A Novel, Multifunctional c-Cbl Binding Protein in Insulin Receptor Signaling in 3T3-L1 Adipocytes

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Protein modules and signalling networks

1995 • 2,447 citations

The insulin signaling system.

1994 • 1,733 citations

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1991 • 1,590 citations

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

1994 • 1,240 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

Role of IRS-2 in insulin and cytokine signalling

1995 • 843 citations

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 • 705 citations

A Grb2-associated docking protein in EGF- and insulin-receptor signalling

1996 • 674 citations

Mitogen-activated Protein Kinase Kinase Inhibition Does Not Block the Stimulation of Glucose Utilization by Insulin

1995 • 395 citations

Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade.

1994 • 329 citations

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.

1994 • 299 citations

Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts.

1993 • 257 citations

The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif.

1991 • 234 citations

Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.

1994 • 232 citations

Cloning of ligand targets: Systematic isolation of SH3 domain-containing proteins

1996 • 224 citations

Acquisition of increased hormone sensitivity during in vitro adipocyte development.

1977 • 221 citations

Differential Signaling by Insulin Receptor Substrate 1 (IRS-1) and IRS-2 in IRS-1-Deficient Cells

1997 • 212 citations

Tyrosine Phosphorylation of the c-cbl Proto-oncogene Protein Product and Association with Epidermal Growth Factor (EGF) Receptor upon EGF Stimulation

1995 • 202 citations

Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.

1994 • 200 citations

The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120

1995 • 186 citations

The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutively Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells

1995 • 179 citations

Involvement of She in Insulin- and Epidermal Growth Factor-Induced Activation of p21^ras

1994 • 174 citations

Tyrosine Phosphorylation and Translocation of the c-Cbl Protein after Activation of Tyrosine Kinase Signaling Pathways

1995 • 171 citations

Tyrosine Phosphorylation of Cbl upon Epidermal Growth Factor (EGF) Stimulation and Its Association with EGF Receptor and Downstream Signaling Proteins

1996 • 166 citations

Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes

1997 • 155 citations

Coupling of the c-Cbl protooncogene product to ErbB-1/EGF-receptor but not to other ErbB proteins.

1996 • 153 citations

Activation of Mitogen-activated Protein Kinase and Phosphatidylinositol 3′-Kinase Is Not Sufficient for the Hormonal Stimulation of Glucose Uptake, Lipogenesis, or Glycogen Synthesis in 3T3-L1 Adipocytes

1995 • 148 citations

Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene

1994 • 148 citations

Diverse signaling pathways in the cellular actions of insulin

1996 • 144 citations

p120 Is a Cytosolic Adapter Protein That Associates with Phosphoinositide 3-Kinase in Response to Epidermal Growth Factor in PC12 and Other Cells

1996 • 143 citations

The Acquisition of Increased Insulin-responsive Hexose Transport in 3T3-L1 Adipocytes Correlates with Expression of a Novel Transporter Gene

1989 • 137 citations

Interactions of Cbl with Two Adaptor Proteins, Grb2 and Crk, upon T Cell Activation

1996 • 136 citations

Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction.

1994 • 126 citations

The Product of the cbl Oncogene Forms Stable Complexes In Vivo with Endogenous Crk in a Tyrosine Phosphorylation-Dependent Manner

1996 • 117 citations

The truncation that generated the v-cbl oncogene reveals an ability for nuclear transport, DNA binding and acute transformation.

1993 • 109 citations

Insulin-Stimulated Disassociation of the SOS-Grb2 Complex

1995 • 107 citations

Cellular proteins binding to the first Src homology 3 (SH3) domain of the proto-oncogene product c-Crk indicate Crk-specific signaling pathways.

1995 • 100 citations

Expression and compartmentalization of caveolin in adipose cells: coordinate regulation with and structural segregation from GLUT4.

1995 • 97 citations

The Proto-oncogene Product p120 Links c-Src and Phosphatidylinositol 3′-Kinase to the Integrin Signaling Pathway

1997 • 94 citations

Shc Isoform-specific Tyrosine Phosphorylation by the Insulin and Epidermal Growth Factor Receptors

1995 • 71 citations

Nerve Growth Factor Stimulates the Tyrosine Phosphorylation of Endogenous Crk-II and Augments Its Association with p130Cas in PC-12 Cells

1996 • 64 citations

Association of Activated Phosphatidylinositol 3-Kinase with p120cbl in Antigen Receptor-ligated B Cells

1995 • 64 citations

Activation of the Ras/mitogen-activated protein kinase signaling pathway alone is not sufficient to induce glucose uptake in 3T3-L1 adipocytes.

1994 • 64 citations

Interactions between Src Homology (SH) 2/SH3 Adapter Proteins and the Guanylnucleotide Exchange Factor SOS Are Differentially Regulated by Insulin and Epidermal Growth Factor

1996 • 42 citations

Isolation and characterisation of porcine sorbin

1991 • 27 citations

Deleted Work

1955 • 0 citations