The inflammasome: a danger sensing complex triggering innate immunity

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

The Inflammasome

2002 • 5,445 citations

Gout-associated uric acid crystals activate the NALP3 inflammasome

2006 • 4,851 citations

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines

2005 • 3,466 citations

Cryopyrin activates the inflammasome in response to toxins and ATP

2006 • 2,874 citations

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

2004 • 1,769 citations

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

2004 • 1,663 citations

Molecular identification of a danger signal that alerts the immune system to dying cells

2003 • 1,649 citations

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

2007 • 1,352 citations

Pannexin-1 mediates large pore formation and interleukin-1β release by the ATP-gated P2X7 receptor

2006 • 1,343 citations

Intracellular pattern recognition receptors in the host response

2006 • 1,170 citations

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

2006 • 1,104 citations

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

2006 • 1,099 citations

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

2006 • 1,097 citations

NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease

2005 • 970 citations

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

2007 • 953 citations

Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1

2006 • 947 citations

Nod-like proteins in immunity, inflammation and disease

2006 • 866 citations

Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation

2006 • 857 citations

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

2006 • 839 citations

Inflammatory caspases and inflammasomes: master switches of inflammation

2006 • 784 citations

ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages

2006 • 733 citations

Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

1994 • 725 citations

A pilot study of IL-1 inhibition by anakinra in acute gout

2007 • 717 citations

Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA

2006 • 681 citations

Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation

2007 • 680 citations

NALP1in Vitiligo-Associated Multiple Autoimmune Disease

2007 • 602 citations

Identification of Bacterial Muramyl Dipeptide as Activator of the NALP3/Cryopyrin Inflammasome

2004 • 568 citations

The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1

2002 • 543 citations

Flagellin-Deficient Legionella Mutants Evade Caspase-1- and Naip5-Mediated Macrophage Immunity

2006 • 527 citations

Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling

2007 • 522 citations

The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection

2006 • 517 citations

The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes

2007 • 503 citations

Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response

2006 • 497 citations

Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival

2006 • 497 citations

Interleukin‐1β, Interleukin‐18, and the Interleukin‐1β Converting Enzyme^a

1998 • 495 citations

Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans

2006 • 455 citations

Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling

2007 • 445 citations

Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1

2001 • 439 citations

A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses

2007 • 412 citations

Activation of the IL-1β-Processing Inflammasome Is Involved in Contact Hypersensitivity

2007 • 392 citations

Innate immunity against Francisella tularensis is dependent on the ASC/caspase-1 axis

2005 • 389 citations

PYPAF7, a Novel PYRIN-containing Apaf1-like Protein That Regulates Activation of NF-κB and Caspase-1-dependent Cytokine Processing

2002 • 362 citations

CATERPILLER: A Novel Gene Family Important in Immunity, Cell Death, and Diseases

2004 • 351 citations

Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria

2007 • 343 citations

Plant innate immunity – direct and indirect recognition of general and specific pathogen-associated molecules

2003 • 334 citations

Type I interferon signaling is required for activation of the inflammasome during Francisella infection

2007 • 311 citations

Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1

2007 • 310 citations

Pannexin-1 Couples to Maitotoxin- and Nigericin-induced Interleukin-1β Release through a Dye Uptake-independent Pathway

2006 • 289 citations

Potassium-inhibited processing of IL-1 beta in human monocytes.

1995 • 282 citations

Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila

2002 • 280 citations

Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF‐κB and caspase‐1

2002 • 267 citations

The HSP90 chaperone complex, an emerging force in plant development and phenotypic plasticity

2004 • 199 citations

The inflammasome in pathogen recognition and inflammation

2007 • 165 citations

SGT1 is essential for Nod1 activation

2007 • 146 citations

MDP-induced interleukin-1β processing requires Nod2 and CIAS1/NALP3

2007 • 140 citations

The Nod-Like Receptor Family Member Naip5/Birc1e Restricts Legionella pneumophila Growth Independently of Caspase-1 Activation

2007 • 111 citations

Plant Immunity: The Origami of Receptor Activation

2004 • 106 citations

A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development

2002 • 104 citations

Maturation and Release of Interleukin-1β by Lipopolysaccharide-primed Mouse Schwann Cells Require the Stimulation of P2X7 Receptors

2003 • 103 citations

Resistance gene signaling in plants — complex similarities to animal innate immunity

2003 • 97 citations

The Systemic Autoinflammatory Diseases: Inborn Errors of the Innate Immune System

2006 • 84 citations

Francisella Tularensis: Activation of the Inflammasome

2007 • 47 citations