Resistance gene signaling in plants — complex similarities to animal innate immunity

CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein

1990 • 4,041 citations

Plant pathogens and integrated defence responses to infection

2001 • 3,806 citations

Current Status of the Gene-For-Gene Concept

1971 • 3,023 citations

The leucine-rich repeat as a protein recognition motif

2001 • 1,584 citations

RIN4 Interacts with Pseudomonas syringae Type III Effector Molecules and Is Required for RPM1-Mediated Resistance in Arabidopsis

2002 • 1,139 citations

Clusters of Resistance Genes in Plants Evolve by Divergent Selection and a Birth-and-Death Process

1998 • 1,004 citations

Different requirements for EDS1 and NDR1 by disease resistance genes define at least two R gene-mediated signaling pathways in Arabidopsis

1998 • 765 citations

The nematode resistance geneMiof tomato confers resistance against the potato aphid

1998 • 731 citations

Lipopolysaccharide recognition: CD14, TLRs and the LPS-activation cluster

2002 • 715 citations

The evolution and genetics of innate immunity

2001 • 665 citations

EDS1 , an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases

1999 • 619 citations

Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4

2001 • 611 citations

A Single Amino Acid Difference Distinguishes Resistant and Susceptible Alleles of the Rice Blast Resistance Gene Pi-ta

2000 • 600 citations

The RAR1 Interactor SGT1, an Essential Component of R Gene-Triggered Disease Resistance

2002 • 593 citations

Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation

2002 • 583 citations

The NB-ARC domain: a novel signalling motif shared by plant resistance gene products and regulators of cell death in animals

1998 • 582 citations

Hsp90: Chaperoning signal transduction

2001 • 569 citations

Tomato Prf Is a Member of the Leucine-Rich Repeat Class of Plant Disease Resistance Genes and Lies Embedded within the Pto Kinase Gene Cluster

1996 • 558 citations

Characterization of eds1, a mutation in Arabidopsis suppressing resistance to Peronospora parasitica specified by several different RPP genes.

1996 • 516 citations

Broad-Spectrum Mildew Resistance in Arabidopsis thaliana Mediated by RPW8

2001 • 460 citations

Phosphorylation of human progesterone receptors at serine-294 by mitogen-activated protein kinase signals their degradation by the 26S proteasome

2000 • 444 citations

PAD4 Functions Upstream from Salicylic Acid to Control Defense Responses in Arabidopsis

1998 • 430 citations

Early auxin-induced genes encode short-lived nuclear proteins.

1994 • 430 citations

Interaction between domains of a plant NBS-LRR protein in disease resistance-related cell death

2002 • 429 citations

Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila

1999 • 429 citations

Ubiquitin ligase-associated protein SGT1 is required for host and nonhost disease resistance in plants

2002 • 412 citations

Regulatory Role of SGT1 in Early R Gene-Mediated Plant Defenses

2002 • 411 citations

A Tomato Cysteine Protease Required for Cf-2 -Dependent Disease Resistance and Suppression of Autonecrosis

2002 • 404 citations

Characterization of the tomato Cf-4 gene for resistance to Cladosporium fulvum identifies sequences that determine recognitional specificity in Cf-4 and Cf-9.

1997 • 403 citations

The Arabidopsis thaliana RPM1 disease resistance gene product is a peripheral plasma membrane protein that is degraded coincident with the hypersensitive response

1998 • 392 citations

NDR1 , a Pathogen-Induced Component Required for Arabidopsis Disease Resistance

1997 • 377 citations

SGT1 Encodes an Essential Component of the Yeast Kinetochore Assembly Pathway and a Novel Subunit of the SCF Ubiquitin Ligase Complex

1999 • 376 citations

Regulation of Transcriptional Activation Domain Function by Ubiquitin

2001 • 363 citations

A Novel Class of Eukaryotic Zinc-Binding Proteins Is Required for Disease Resistance Signaling in Barley and Development in C. elegans

1999 • 345 citations

Role of SCF Ubiquitin-Ligase and the COP9 Signalosome in the N Gene–Mediated Resistance Response to Tobacco mosaic virus

2002 • 329 citations

Cutting Edge: Lipopolysaccharide Induces Physical Proximity Between CD14 and Toll-Like Receptor 4 (TLR4) Prior to Nuclear Translocation of NF-κB

2000 • 322 citations

Six Amino Acid Changes Confined to the Leucine-Rich Repeat β-Strand/β-Turn Motif Determine the Difference between the P and P2 Rust Resistance Specificities in Flax

2001 • 242 citations

Downy mildew (Peronospora parasitica) resistance genes in Arabidopsis vary in functional requirements for NDR1, EDS1, NPR1 and salicylic acid accumulation

2000 • 239 citations

RAR1 and NDR1 Contribute Quantitatively to Disease Resistance in Arabidopsis, and Their Relative Contributions Are Dependent on the R Gene Assayed

2002 • 236 citations

COP9 signalosome revisited: a novel mediator of protein degradation

2001 • 221 citations

Arabidopsis SGT1b Is Required for Defense Signaling Conferred by Several Downy Mildew Resistance Genes

2002 • 217 citations

Mechanism of Ribonuclease Inhibition by Ribonuclease Inhibitor Protein Based on the Crystal Structure of its Complex with Ribonuclease A

1996 • 208 citations

Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide

1999 • 202 citations

Balancing selection favors guarding resistance proteins

2002 • 193 citations

Evidence for a Role of the N Terminus and Leucine-Rich Repeat Region of the Mi Gene Product in Regulation of Localized Cell Death

2000 • 181 citations

Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells.

1996 • 179 citations

Function of the ubiquitin–proteasome pathway in auxin response

2000 • 176 citations

Relationship between Active Oxygen Species, Lipid Peroxidation, Necrosis, and Phytoalexin Production Induced by Elicitins in Nicotiana

1996 • 147 citations

HSP40 Binding Is the First Step in the HSP90 Chaperoning Pathway for the Progesterone Receptor

2002 • 142 citations

An Evolutionarily Conserved Mediator of Plant Disease Resistance Gene Function Is Required for Normal Arabidopsis Development

2002 • 127 citations

Knowing the dancer from the dance: R-gene products and their interactions with other proteins from host and pathogen

2001 • 83 citations

Binding of Immunophilins to the 90 kDa Heat Shock Protein (hsp90) via a Tetratricopeptide Repeat Domain Is a Conserved Protein Interaction in Plants

1996 • 79 citations