CATERPILLER: A Novel Gene Family Important in Immunity, Cell Death, and Diseases

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Toll-Like Receptors

2003 • 6,127 citations

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

The Inflammasome

2002 • 5,445 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection

2003 • 2,325 citations

The immunological and genetic basis of inflammatory bowel disease

2003 • 1,766 citations

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

2004 • 1,663 citations

Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

2003 • 1,651 citations

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

2001 • 1,593 citations

Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

2003 • 1,527 citations

Large-scale analysis of the human and mouse transcriptomes

2002 • 1,493 citations

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1998 • 1,394 citations

Nod2, a Nod1/Apaf-1 Family Member That Is Restricted to Monocytes and Activates NF-κB

2001 • 1,331 citations

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid

2003 • 1,265 citations

RIN4 Interacts with Pseudomonas syringae Type III Effector Molecules and Is Required for RPM1-Mediated Resistance in Arabidopsis

2002 • 1,139 citations

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

1998 • 1,132 citations

Direct interaction of resistance gene and avirulence gene products confers rice blast resistance

2000 • 1,130 citations

NODs: intracellular proteins involved in inflammation and apoptosis

2003 • 1,041 citations

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

1996 • 1,027 citations

Clusters of Resistance Genes in Plants Evolve by Divergent Selection and a Birth-and-Death Process

1998 • 1,004 citations

Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria

2000 • 1,002 citations

CARD15/NOD2 Mutational Analysis and Genotype-Phenotype Correlation in 612 Patients with Inflammatory Bowel Disease

2002 • 979 citations

The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy

1995 • 976 citations

The Origins of Genomic Duplications in Arabidopsis

2000 • 973 citations

Arabidopsis RIN4 Is a Target of the Type III Virulence Effector AvrRpt2 and Modulates RPS2-Mediated Resistance

2003 • 950 citations

CARD15 mutations in Blau syndrome

2001 • 945 citations

Molecular Genetics of Plant Disease Resistance

1995 • 932 citations

Understanding the Functions of Plant Disease Resistance Proteins

2003 • 895 citations

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

2002 • 873 citations

NOD2 is a negative regulator of Toll-like receptor 2–mediated T helper type 1 responses

2004 • 831 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 828 citations

Plant disease resistance genes encode members of an ancient and diverse protein family within the nucleotide-binding superfamily

1999 • 808 citations

Spectrum of clinical features in Muckle‐Wells syndrome and response to anakinra

2004 • 746 citations

Chronic Infantile Neurological Cutaneous and Articular Syndrome Is Caused by Mutations in CIAS1, a Gene Highly Expressed in Polymorphonuclear Cells and Chondrocytes

2002 • 732 citations

R<scp>ESISTANCE</scp>G<scp>ENE</scp>C<scp>OMPLEXES</scp>: Evolution and Utilization

2001 • 731 citations

NALPs: a novel protein family involved in inflammation

2003 • 727 citations

Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB

1999 • 725 citations

De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal‐onset multisystem inflammatory disease (NOMID): A new member of the expanding family of pyrin‐associated autoinflammatory diseases

2002 • 693 citations

Initiation of Plant Disease Resistance by Physical Interaction of AvrPto and Pto Kinase

1996 • 664 citations

CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

2003 • 632 citations

Recognition and Response in the Plant Immune System

2003 • 596 citations

CARD4/Nod1 mediates NF‐κB and JNK activation by invasive Shigella flexneri

2001 • 588 citations

The Use of Zebrafish to Understand Immunity

2004 • 582 citations

The Genetics of Inflammatory Bowel Disease

2007 • 572 citations

Tomato Prf Is a Member of the Leucine-Rich Repeat Class of Plant Disease Resistance Genes and Lies Embedded within the Pto Kinase Gene Cluster

1996 • 558 citations

Genetic Control of MHC Class II Expression

2002 • 555 citations

The PYRIN-CARD Protein ASC Is an Activating Adaptor for Caspase-1

2002 • 543 citations

Cleavage of Arabidopsis PBS1 by a Bacterial Type III Effector

2003 • 542 citations

Human Nod1 Confers Responsiveness to Bacterial Lipopolysaccharides

2001 • 534 citations

Molecular Basis of Gene-for-Gene Specificity in Bacterial Speck Disease of Tomato

1996 • 531 citations

Crohn’s disease and the NOD2 gene: a role for paneth cells

2003 • 528 citations

The Bare Lymphocyte Syndrome and the Regulation of MHC Expression

2001 • 516 citations

Extensive Duplication and Reshuffling in the Arabidopsis Genome

2000 • 513 citations

Lack of common NOD2 variants in Japanese patients with Crohn's disease

2002 • 485 citations

Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU

2003 • 464 citations

Genome-wide identification of NBS genes in japonica rice reveals significant expansion of divergent non-TIR NBS-LRR genes

2004 • 459 citations

Induction of Nod2 in Myelomonocytic and Intestinal Epithelial Cells via Nuclear Factor-κB Activation

2002 • 442 citations

Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis

2003 • 421 citations

Segmental duplications and the evolution of the primate genome

2002 • 415 citations

Target-Selected Inactivation of the Zebrafish rag1 Gene

2002 • 397 citations

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

2002 • 395 citations

The genetics of inflammatory bowel disease

2003 • 363 citations

Human CARD4 Protein Is a Novel CED-4/Apaf-1 Cell Death Family Member That Activates NF-κB

1999 • 363 citations

PYPAF7, a Novel PYRIN-containing Apaf1-like Protein That Regulates Activation of NF-κB and Caspase-1-dependent Cytokine Processing

2002 • 362 citations

Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

2004 • 358 citations

Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

1996 • 356 citations

Common and Contrasting Themes of Plant and Animal Diseases

2001 • 352 citations

Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis

2002 • 350 citations

CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex

2000 • 338 citations

Apaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes

2000 • 321 citations

Apoptotic Molecular Machinery: Vastly Increased Complexity in Vertebrates Revealed by Genome Comparisons

2001 • 321 citations

Cutting Edge: CATERPILLER: A Large Family of Mammalian Genes Containing CARD, Pyrin, Nucleotide-Binding, and Leucine-Rich Repeat Domains

2002 • 311 citations

Gene–environment interaction modulated by allelic heterogeneity in inflammatory diseases

2003 • 307 citations

Toll-Like Receptors and Their Ligands

2002 • 303 citations

Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease

2002 • 297 citations

Interaction between Pyrin and the Apoptotic Speck Protein (ASC) Modulates ASC-induced Apoptosis

2001 • 284 citations

Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila

2002 • 280 citations

CARD15 Genetic Variation in a Quebec Population: Prevalence, Genotype-Phenotype Relationship, and Haplotype Structure

2002 • 279 citations

PYPAF1, a PYRIN-containing Apaf1-like Protein That Assembles with ASC and Regulates Activation of NF-κB

2002 • 267 citations

Naip5 Affects Host Susceptibility to the Intracellular Pathogen Legionella pneumophila

2003 • 261 citations

Role of Nod2 in the Response of Macrophages to Toll-Like Receptor Agonists

2003 • 260 citations

Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus

1997 • 254 citations

Cryopyrin-induced Interleukin 1β Secretion in Monocytic Cells

2004 • 233 citations

Apoptosis-Associated Speck-Like Protein Containing a Caspase Recruitment Domain Is a Regulator of Procaspase-1 Activation

2003 • 229 citations

IAP Suppression of Apoptosis Involves Distinct Mechanisms: the TAK1/JNK1 Signaling Cascade and Caspase Inhibition

2002 • 222 citations

Site α Is Crucial for Two Routes of IFNγ-Induced MHC Class I Transactivation: The ISRE-Mediated Route and a Novel Pathway Involving CIITA

1997 • 217 citations

Induction of MHC Class I Expression by the MHC Class II Transactivator CIITA

1997 • 209 citations

Transcriptional Scaffold: CIITA Interacts with NF-Y, RFX, and CREB To Cause Stereospecific Regulation of the Class II Major Histocompatibility Complex Promoter

2000 • 196 citations

Cutting Edge: CIAS1/Cryopyrin/PYPAF1/NALP3/ CATERPILLER 1.1 Is an Inducible Inflammatory Mediator with NF-κB Suppressive Properties

2003 • 195 citations

A Novel Enhancer of the Apaf1 Apoptosome Involved in Cytochrome c-dependent Caspase Activation and Apoptosis

2001 • 183 citations

The PYRIN domain: a novel motif found in apoptosis and inflammation proteins

2000 • 180 citations

Activation of class II MHC genes requires both the X ☐ region and the class II transactivator (CIITA)

1995 • 180 citations

The Neuronal Apoptosis Inhibitory Protein Is a Direct Inhibitor of Caspases 3 and 7

2002 • 173 citations

The PAAD/PYRIN-Family Protein ASC Is a Dual Regulator of a Conserved Step in Nuclear Factor κB Activation Pathways

2002 • 165 citations

Effector proteins of phytopathogenic bacteria: bifunctional signals in virulence and host recognition

2000 • 163 citations

Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses

2004 • 162 citations

The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappaB and pro-caspase-1 regulation

2003 • 161 citations

Transcriptional regulation of the MHC class II antigen presentation pathway

2003 • 157 citations

Human MHC class II gene transcription directed by the car☐yl terminus of CIITA, one of the defective genes in type II MHC combined immune deficiency

1995 • 156 citations

Plant disease resistance genes encode members of an ancient and diverse protein family within the nucleotide-binding superfamily

1999 • 150 citations

Molecular Cloning and Characterization of DEFCAP-L and -S, Two Isoforms of a Novel Member of the Mammalian Ced-4 Family of Apoptosis Proteins

2001 • 149 citations

The Death-domain Fold of the ASC PYRIN Domain, Presenting a Basis for PYRIN/PYRIN Recognition

2003 • 141 citations

Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product

2003 • 140 citations

PAAD – a new protein domain associated with apoptosis, cancer and autoimmune diseases

2001 • 139 citations

CIITA-regulated plexin-A1 affects T-cell–dendritic cell interactions

2003 • 136 citations

A CASE OF COLD URTICARIA WITH AN UNUSUAL FAMILY HISTORY

1940 • 131 citations

PYNOD, a novel Apaf‐1/CED4‐like protein is an inhibitor of ASC and caspase‐1

2004 • 131 citations

NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways

2000 • 129 citations

Caspy, a Zebrafish Caspase, Activated by ASC Oligomerization Is Required for Pharyngeal Arch Development

2003 • 109 citations

CIITA Leucine-Rich Repeats Control Nuclear Localization, In Vivo Recruitment to the Major Histocompatibility Complex (MHC) Class II Enhanceosome, and MHC Class II Gene Transactivation

2000 • 108 citations

Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome)

1993 • 107 citations

Transcriptional Coactivator, CIITA, Is an Acetyltransferase that Bypasses a Promoter Requirement for TAFII250

2001 • 107 citations

aIr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression.

1986 • 106 citations

Nod1, a CARD protein, enhances pro-interleukin-1β processing through the interaction with pro-caspase-1

2002 • 101 citations

How is the intracellular fate of the Legionella pneumophila phagosome determined?

1998 • 101 citations

GTP Binding by Class II Transactivator: Role in Nuclear Import

1999 • 100 citations

The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury

2000 • 98 citations

Importance of acidic, proline/serine/threonine-rich, and GTPbinding regions in the major histocompatibility complex class II transactivator: Generation of transdominant-negative mutants

1997 • 98 citations

Evidence that Dot-dependent and -independent factors isolate the Legionella pneumophila phagosome from the endocytic network in mouse macrophages

2001 • 96 citations

Two Distinct Domains within CIITA Mediate Self-Association: Involvement of the GTP-Binding and Leucine-Rich Repeat Domains

2001 • 93 citations

NOD2 3020insC frameshift mutation is not associated with inflammatory bowel disease in Chinese patients of Han nationality

2004 • 88 citations

A Defect in the Nuclear Translocation of CIITA Causes a Form of Type II Bare Lymphocyte Syndrome

1999 • 86 citations

Dendritic Cell-specific MHC Class II Transactivator Contains a Caspase Recruitment Domain That Confers Potent Transactivation Activity

2001 • 76 citations

Familial Cold Urticaria

1969 • 73 citations

CIITA stimulation of transcription factor binding to major histocompatibility complex class II and associated promotersin vivo

1998 • 72 citations

The Neuronal Apoptosis Inhibitory Protein (Naip) Is Expressed in Macrophages and Is Modulated After Phagocytosis and During Intracellular Infection withLegionella pneumophila

2000 • 67 citations

Reduced IL-4-, lipopolysaccharide-, and IFN-gamma-induced MHC class II expression in mice lacking class II transactivator due to targeted deletion of the GTP-binding domain.

1999 • 67 citations

The neuronal apoptosis inhibitory protein suppresses neuronal differentiation and apoptosis in PC12 cells

2000 • 64 citations

High-resolution Genetic and Physical Map of theLgn1Interval in C57BL/6J ImplicatesNaip2orNaip5inLegionella pneumophilaPathogenesis

2000 • 61 citations

Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location

2001 • 55 citations

Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes

2001 • 54 citations

Reduced IL-4-, Lipopolysaccharide-, and IFN-γ-Induced MHC Class II Expression in Mice Lacking Class II Transactivator Due to Targeted Deletion of the GTP-Binding Domain

1999 • 54 citations

Self-Association of CIITA and Its Transactivation Potential

2001 • 52 citations

When the Lymphocyte Loses Its Clothes

2003 • 52 citations

Spinal muscular atrophy

2004 • 52 citations

Two novel mutations in the MHC class II transactivator CIITA in a second patient from MHC class II deficiency complementation group A

1997 • 51 citations

Birth of 'human-specific' genes during primate evolution.

2003 • 51 citations

Genetic variation and activity of mouse Nod2, a susceptibility gene for Crohn’s disease☆☆Sequence data from this article have been deposited with the GenBank Data Library under Accession Nos. AY160220, AY160221, and AY160229–AY160678.

2003 • 49 citations

Mutation in the Class II trans-Activator Leading to a Mild Immunodeficiency

2001 • 45 citations

Self-association of Class II Transactivator Correlates with Its Intracellular Localization and Transactivation

2001 • 42 citations

The GTP-Binding Domain of Class II Transactivator Regulates Its Nuclear Export

2003 • 41 citations

Blau syndrome: A new kindred

2003 • 37 citations

Absence of MHC class II gene expression in a patient with a single amino acid substitution in the class II transactivator protein CIITA

1999 • 36 citations

Three novel mutations of the CIITA gene in MHC class II-deficient patients with a severe immunodeficiency

2002 • 36 citations

Analysis of Gene Expression During Maturation of Immature Dendritic Cells Derived from Peripheral Blood Monocytes

2002 • 33 citations

Characterization of the expressed CIITA allele in the class II MHC transcriptional mutant RJ2.2.5

1995 • 30 citations

NOD2/CARD15 and the Paneth cell: another piece in the genetic jigsaw of inflammatory bowel disease

2003 • 29 citations

Importance of class II transactivator leucine-rich repeats for dominant-negative function and nucleo-cytoplasmic transport

2003 • 28 citations

Leucine-rich repeats of the class II transactivator control its rate of nuclear accumulation

2002 • 28 citations

Defective MHC class II expression in an MHC class II deficiency patient is caused by a novel deletion of a splice donor site in the MHC class II transactivator gene

2000 • 24 citations

Induction of PYPAF1 during In Vitro Maturation of Mouse Mast Cells

2003 • 16 citations

Familial cold urticaria. A generalized reaction involving leukocytosis

1969 • 14 citations

NF-κB blockade exacerbates experimental colitis in transgenic mice expressing an intestinal epithelial cell (IEC) specific IκB super-repressor

2001 • 6 citations

Flice-inhibitory protein (FLIP) inhibits NF-KB signaling and is associated with an increased susceptibility to Fas-mediated apoptosis in differentiated HT-29 cells

2001 • 1 citations

PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1

2004 • 1 citations