Identification of Nucleolin as an AU-rich Element Binding Protein Involved in bcl-2 mRNA Stabilization

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Taxol stabilizes microtubules in mouse fibroblast cells.

1980 • 1,942 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin

1998 • 1,139 citations

Major nucleolar proteins shuttle between nucleus and cytoplasm

1989 • 1,113 citations

AU Binding Proteins Recruit the Exosome to Degrade ARE-Containing mRNAs

2001 • 859 citations

Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the invivo stability of ARE-containing mRNAs

1998 • 852 citations

RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein

1998 • 738 citations

Structure and functions of nucleolin

1999 • 728 citations

Evidence that Tristetraprolin Binds to AU-Rich Elements and Promotes the Deadenylation and Destabilization of Tumor Necrosis Factor Alpha mRNA

1999 • 725 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS

1996 • 653 citations

The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

1989 • 601 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1.

1993 • 533 citations

Molecular dissection of nucleolin's role in growth and cell proliferation: new insights

1999 • 483 citations

Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing G0----G1 transition.

1987 • 422 citations

Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation

2000 • 374 citations

The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements

2002 • 369 citations

Nucleolin functions in the first step of ribosomal RNA processing

1998 • 318 citations

The deadenylating nuclease (DAN) is involved in poly(A) tail removal during the meiotic maturation of Xenopus oocytes

1998 • 241 citations

Molecular basis of sequence-specific recognition of pre-ribosomal RNA by nucleolin

2000 • 207 citations

At the heart of the nucleolus

1987 • 197 citations

Cap-dependent deadenylation of mRNA

2000 • 184 citations

Isolation of an FMRP-Associated Messenger Ribonucleoprotein Particle and Identification of Nucleolin and the Fragile X-Related Proteins as Components of the Complex

1999 • 179 citations

A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements

2001 • 165 citations

The quantity of nucleolar proteins nucleolin and protein B23 is related to cell doubling time in human cancer cells.

1995 • 161 citations

HuA and Tristetraprolin Are Induced following T Cell Activation and Display Distinct but Overlapping RNA Binding Specificities

2001 • 138 citations

Okadaic acid mimics multiple changes in early protein phosphorylation and gene expression induced by tumor necrosis factor or interleukin-1.

1992 • 138 citations

Identification of nucleolin and nucleophosmin as genotoxic stress-responsive RNA-binding proteins

2002 • 129 citations

Bcl-2 Family Proteins: Strategies for Overcoming Chemoresistance in Cancer

1997 • 127 citations

RNA binding fragments from nucleolin contain the ribonucleoprotein consensus sequence.

1987 • 127 citations

Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1

1997 • 127 citations

Nucleolin Is a Protein Kinase C-ζ Substrate

1997 • 120 citations

A conserved AU‐rich element in the 3’ untranslated region ofbcl‐2 mRNA is endowed with a destabilizing function that is involved inbcl‐2 down‐regulation during apoptosis

2000 • 110 citations

New Approaches to Lymphoma Diagnosis

2001 • 103 citations

AUF1 Is a bcl-2 A + U-rich Element-binding Protein Involved in bcl-2 mRNA Destabilization during Apoptosis

2002 • 99 citations

Thermodynamics of Folding a Pseudoknotted mRNA Fragment

1994 • 99 citations

Apoptosis in Leukemia Cells Is Accompanied by Alterations in the Levels and Localization of Nucleolin

2003 • 95 citations

Amyloid precursor protein mRNA stability is controlled by a 29-base element in the 3'-untranslated region.

1994 • 94 citations

Posttranscriptional Control of Renin Synthesis

2003 • 90 citations

Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells

1999 • 73 citations

Anin VitroSystem Using HeLa Cytoplasmic Extracts That Reproduces Regulated mRNA Stability

1999 • 62 citations

Up-regulation of Nucleolin mRNA and Protein in Peripheral Blood Mononuclear Cells by Extracellular-regulated Kinase

2001 • 62 citations

Okadaic acid‐induced apoptosis of HL60 leukemia cells is preceded by destabilization of bcl‐2 mRNA and downregulation of bcl‐2 protein

1998 • 50 citations

G₁Phase-Dependent Expression of Bcl-2 mRNA and Protein Correlates with Chemoresistance of Human Cancer Cells

2000 • 46 citations

Regulation of mRNA stability in the nervous system and beyond

2001 • 42 citations

Taxol- and okadaic acid-induced destabilization of bcl-2 mRNA is associated with decreased binding of proteins to a bcl-2 instability element

2003 • 35 citations

Analysis of the AU-Rich Elements in the 3‘-Untranslated Region of β₂-Adrenergic Receptor mRNA by Mutagenesis and Identification of the Homologous AU-Rich Region from Different Species

1999 • 25 citations

Interaction of Protein Phosphatase 1 Delta with Nucleolin in Human Osteoblastic Cells

2002 • 22 citations

Apoptosis Is Associated with Modifications of bcl-2 mRNA AU-Binding Proteins

2001 • 20 citations

Specific dephosphorylation by phosphatases 1 and 2A of a nuclear protein structurally and immunologically related to nucleolin

1989 • 12 citations