Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

2002 • 1,771 citations

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

1999 • 1,753 citations

Four deaths and a funeral: from caspases to alternative mechanisms

2001 • 1,605 citations

The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors

2002 • 1,352 citations

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

2001 • 1,327 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia

1997 • 1,020 citations

Heat-shock protein 70 antagonizes apoptosis-inducing factor

2001 • 846 citations

Poly(ADP-ribose) polymerase: a molecular nick-sensor

1994 • 790 citations

Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

2003 • 758 citations

Two Distinct Pathways Leading to Nuclear Apoptosis

2000 • 737 citations

Role of poly(ADP-ribose) synthetase in inflammation and ischaemia–reperfusion

1998 • 687 citations

Ischemic Brain Injury is Mediated by the Activation of Poly(ADP-Ribose)Polymerase

1997 • 624 citations

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

1995 • 600 citations

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

1999 • 597 citations

The harlequin mouse mutation downregulates apoptosis-inducing factor

2002 • 595 citations

Poly(ADP-ribose) Binds to Specific Domains in DNA Damage Checkpoint Proteins

2000 • 532 citations

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?

2000 • 527 citations

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

2002 • 485 citations

Patterns of cell death.

1988 • 470 citations

Chromatin Loosening by Poly(ADP)-Ribose Polymerase (PARP) at Drosophila Puff Loci

2003 • 437 citations

Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization

2003 • 434 citations

Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease

2003 • 400 citations

NADH Oxidase Activity of Mitochondrial Apoptosis-inducing Factor

2001 • 382 citations

PARP-1, a determinant of cell survival in response to DNA damage

2003 • 376 citations

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase

1997 • 376 citations

Mechanisms of AIF-Mediated Apoptotic DNA Degradation in Caenorhabditis elegans

2002 • 375 citations

DNA binding is required for the apoptogenic action of apoptosis inducing factor

2002 • 342 citations

The world according to PARP

2001 • 315 citations

Intra-mitochondrial Poly(ADP-ribosylation) Contributes to NAD+ Depletion and Cell Death Induced by Oxidative Stress

2003 • 303 citations

Poly(ADP-ribose) polymerase: killer or conspirator? The ‘suicide hypothesis’ revisited

2002 • 294 citations

Involvement of apoptosis‐inducing factor in neuronal death after hypoxia‐ischemia in the neonatal rat brain

2003 • 288 citations

Intranuclear localization of apoptosis‐inducing factor (AIF) and large scale dna fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite

2002 • 249 citations

Dominant cell death induction by extramitochondrially targeted apoptosis‐inducing factor

2001 • 244 citations

Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death.

1998 • 218 citations

TANK2, a New TRF1-associated Poly(ADP-ribose) Polymerase, Causes Rapid Induction of Cell Death upon Overexpression

2001 • 215 citations

Poly(ADP-Ribose) Synthetase Activation Mediates Mitochondrial Injury During Oxidant-Induced Cell Death

1998 • 204 citations

Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria

2001 • 202 citations

Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells

2003 • 200 citations

Poly(ADP-ribose) Polymerase-1 in the Nervous System

2000 • 196 citations

Poly(ADP-ribose) polymerase-1 and apoptosis inducing factor in neurotoxicity

2003 • 193 citations

Dueling Activities of AIF in Cell Death versus Survival

2002 • 186 citations

The crystal structure of the mouse apoptosis-inducing factor AIF

2002 • 178 citations

Regulation of microglial expression of integrins by poly(ADP-ribose) polymerase-1

2001 • 173 citations

Critical role of photoreceptor apoptosis in functional damage after retinal detachment

2002 • 142 citations

Apoptosis‐Inducing Factor Mediates Microglial and Neuronal Apoptosis Caused by Pneumococcus

2001 • 131 citations

Poly(ADP-Ribose) Polymerase Impairs Early and Long-Term Experimental Stroke Recovery

2002 • 129 citations

Apoptosis Inducing Factor and PARP‐Mediated Injury in the MPTP Mouse Model of Parkinson's Disease

2003 • 125 citations

Roles of poly(ADP-ribosyl)ation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1

2000 • 125 citations

CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation

2003 • 119 citations

Transcriptional Repression by Binding of Poly(ADP-ribose) Polymerase to Promoter Sequences

2002 • 117 citations

A proteomic approach to the identification of heterogeneous nuclear ribonucleoproteins as a new family of poly(ADP-ribose)-binding proteins

2003 • 113 citations

Centromere Proteins Cenpa, Cenpb, and Bub3 Interact with Poly(ADP-ribose) Polymerase-1 Protein and Are Poly(ADP-ribosyl)ated

2002 • 111 citations

Poly(ADP-ribose) Polymerase Mediates the Suicide Response to Massive DNA Damage: Studies in Normal and DNA-repair Defective Cells

2020 • 106 citations

Metabolic consequences of DNA damage: DNA damage induces alterations in glucose metabolism by activation of poly(ADP-ribose) polymerase

1986 • 103 citations

HSP72 inhibits apoptosis-inducing factor release in ATP-depleted renal epithelial cells

2003 • 83 citations