazole and Oxygen: DNA Damage Exposed by Micrococcus luteus Enzymes

1979 • 38 citations

Alkali-labile Sites in Biologically Active DNA: Comparison of Radiation Induced Potential Breaks and Apurinic Sites

1981 • 35 citations

Mechanism of radiation-induced strand break formation in DNA and polynucleotides

1986 • 24 citations

PHOTOREACTIONS OF TRIS(2,2′‐BIPYRIDYL)‐RUTHENIUM(II) WITH PEROXYDISULFATE IN DEOXYGENATED AQUEOUS SOLUTION IN THE PRESENCE OF NUCLEIC ACID COMPONENTS, POLYNUCLEOTIDES, AND DNA*

1988 • 24 citations

Abnormal Distribution of Double Strand Breaks in DNA after Direct Action of Ionizing Energy

1985 • 23 citations

Biological Consequences of Non-Homogeneous Energy Deposition by Ionising Radiation

1994 • 21 citations

OH Radical-Induced Main-Chain Scission of Poly(Ribonucleic Acids) under Anoxic Conditions

1983 • 20 citations

Resolution and conservation of mismatches in DNA end joining

1994 • 19 citations

Production and Repair of DNA Damage in Mammalian Cells

1990 • 19 citations

Cerenkov Light and the Production of Photoreactivatable Damage in X-irradiatedE. Coli

1981 • 17 citations

Abnormal Distribution of Double Strand Breaks in DNA after Direct Action of Ionizing Energy

1985 • 9 citations

The Production of Alkali-labile Lesions in X-irradiated PM2 DNA

1978 • 7 citations

Secondary Reaction in Irradiated Nucleotides: Possible Significance for Chemical “Repair” Mechanisms

1989 • 5 citations

Radiation Induced Clustered Damage in DNA

1989 • 2 citations

A comparison of the fast kinetics of radiation-induced DNA lesions from low and high LET radiations: Clustered damage and dependence on OER

1995 • 1 citations